Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress Fulltext Access 7 Pages 2008
Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: Mechanism and substrate specificity Fulltext Access 7 Pages 2008
NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01 Fulltext Access 7 Pages 2008
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH, ion-pairing and skin species Fulltext Access 7 Pages 2008
In vitro release of propofol and binding capacity with regard to plasma constituents Fulltext Access 7 Pages 2008
Prostaglandin E2-loaded microspheres as strategy to inhibit phagocytosis and modulate inflammatory mediators release Fulltext Access 7 Pages 2008
Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulin Fulltext Access 7 Pages 2008
In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer–5-fluorouracil conjugates Fulltext Access 7 Pages 2008
Comparative permeability and diffusion kinetics of cyclosporine A liposomes and propylene glycol solution from human lung tissue into human blood ex vivo Fulltext Access 7 Pages 2008
Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis Fulltext Access 7 Pages 2008
Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides Fulltext Access 7 Pages 2008
The mitochondrial cocktail: Rationale for combined nutraceutical therapy in mitochondrial cytopathies Fulltext Access 7 Pages 2008
Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine Fulltext Access 7 Pages 2008
Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning Fulltext Access 7 Pages 2008
Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasound Fulltext Access 7 Pages 2008
Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes Fulltext Access 7 Pages 2008
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands Fulltext Access 7 Pages 2008
A graftable LDV peptidomimetic: Design, synthesis and application to a blood filtration membrane Fulltext Access 7 Pages 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies Fulltext Access 7 Pages 2008
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems Fulltext Access 7 Pages 2008
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1′ modifications for the exploration of the S1′ subsite Fulltext Access 7 Pages 2008
Mixed PEG–PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: Improved drug solubilization and enhanced in vitro cytotoxicity Fulltext Access 7 Pages 2008
Direct plasmid DNA encapsulation within PLGA nanospheres by single oil-in-water emulsion method Fulltext Access 7 Pages 2008
Synthesis and characterization of cyclic acetal based degradable hydrogels Fulltext Access 7 Pages 2008
The role of solution calorimetry in investigating controlled-release processes from polymeric drug delivery systems Fulltext Access 7 Pages 2008
Evaluation of brain-targeting for the nasal delivery of ergoloid mesylate by the microdialysis method in rats Fulltext Access 7 Pages 2008
Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime Fulltext Access 7 Pages 2008
Approval of new biopharmaceuticals 1999–2006: Comparison of the US, EU and Japan situations Fulltext Access 7 Pages 2008
Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator Fulltext Access 7 Pages 2008
The consequences of granulate heterogeneity towards breakage and attrition upon fluid-bed drying Fulltext Access 7 Pages 2008
Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability Fulltext Access 7 Pages 2008
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activation Fulltext Access 7 Pages 2008
Developing a tool for the preparation of GMP audit of pharmaceutical contract manufacturer Fulltext Access 7 Pages 2008
Dissolution test for site-specific release isoniazid pellets in USP apparatus 3 (reciprocating cylinder): Optimization using response surface methodology Fulltext Access 7 Pages 2008
Improved stomach selectivity of gene expression following microinstillation of plasmid DNA onto the gastric serosal surface in mice Fulltext Access 7 Pages 2008
The pH-controlled dual-drug release from mesoporous bioactive glass/polypeptide graft copolymer nanomicelle composites Fulltext Access 7 Pages 2008
Characterization of ternary solid dispersions of Itraconazole in polyethylene glycol 6000/polyvidone-vinylacetate 64 blends Fulltext Access 7 Pages 2008
Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol Fulltext Access 7 Pages 2008
Dissolution rate enhancement of the novel antitumoral β-lapachone by solvent change precipitation of microparticles Fulltext Access 7 Pages 2008
Cationic lipid/DNA complexes induce TNF-α secretion in splenic macrophages Fulltext Access 7 Pages 2008
Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions – A case study with itraconazole Fulltext Access 7 Pages 2008
Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets Fulltext Access 7 Pages 2008
[11C]Cyclopropyl-FLB 457: A PET radioligand for low densities of dopamine D2 receptors Fulltext Access 7 Pages 2008
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors Fulltext Access 7 Pages 2008
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824 Fulltext Access 7 Pages 2008
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors Fulltext Access 7 Pages 2008
3D QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies of fullerene-based HIV-1 PR inhibitors Fulltext Access 7 Pages 2008
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation Fulltext Access 7 Pages 2008
Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker Fulltext Access 7 Pages 2008
Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate Fulltext Access 7 Pages 2008
Reaction of 2′-deoxycytidine with peroxynitrite in the presence of ammonium bromide Fulltext Access 7 Pages 2008
Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer’s dementia models Fulltext Access 7 Pages 2008
Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins Fulltext Access 7 Pages 2008
Cu(I)–Glutathione complex: A potential source of superoxide radicals generation Fulltext Access 7 Pages 2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: Synthesis, nitric oxide release studies and anti-inflammatory activities Fulltext Access 7 Pages 2008
Synthesis and structure–activity relationships of metal–ligand complexes that potently inhibit cell migration Fulltext Access 7 Pages 2008
Synthesis and antiviral activity of new dimeric inhibitors against HIV-1 Fulltext Access 7 Pages 2008
Synthesis and insecticidal evaluation of novel N′-tert-butyl-N′-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives Fulltext Access 7 Pages 2008
Synthesis and pharmacological activity of aminoindanone dimers and related compounds Fulltext Access 7 Pages 2008
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs) Fulltext Access 7 Pages 2008
Anthracene based base-discriminating fluorescent oligonucleotide probes for SNPs typing: Synthesis and photophysical properties Fulltext Access 7 Pages 2008
Pyrene-modified guanosine as fluorescent probe for DNA modulated by charge transfer Fulltext Access 7 Pages 2008
Stereocontrolled synthesis and biological activity of two diastereoisomers of the potent HIV-1 protease inhibitor saquinavir Fulltext Access 7 Pages 2008
Design, synthesis and structure–activity study of shorter hexa peptide analogues as HIV-1 protease inhibitors Fulltext Access 7 Pages 2008
Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides Fulltext Access 7 Pages 2008
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17 Fulltext Access 7 Pages 2008
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies Fulltext Access 7 Pages 2008
Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis Fulltext Access 7 Pages 2008
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3 Fulltext Access 7 Pages 2008
Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor Fulltext Access 7 Pages 2008
Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats Fulltext Access 7 Pages 2008
4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I Fulltext Access 7 Pages 2008
Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors Fulltext Access 7 Pages 2008
Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication Fulltext Access 7 Pages 2008
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists Fulltext Access 7 Pages 2008
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines Fulltext Access 7 Pages 2008
Design of (N)-methanocarba adenosine 5′-uronamides as species-independent A3 receptor-selective agonists Fulltext Access 7 Pages 2008
Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: A novel pro-drug approach to increase exposure Fulltext Access 7 Pages 2008
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping Fulltext Access 7 Pages 2008
Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis Fulltext Access 7 Pages 2008
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives Fulltext Access 7 Pages 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide–isozyme II adduct Fulltext Access 7 Pages 2008
A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives Fulltext Access 7 Pages 2008
Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: Synthesis, spectral, antimicrobial, and DNA interaction approach Fulltext Access 7 Pages 2008