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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Targeting matrix remodeling in cardiac hypertrophy and heart failure
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Paediatric anaesthesia - New drug developments
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New aspects of perioperative fluid therapy
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Preterm labour: Novel treatments
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Premature ejaculation - Dopaminergic control of ejaculation
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Male erectile dysfunction: Chemical pharmacology of penile erection
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Nitric oxide-based therapy for erectile disorders
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Novel muscarinic antagonists to treat incontinence and/or overactive bladder
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Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes
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Selective thyroid hormone agonists: A strategy for treating metabolic syndrome
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Endoplasmic reticulum stress and the c-Jun N-terminal kinase pathway in insulin resistance
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Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance
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Is the P2Y1 receptor a better target for antithrombotic drugs?
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Medications for the treatment of cocaine addiction: Emerging candidates
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Targeting heme oxygenase-1 in the treatment of atherosclerosis
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Selective inhibition of NADPH-oxidase isoforms as a therapeutic strategy in hypertension
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Yeast as a screening tool
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Multiplexed high content screening assays create a systems cell biology approach to drug discovery
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Molecular imprinting: A new tool for drug innovation
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Shaping biodegradable polymers as nanostructures: Fabrication and applications
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Smart polymeric micelles for gene and drug delivery
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Soluble polymer conjugates for drug delivery
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Chitosan and the mucosal delivery of biotechnology drugs
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Imaging approaches for monitoring chemotherapy
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Antimetabolites: A new perspective
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Registration of [18F]FDG microPET and small-animal MRI
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Benzodiazepine effect of 125I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model
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Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation
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Regional distribution of serotonin transporter protein in postmortem human brain
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Production, processing and small animal PET imaging of titanium-45
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Fully automated one-pot synthesis of [18F]fluoromisonidazole
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A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2′-fluoro-2′-deoxyuridine
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FDG-PET in the detection of early pancreatic cancer in a BOP hamster model
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In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker
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Optimizing an online SPE-HPLC method for analysis of (R)-[11C]1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide [(R)-[11C]PK11195] and its metabolites in humans
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Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo
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Biological properties of 2′-[18F]fluoroflumazenil for central benzodiazepine receptor imaging
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Development and biological evaluation of 99mTc-BAT-tropane esters
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Akt and emerging models for tumor cell energetics
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PMA-enhanced neutrophil [18F]FDG uptake is independent of integrin occupancy but requires PI3K activity
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What is to be gained by imaging the same animal before and after treatment?
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Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth
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Mass effect of injected dose in small rodent imaging by SPECT and PET
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Are there lessons to be learned from drug development that will accelerate the use of molecular imaging probes in the clinic?
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Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds
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Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957
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Improved quality control of [18F]FDG by HPLC with UV detection
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Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies
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Distribution and pharmacokinetic analysis of angiostatin radioiodine labeled with high stability
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Greater adenosine A2A receptor densities in cardiac and skeletal muscle in endurance-trained men: a [11C]TMSX PET study
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P(RNCH2CH2)N: efficient catalysts for the cyanosilylation of aldehydes and ketones
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Pharmacokinetics of Fluconazole and Fosfluconazole after Intraperitoneal Administration to Peritoneal Dialysis Rats
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Genetic Polymorphisms of UGT1A6 in a Japanese Population
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Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
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Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver
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Evaluation of Phenytoin Dosage Regimens Based on Genotyping of CYP2C Subfamily in Routinely Treated Japanese Patients†
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Novel Structure of the CYP2D6 Gene that Confuses Genotyping for the CYP2D6*5 Allele
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Estimation of In Vivo Percutaneous Absorption of Emedastine from Bile Excretion Data Using a Deconvolution Method
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L'histoire de l'Académie
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Le médicament au service de l'humanité
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4-aza-2,3-didéhydropodophyllotoxines : nouveaux lignanes à activité antitumorale obtenus par une synthèse en une seule étape
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One-pot synthesis of triazole-linked glycoconjugates
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Enantioselective intramolecular amidation of sulfamate esters catalyzed by chiral manganese(III) Schiff-base complexes
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Evaluation of Dextromethorphan Metabolism Using Hepatocytes from CYP2D6 Poor and Extensive Metabolizers
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Efficient parallel resolution of an active ester of 2-phenylpropionic acid using quasi-enantiomeric Evans' oxazolidinones
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Different reaction routes found in acid-catalyzed glycosylation of endo- and exo-glycals: competition between Ferrier rearrangement and protonation
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Synthesis of fused tetrahydro-β-carbolinequinoxalinones in 1-n-butyl-2,3-dimethylimidazolium bis(trifluoromethylsulfonyl)imide ([bdmim][Tf2N]) and 1-n-butyl-2,3-dimethylimidazolium perfluorobutylsulfonate ([bdmim][PFBuSO3]) ionic liquids
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Synthesis of bivalent ligands of β-carboline-3-carboxylates via a palladium-catalyzed homocoupling process
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NMR structural elucidation of photochromic quinolone photoproducts
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Theoretical study on the mechanism of N-heterocyclic carbene catalyzed transesterification reactions
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Direct organocatalytic in situ generation of novel push-pull dienamines: application in tandem Claisen-Schmidt/iso-aromatization reactions
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Bifurcate, tandem ATRC reactions: towards 2-oxabicyclo[4.3.0]nonane core of eunicellins
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Synthesis and derivatisation of N,N′-trisubstituted 1,2-diamines derived from (1R,2R)-1,2-diaminocyclohexane
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Synthesis of N,N′-disubstituted cyclic 1,2-diamines derived from (1R,2R)-1,2-diaminocyclohexane
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First regiospecific, enantiospecific total synthesis of gardnerine and gardnutine
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A new approach to pharmacological effects on ciliary beat frequency in cell cultures-exemplary measurements under Pelargonium sidoides extract (EPs 7630)
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Ionic liquid accelerated intramolecular hetero-Diels-Alder reactions: a protocol for the synthesis of octahydroacridines
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Alkynylation of N-tosylimines with aryl acetylenes promoted by ZnBr2 and N,N-diisopropylethylamine in acetonitrile
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Catalytic olefin epoxidation with cyclopentadienyl-molybdenum complexes in room temperature ionic liquids
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Fumigant toxicity of the essential oils of some African plants against Anopheles gambiae sensu stricto
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Antibacterial activity of α-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics
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Fangchinoline inhibited the antinociceptive effect of morphine in mice
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Antidepressant action of St. John's Wort, Hypericum perforatum: a test of the circadian hypotheses
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Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice
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The effect of Juzen-taiho-to/TJ-48 on the expression of killer-cell immunoglobulin-like receptors (CD158a/b) on peripheral lymphocytes in vitro experiment
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Biological activities of Ginkgo extracts
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Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.
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Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip
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Graphical contents list
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Epigallocatechin gallate (EGCG) (TEAVIGO™) does not impair nonhaem-iron absorption in man
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Role of n-methyl Pyrrolidone in the Enhancement of Aqueous Phase Transdermal Transport
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The Correction Factors Do Help in Improving the Prediction of Human Clearance from Animal Data
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Esters of 6-aminohexanoic acid as skin permeation enhancers: The effect of branching in the alkanol moiety
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The Use of 13C Labeling to Enhance the Sensitivity of 13C Solid-State CPMAS NMR to Study Polymorphism in Low Dose Solid Formulations
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Tea Tree Oil Concentration in Follicular Casts After Topical Delivery: Determination by High-Performance Thin Layer Chromatography Using a Perfused Bovine Udder Model
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β‐Cyclodextrin Reduces Bioavailability of Orally Administered [3H]Benzo[a]pyrene in the Rat
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Surface characterization of salmeterol xinafoate powders by inverse gas chromatography at finite coverage
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Two Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2D6 Gene in Japanese Individuals
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Glucuronidation of 2-(4-Chlorophenyl)-5-(2-Furyl)-4-Oxazoleacetic Acid (TA-1801A) in Humans: Species Differences in Liver and Intestinal Microsomes
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Transcellular Transport of Creatinine in Renal Tubular Epithelial Cell Line LLC-PK1
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