Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives Fulltext Access 11 Pages 2008
Synthesis and cytotoxic activity of γ-aryl substituted α-alkylidene-γ-lactones and α-alkylidene-γ-lactams Fulltext Access 11 Pages 2008
Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids Fulltext Access 11 Pages 2008
Chemo-, regio-, and stereoselectivity of F-ring opening reactions in the cephalostatin series Fulltext Access 11 Pages 2008
Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? Fulltext Access 11 Pages 2008
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter Fulltext Access 11 Pages 2008
Eupalinin A isolated from Eupatorium chinense L. induces autophagocytosis in human leukemia HL60 cells Fulltext Access 11 Pages 2008
Characterization and crystal structure of Escherichia coli KDPGal aldolase Fulltext Access 11 Pages 2008
Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88 Fulltext Access 11 Pages 2008
DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest Fulltext Access 11 Pages 2008
Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers Fulltext Access 11 Pages 2008
Synthesis of 1-substituted 3-pyridinylmethylidenylindolin-2-ones and 1-substituted 3-quinolinylmethylidenylindolin-2-ones as the enhancers of ATRA-induced differentiation in HL-60 cells Fulltext Access 11 Pages 2008
Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones Fulltext Access 11 Pages 2008
Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells Fulltext Access 11 Pages 2008
Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds Fulltext Access 11 Pages 2008
Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives Fulltext Access 11 Pages 2008
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer Fulltext Access 11 Pages 2008
Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme Fulltext Access 11 Pages 2008
Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells Fulltext Access 11 Pages 2008
Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid Fulltext Access 11 Pages 2008
Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates Fulltext Access 11 Pages 2008
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation Fulltext Access 11 Pages 2008
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs Fulltext Access 11 Pages 2008
Characterization of antigens adsorbed to anionic PLG microparticles by XPS and TOFâSIMS Fulltext Access 11 Pages 2008
Evaluating medication-related services in a hospital setting using the disconfirmation of expectations model of satisfaction Fulltext Access 11 Pages 2008
The relationship of calcium intake and exercise to osteoporosis health beliefs in postmenopausal women Fulltext Access 11 Pages 2008
Factors affecting demand among older adults for medication therapy management services Fulltext Access 11 Pages 2008
Synthesis and Characterization of a New Mebendazole Salt: Mebendazole Hydrochloride Fulltext Access 11 Pages 2008
Design and Evaluation of a Dry Coated Drug Delivery System with Floating–Pulsatile Release Fulltext Access 11 Pages 2008
Solubility of Solid Solutes in HFA‐134a With a Correlation to Physico‐Chemical Properties Fulltext Access 11 Pages 2008
Polymeric and Low Molecular Mass Efflux Pump Inhibitors for Oral Drug Delivery Fulltext Access 11 Pages 2008
Development of Nonsurfactant Cyclodextrin Nanoparticles Loaded With Anticancer Drug Paclitaxel Fulltext Access 11 Pages 2008
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ethambutol Dihydrochloride** Fulltext Access 11 Pages 2008
Liposomal Coencapsulated Fludarabine and Mitoxantrone for Lymphoproliferative Disorder Treatment* Fulltext Access 11 Pages 2008
11-(Pyridinylphenyl)steroids—A new class of mixed-profile progesterone agonists/antagonists Fulltext Access 11 Pages 2008
A modified surgical procedure for microdialysis probe implantation in the lateral ventricle of a FVB mouse Fulltext Access 11 Pages 2008
Drug release characteristics of physically crossâlinked thermosensitive poly(Nâvinylcaprolactam) hydrogel particles Fulltext Access 11 Pages 2008
Behaviour of Polysorbate 20 During Dialysis, Concentration and Filtration Using Membrane Separation Techniques Fulltext Access 11 Pages 2008
PhysicoâChemical and Technological Properties of Sodium Naproxen Granules Prepared in a HighâShear MixerâGranulator Fulltext Access 11 Pages 2008
Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine Fulltext Access 11 Pages 2008
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm Fulltext Access 11 Pages 2008
Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents Fulltext Access 11 Pages 2008
Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation Fulltext Access 11 Pages 2008
Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors Fulltext Access 11 Pages 2008
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors Fulltext Access 11 Pages 2008
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy Fulltext Access 11 Pages 2008
Molecular modeling and dynamics studies of Shikimate Kinase from Bacillus anthracis Fulltext Access 11 Pages 2008
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues Fulltext Access 11 Pages 2008
Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents Fulltext Access 11 Pages 2008
Computer based design, synthesis and biological evaluation of novel indole derivatives as HCV NS3-4A serine protease inhibitors Fulltext Access 11 Pages 2008
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D3-26,23-lactones—weak agonists Fulltext Access 11 Pages 2008
Selective A3 adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system Fulltext Access 11 Pages 2008
Theoretical analysis of the electronic properties of the sex pheromone and its analogue derivatives in the female processionary moth Thaumetopoea pytiocampa Fulltext Access 11 Pages 2008
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure Fulltext Access 11 Pages 2008
Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors Fulltext Access 11 Pages 2008
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity Fulltext Access 11 Pages 2008
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2′-furyl)-1,2,4-triazolo[1,5-a]quinoxalines Fulltext Access 11 Pages 2008
Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin Fulltext Access 11 Pages 2008
Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes Fulltext Access 11 Pages 2008
Antiproliferative effects on human tumor cells and rat aortic smooth muscular cells of 2,3-heteroarylmaleimides and heterofused imides Fulltext Access 11 Pages 2008
Capillary electrophoresis as a metabolomic tool in antioxidant therapy studies Fulltext Access 11 Pages 2008
Investigation of the stability of aromatic hydrazones in plasma and related biological material Fulltext Access 11 Pages 2008
Leveraging elevated temperature and particle size reduction to extract API from various tablet formulations Fulltext Access 11 Pages 2008
Application of experimental design in optimization of solid phase extraction of mycophenolic acid and mycophenolic acid glucuronide from human urine and plasma and SPE-RP-HPLC method validation Fulltext Access 11 Pages 2008
The Basis Function Regression in pharmaceutical analysis: Theory and example of application Fulltext Access 11 Pages 2008
Chemiluminescence detection of opium poppy (Papaver somniferum) alkaloids Fulltext Access 11 Pages 2008
Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents Fulltext Access 11 Pages 2008
Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: Effects of the phenyl substituent and the linker orientation Fulltext Access 11 Pages 2008
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties Fulltext Access 11 Pages 2008
Design and synthesis of cyclic disulfide-bonded antibacterial peptides on the basis of the α helical domain of Tenecin 1, an insect defensin Fulltext Access 11 Pages 2008
Modeling and synthesis of novel tight-binding inhibitors of cytochrome P450 2C9 Fulltext Access 11 Pages 2008
γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity Fulltext Access 11 Pages 2008
2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: Synthesis and structure–activity relationship Fulltext Access 11 Pages 2008
Antioxidant and cytotoxic activities of canadine: Biological effects and structural aspects Fulltext Access 11 Pages 2008
Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent Fulltext Access 11 Pages 2008
Using an aryl phenanthroimidazole moiety as a conjugated flexible intercalator to improve the hybridization efficiency of a triplex-forming oligonucleotide Fulltext Access 11 Pages 2008
Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro Fulltext Access 11 Pages 2008
Synthesis of methyl 5-S-alkyl-5-thio-d-arabinofuranosides and evaluation of their antimycobacterial activity Fulltext Access 11 Pages 2008
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues Fulltext Access 11 Pages 2008
Control and analysis of alkyl and benzyl halides and other related reactive organohalides as potential genotoxic impurities in active pharmaceutical ingredients (APIs) Fulltext Access 11 Pages 2008
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives Fulltext Access 11 Pages 2008
Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes Fulltext Access 11 Pages 2008
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage Fulltext Access 11 Pages 2008
Computational structure-activity relationship analysis of non-peptide inducers of macrophage tumor necrosis factor-α production Fulltext Access 11 Pages 2008
Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure–activity relationship and mechanism of action Fulltext Access 11 Pages 2008
Synthesis and anti-inflammatory structure–activity relationships of thiazine–quinoline–quinones: Inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis Fulltext Access 11 Pages 2008
Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions Fulltext Access 11 Pages 2008
Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides Fulltext Access 11 Pages 2008
Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: Synthesis and magnetic properties of potential PARACEST MRI contrast agents Fulltext Access 11 Pages 2008
Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor Fulltext Access 11 Pages 2008