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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Effect of fluoro substituents and central atom nature on chiral derivatives of bisdiphenylborates and isoelectronic structures
Fulltext Access 6 Pages 2005
Synthesis and biocatalytic resolution of a new atropisomeric thiobiphenyl: (2,2′,6,6′-tetramethoxybiphenyl-3,3′-diyl)dimethanethiol
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Graphical contents list
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Chemoenzymatic preparation of the enantiomers of β-tryptophan ethyl ester and the β-amino nitrile analogue
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Synthesis and olfactory evaluation of the enantiomerically enriched forms of 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols isomers, identified in Passiflora edulis
Fulltext Access 6 Pages 2005
Dirhodium catalyzed intramolecular enantioselective C-H insertion reaction of N-cumyl-N-(2-p-anisylethyl)diazoacetamide: synthesis of (−)-Rolipram
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Graphical contents list
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Enzyme-assisted synthesis of (S)-1,3-dihydroxy-3,7-dimethyl-6-octen-2-one, the male-produced aggregation pheromone of the Colorado potato beetle, and its (R)-enantiomer
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The first asymmetric catalytic halo aldol reaction of β-iodo allenoates with aldehydes by using chiral salen catalyst
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Advances in analysis and synthesis of myo-inositol-derivatives through resolution by crystallisation
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Graphical contents list
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An efficient access to both enantiomers of pipecolic acid
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Synthesis of enantiomerically pure glycidol via a fully enantioselective lipase-catalyzed resolution
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Stereoselective synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2-(4-fluorophenoxymethyl)-3,4-O-isopropylidene tetrahydrofuran from mannose diace
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Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis
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Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone
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Structure–affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: halogenation and D1 receptor selectivity
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Synthesis and DNA-binding affinities of monomodified berberines
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A novel and selective monoamine oxidase B substrate
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Studies on interaction of an intramolecular charge transfer fluorescence probe: 4′-Dimethylamino-2,5-dihydroxychalcone with DNA
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Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening
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Irreversibly inhibitory kinetics of 3,5-dihydroxyphenyl decanoate on mushroom (Agaricus bisporus) tyrosinase
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Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino
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Tridemethylisovelleral, a potent cytotoxic agent
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Graphical contents list
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Synthesis and atropisomeric stability of 2,2′-bis(ferrocenylhydroxymethyl)-1,1′-biphenyl
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Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity
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Synthesis of complex carbobicyclic compounds from sugar allyltins: functionalization of the allylic position in bicyclo[4.3.0]nonene derivatives
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Neo-glycoconjugates: stereoselective synthesis of α-glycosyl amides via Staudinger ligation reactions
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Evaluation of substituent effects on activity and enantioselectivity in the enzymatic reduction of aryl ketones
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Syntheses of chiral hybrid O,N-donor ligands for the investigation of lanthanide complex reactivities in direct aldol condensations
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Graphical contents list
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First synthesis of 5,6-branched galacto-hexasaccharide, the dimer of the trisaccharide repeating unit of the cell-wall galactans of Bifidobacterium catenulatum YIT 4016
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Palladium-catalyzed asymmetric hydrovinylation under mild conditions using monodentate chiral spiro phosphoramidite and phosphite ligands
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Synthesis, NMR conformational studies and host-guest behaviour of new (+)-tartaric acid derivatives
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Enzymatic resolution of N-protected-β3-amino methyl esters, using lipase B from Candida antarctica
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Polymer-supported chiral phosphinooxathiane ligands for palladium-catalyzed asymmetric allylations
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Enantiopure erythro- and threo-1-aryl-1-[2-pyrrolidyl]-methanols: synthesis from l-proline
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3-N,N-Dimethylamino-3-deoxy lincomycin: A structure-based hybrid between lincomycin and the desosamine unit of erythromycin
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S-Oxidation products of (+)-thiomicamine-derived oxazolines-promising substrates in the synthesis of alkyl methyl sulfoxides
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Graphical contents list
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Enzymatic synthesis of N-glycoprotein linkage region disaccharide mimetics using β-N-acetylhexosaminidases from Aspergillus oryzae and Vigna radiata
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Syntheses of sugar-related pyrrolidine derivatives by reductive amination reactions
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Transglycosylation of tagatose with maltotriose by Bacillus stearothermophilus maltogenic amylase (BSMA)
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Synthesis of mono- and bisglucuronylated carboranes
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Biocatalytic asymmetric reduction of 3-acetylisoxazoles
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Synthesis of diastereo- and enantiomerically pure anti-3-methyl-1,4-pentanediol via lipase catalysed acylation
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Metal promoted asymmetry in the 1,2-diboroethylarene synthesis: diboration versus dihydroboration
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New unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligands derived from H8-BINOL for highly efficient Rh-catalyzed enantioselective hydrogenation
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Asymmetric induction in the conjugate addition of thioacetic acid to methacrylamides with chiral auxiliaries
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Synthesis of the (1S,2S)- and (1R,2S)-stereoisomers of the respective E- and Z-isomers of ethyl 4-[(2-hydroxycyclohexyl)methyl]phenoxy-3-methyl-2-butenoate using yeast whole cell bioreduction of the parent ketones
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Tunable dendritic ligands of chiral 1,2-diamine and their application in asymmetric transfer hydrogenation
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Graphical contents list
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Enantioselective reduction of benzofuryl halomethyl ketones: asymmetric synthesis of (R)-bufuralol
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Amination/annulation of chlorobutenones with chiral amine compounds: synthesis of 1,2,4-trisubstituted pyrroles
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A new approach to (+)-anisomycin
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Graphical contents list
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(1S,2S)-1-Amino-2-hydroxy-1,2,3,4-tetrahydronaphthalene: a new chiral auxiliary for asymmetric Reformatsky reactions
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Cumulative author index
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The synthesis of oximes and nitroalkanes bearing a chiral auxiliary unit: convenient substrates for the preparation of enantiomerically pure nitrile oxides
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The first simple and efficient synthesis of the unusual dipeptide part of Phomopsin A
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Chemistry of sulfones: synthesis of a new chiral nucleophilic catalyst
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The high-pressure [4+2]cycloaddition of 1-methoxybuta-1,3-diene to the glycolaldehyde-derived heterodienophiles, catalyzed by chiral metallosalen complexes
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Synthesis of Rosavin and its analogues based on a Mizoroki-Heck type reaction
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Chemoenzymatic synthesis of calcilytic agent NPS-2143 employing a lipase-mediated resolution protocol
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Enantioselective microbial reduction of 6-oxo-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
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The dynamic kinetic resolution of 3-oxo-4-phenyl-β-lactam by recombinant E. coli overexpressing yeast reductase Ara1p
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Preparation of (R)- and (S)-6-hydroxybuspirone by enzymatic resolution or hydroxylation
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New ferrocenyl P,S and S,S ligands for asymmetric catalysis
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Graphical contents list
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Palladium/chiral phosphine–olefin complexes: X-ray crystallographic analysis and the use in catalytic asymmetric allylic alkylation
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5-Methyl-4H-1,3-dioxins, new chiral building blocks: transformation into (R)- and (S)-4-hydroxymethyl-4-methyl-1,3-dioxolanes via oxidation and rearrangement and determination of the absolute configuration
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Solid state properties of 1,2-epoxy-3-(2-methoxyphenyloxy)-propane-valuable intermediate in non-racemic drug synthesis
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Studies on the construction of abutasterone-type and 24-epi-abutasterone-type side chains employing asymmetric dihydroxylation of (E)-20(22),24-cholestadiene
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Enantioselective aza-Michael reactions catalyzed by samarium iodobinaphtholate
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Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase
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Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp.
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On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-Fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle
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Solution conformations of amphidinolide H
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New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity
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Xanthocillins as thrombopoietin mimetic small molecules
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3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method
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Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
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Cytotoxic diterpenoids from two lianas from the Suriname rainforest
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QSAR studies of paeonol analogues for inhibition of platelet aggregation
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Biocidal activity of some Mannich base cationic derivatives
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Interaction of wogonin with bovine serum albumin
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Inclusion complexes of azadirachtin with native and methylated cyclodextrins: solubilization and binding ability
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Classical and dynamic resolution of 1-amino-3-methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one
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Synthesis and antimycobacterial evaluation of certain fluoroquinolone derivatives
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N,N′-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA
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Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells
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‘Green’ methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid
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Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents
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Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters
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Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity
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Cumulative author index
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Heterogeneous catalysis of the asymmetric aldol reaction by solid-supported proline-terminated peptides
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Graphical contents list
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Cumulative author index
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