Quantification of arsenic compounds using derivatization, solvent extraction and liquid chromatography electrospray ionization tandem mass spectrometry Fulltext Access 11 Pages 2008
Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action Fulltext Access 11 Pages 2008
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents Fulltext Access 11 Pages 2008
Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors Fulltext Access 11 Pages 2008
A novel Syk family kinase inhibitor: Design, synthesis, and structure–activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives Fulltext Access 11 Pages 2008
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one Fulltext Access 11 Pages 2008
Design and synthesis of novel oxazole containing 1,3-Dioxane-2-carboxylic acid derivatives as PPAR α/γ dual agonists Fulltext Access 11 Pages 2008
Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase Inhibitors Fulltext Access 11 Pages 2008
RCAI-17, 22, 24–26, 29, 31, 34–36, 38–40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines Fulltext Access 11 Pages 2008
Design, synthesis and evaluation of d-galactose-β-cyclodextrin conjugates as drug-carrying molecules Fulltext Access 11 Pages 2008
Interactions of sodium and potassium ions with oligonucleotides carrying human telomeric sequence and pyrene moieties at both termini Fulltext Access 11 Pages 2008
Development of an affinity silica monolith containing human serum albumin for chiral separations Fulltext Access 11 Pages 2008
Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against Ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice Fulltext Access 11 Pages 2008
The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D Fulltext Access 11 Pages 2008
C-2-Aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors Fulltext Access 11 Pages 2008
Development of tissue-targeted metabonomics. Part 1. Analytical considerations Fulltext Access 11 Pages 2008
A quality by design approach to impurity method development for atomoxetine hydrochloride (LY139603) Fulltext Access 11 Pages 2008
LC–MS/MS method for the determination of nine antidepressants and some of their main metabolites in oral fluid and plasma: Study of correlation between venlafaxine concentrations in both matrices Fulltext Access 11 Pages 2008
Analysis of illegally manufactured formulations of tadalafil (Cialis®) by 1H NMR, 2D DOSY 1H NMR and Raman spectroscopy Fulltext Access 11 Pages 2008
Impurity profile study of lopinavir and validation of HPLC method for the determination of related substances in lopinavir drug substance Fulltext Access 11 Pages 2008
Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors Fulltext Access 11 Pages 2008
Synthesis and structure–activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists Fulltext Access 12 Pages 2008
Design, synthesis and biological evaluation of new tryptamine and tetrahydro-β-carboline-based selective inhibitors of CDK4 Fulltext Access 12 Pages 2008
N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase Fulltext Access 12 Pages 2008
Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation Fulltext Access 12 Pages 2008
Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2 Fulltext Access 12 Pages 2008
Discovery of potent CCR4 antagonists: Synthesis and structure–activity relationship study of 2,4-diaminoquinazolines Fulltext Access 12 Pages 2008
A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis Fulltext Access 12 Pages 2008
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: Identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent Fulltext Access 12 Pages 2008
Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids Fulltext Access 12 Pages 2008
Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans Fulltext Access 12 Pages 2008
Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation Fulltext Access 12 Pages 2008
Structure–activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors Fulltext Access 12 Pages 2008
Binding to human serum albumin of zidovudine (AZT) and novel AZT derivatives. Experimental and theoretical analyses Fulltext Access 12 Pages 2008
A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines Fulltext Access 12 Pages 2008
Structure-based virtual screening against SARS-3CLpro to identify novel non-peptidic hits Fulltext Access 12 Pages 2008
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators Fulltext Access 12 Pages 2008
A structural analysis of the differential cytotoxicity of chemicals in the NCI-60 cancer cell lines Fulltext Access 12 Pages 2008
Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity Fulltext Access 12 Pages 2008
Synthesis of 2′-O-modified adenosine building blocks and application for RNA interference Fulltext Access 12 Pages 2008
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives Fulltext Access 12 Pages 2008
New cyanine dyes as base surrogates in PNA: Forced intercalation probes (FIT-probes) for homogeneous SNP detection Fulltext Access 12 Pages 2008
Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors Fulltext Access 12 Pages 2008
2D Autocorrelation, CoMFA, and CoMSIA modeling of protein tyrosine kinases’ inhibition by substituted pyrido[2,3-d]pyrimidine derivatives Fulltext Access 12 Pages 2008
Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents Fulltext Access 12 Pages 2008
Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities Fulltext Access 12 Pages 2008
The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-β-carbolines Fulltext Access 12 Pages 2008
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles Fulltext Access 12 Pages 2008
Computational modeling study of functional microdomains in cannabinoid receptor type 1 Fulltext Access 12 Pages 2008
Structure–antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues Fulltext Access 12 Pages 2008
Rate enhancement of the oxidative folding of lysozyme by the use of aromatic thiol containing redox buffers Fulltext Access 12 Pages 2008
Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids Fulltext Access 12 Pages 2008
SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region) Fulltext Access 12 Pages 2008
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists Fulltext Access 12 Pages 2008
Quantitative structure–activity relationship studies on nitrofuranyl anti-tubercular agents Fulltext Access 12 Pages 2008
Design and synthesis of a metabolically stable and potent antitussive agent, a novel δ opioid receptor antagonist, TRK-851 Fulltext Access 12 Pages 2008
New QSPR study for the prediction of aqueous solubility of drug-like compounds Fulltext Access 12 Pages 2008
Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin–cholestane hybrid compounds Fulltext Access 12 Pages 2008
Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition Fulltext Access 12 Pages 2008
Biochemical and biological properties of 5-bromotubercidin: Differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis Fulltext Access 12 Pages 2008
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models Fulltext Access 12 Pages 2008
Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines Fulltext Access 12 Pages 2008
N-Phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: Role of carbonyl groups in the covalent binding to the colchicine-binding site Fulltext Access 12 Pages 2008
Structure–activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction Fulltext Access 12 Pages 2008
Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies Fulltext Access 12 Pages 2008
Estradiol and estrone C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Blocking of ER+ breast cancer cell proliferation induced by estrone Fulltext Access 12 Pages 2008
Virtual screening approaches for the identification of non-lipid autotaxin inhibitors Fulltext Access 12 Pages 2008
Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression Fulltext Access 12 Pages 2008
Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives Fulltext Access 12 Pages 2008
Structure–toxicity relationship of aminoglycosides: Correlation of 2′-amine basicity with acute toxicity in pseudo-disaccharide scaffolds Fulltext Access 12 Pages 2008
Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells Fulltext Access 12 Pages 2008
Synthesis, structure–activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B Fulltext Access 12 Pages 2008
The molecular interactions of buspirone analogues with the serotonin transporter Fulltext Access 12 Pages 2008
1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis, biological activity, metabolic stability, and solubility Fulltext Access 12 Pages 2008
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin Fulltext Access 12 Pages 2008
Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors Fulltext Access 12 Pages 2008
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs Fulltext Access 12 Pages 2008
Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs Fulltext Access 12 Pages 2008
Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure–activity requirements Fulltext Access 12 Pages 2008
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine Fulltext Access 12 Pages 2008
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents Fulltext Access 12 Pages 2008
CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors Fulltext Access 12 Pages 2008
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity Fulltext Access 12 Pages 2008
Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists Fulltext Access 12 Pages 2008
Design of antiangiogenic hypoxic cell radiosensitizers: 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety Fulltext Access 12 Pages 2008
Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds Fulltext Access 12 Pages 2008
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile Fulltext Access 12 Pages 2008
Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing l-Arg and l-Asp or l-Glu Fulltext Access 12 Pages 2008
Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues Fulltext Access 12 Pages 2008
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents Fulltext Access 12 Pages 2008