Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase Fulltext Access 7 Pages 2008
Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates Fulltext Access 7 Pages 2008
Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction Fulltext Access 7 Pages 2008
HP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence Fulltext Access 7 Pages 2008
Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3â²-termini Fulltext Access 7 Pages 2008
Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines Fulltext Access 7 Pages 2008
Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives Fulltext Access 7 Pages 2008
A concise approach to 1,11-didechloro-6-methyl-4′-O-demethyl rebeccamycin and its binding to human serum albumin: Fluorescence spectroscopy and molecular modeling method Fulltext Access 7 Pages 2008
Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: Enhanced inhibition by their combination Fulltext Access 7 Pages 2008
Structure–activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects Fulltext Access 7 Pages 2008
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors Fulltext Access 7 Pages 2008
Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine conjugates Fulltext Access 7 Pages 2008
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases Fulltext Access 7 Pages 2008
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines Fulltext Access 7 Pages 2008
A novel sesquiterpene lactone from Centaurea pullata: Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties Fulltext Access 7 Pages 2008
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones Fulltext Access 7 Pages 2008
Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme Fulltext Access 7 Pages 2008
Synthetic homoserine lactone-derived sulfonylureas as inhibitors of Vibrio fischeri quorum sensing regulator Fulltext Access 7 Pages 2008
Carbonic anhydrase activators: Activation of the human tumor-associated isozymes IX and XII with amino acids and amines Fulltext Access 7 Pages 2008
Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR Fulltext Access 7 Pages 2008
Search for α-helical propensity in the receptor-bound conformation of glucagon-like peptide-1 Fulltext Access 7 Pages 2008
Photobactericidal plastic films based on cellulose esterified by chloroacetate and a cationic porphyrin Fulltext Access 7 Pages 2008
Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53 Fulltext Access 7 Pages 2008
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN) Fulltext Access 7 Pages 2008
Synthesis and structure-activity relationships of N-(3-phenylpropyl)-Nâ²-benzylpiperazines: Potent ligands for Ï1 and Ï2 receptors Fulltext Access 7 Pages 2008
Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors Fulltext Access 7 Pages 2008
Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts Fulltext Access 7 Pages 2008
Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides Fulltext Access 7 Pages 2008
Trypanosoma cruzi: Activities of lapachol and α- and β-lapachone derivatives against epimastigote and trypomastigote forms Fulltext Access 7 Pages 2008
Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives Fulltext Access 7 Pages 2008
Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines Fulltext Access 7 Pages 2008
Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis Fulltext Access 7 Pages 2008
G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution Fulltext Access 7 Pages 2008
Efficient synthesis and biological evaluation of two modafinil analogues Fulltext Access 7 Pages 2008
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors Fulltext Access 7 Pages 2008
Synthesis and monoamine transporter binding properties of 2β-[3′-(substituted benzyl)isoxazol-5-yl]- and 2β-[3′-methyl-4′-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes Fulltext Access 7 Pages 2008
Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines Fulltext Access 7 Pages 2008
A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol Fulltext Access 7 Pages 2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: Synthesis, cyclooxygenase inhibition, and nitric oxide release studies Fulltext Access 7 Pages 2008
Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets Fulltext Access 7 Pages 2008
N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Fulltext Access 7 Pages 2008
Effects of lipid constituents on membrane-permeabilizing activity of amphidinols Fulltext Access 7 Pages 2008
Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502) Fulltext Access 7 Pages 2008
Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate Fulltext Access 7 Pages 2008
Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages Fulltext Access 7 Pages 2008
Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs Fulltext Access 7 Pages 2008
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins Fulltext Access 7 Pages 2008
Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative Fulltext Access 7 Pages 2008
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter Fulltext Access 7 Pages 2008
NO-donors. Part 171: Synthesis and antimicrobial activity of novel ketoconazole–NO-donor hybrid compounds Fulltext Access 7 Pages 2008
Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues Fulltext Access 7 Pages 2008
Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase Fulltext Access 7 Pages 2008
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors Fulltext Access 7 Pages 2008
Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring Fulltext Access 7 Pages 2008
Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolines Fulltext Access 7 Pages 2008
Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors Fulltext Access 7 Pages 2008
Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with β-cyclodextrin Fulltext Access 7 Pages 2008
Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis Fulltext Access 7 Pages 2008
Suppression of cytokine production in lipopolysaccharide-stimulated mouse macrophages by novel cationic glucosamine derivative involves down-regulation of NF-κB and MAPK expressions Fulltext Access 7 Pages 2008
Chemoenzymatic synthesis of N-linked neoglycoproteins through a chitinase-catalyzed transglycosylation Fulltext Access 7 Pages 2008
Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation Fulltext Access 7 Pages 2008
New 7,8-benzoflavanones as potent aromatase inhibitors: Synthesis and biological evaluation Fulltext Access 7 Pages 2008
A photoswitchable ITAM peptidomimetic: Synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis–trans isomerization on binding Fulltext Access 7 Pages 2008
1-(1-Arylethylidene)thiosemicarbazide derivatives: A new class of tyrosinase inhibitors Fulltext Access 7 Pages 2008
Synthesis of (nor)tropeine (di)esters and allosteric modulation of glycine receptor binding Fulltext Access 7 Pages 2008
Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans Fulltext Access 7 Pages 2008
Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora Fulltext Access 7 Pages 2008
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors Fulltext Access 7 Pages 2008
Spectroscopic studies on the formation and thermal stability of DNA triplexes with a benzoannulated δ-carboline-oligonucleotide conjugate Fulltext Access 7 Pages 2008
Design and synthesis of novel 2′,3′-dideoxy-4′-selenonucleosides as potential antiviral agents Fulltext Access 7 Pages 2008
Sulfadiazine/hydroxypropyl-β-cyclodextrin host–guest system: Characterization, phase-solubility and molecular modeling Fulltext Access 7 Pages 2008
Synthesis and biochemical application of 2â²-O-methyl-3â²-thioguanosine as a probe to explore group I intron catalysis Fulltext Access 7 Pages 2008
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells Fulltext Access 7 Pages 2008
Synthesis and in vitro PDT activity of miscellaneous porphyrins with amino acid and uracil Fulltext Access 7 Pages 2008
Synthesis and receptor binding properties of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropane derivatives Fulltext Access 7 Pages 2008
Cytotoxic constituents from Brazilian red propolis and their structure–activity relationship Fulltext Access 7 Pages 2008
Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors Fulltext Access 7 Pages 2008
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents Fulltext Access 7 Pages 2008
A highly efficient biomimetic aromatization of Hantzsch-1,4-dihydropyridines with t-butylhydroperoxide, catalysed by iron(III) phthalocyanine chloride Fulltext Access 7 Pages 2008
Synergistic effect of basic residues at positions 14–15 of nociceptin on binding affinity and receptor activation Fulltext Access 7 Pages 2008
Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2′-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method Fulltext Access 7 Pages 2008
Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria Fulltext Access 7 Pages 2008
Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks Fulltext Access 7 Pages 2008
Investigations toward the selection of fully-modified 4′-thioRNA aptamers: Optimization of in vitro transcription steps in the presence of 4′-thioNTPs Fulltext Access 7 Pages 2008
Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and γ-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites Fulltext Access 7 Pages 2008
Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities Fulltext Access 7 Pages 2008
Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage Fulltext Access 7 Pages 2008
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015 Fulltext Access 7 Pages 2008
Evaluation of novel Hyphodermin derivatives as Glycogen Phosphorylase a inhibitors Fulltext Access 7 Pages 2008
Synthesis and activity on rat aorta rings and rat pancreatic β-cells of ring-opened analogues of benzopyran-type potassium channel activators Fulltext Access 7 Pages 2008
Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum Fulltext Access 7 Pages 2008