Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells Fulltext Access 9 Pages 2006
Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites Fulltext Access 9 Pages 2006
Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties Fulltext Access 9 Pages 2006
A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells Fulltext Access 9 Pages 2006
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi Fulltext Access 9 Pages 2006
Synthesis and structure–activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB1) receptor ligands for potential use in molecular imaging Fulltext Access 9 Pages 2006
Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles Fulltext Access 9 Pages 2006
The conjugates of uracil–cyclen Zn(II) complexes: Synthesis, characterization, and their interaction with plasmid DNA Fulltext Access 9 Pages 2006
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents Fulltext Access 9 Pages 2006
A novel QSAR model for predicting induction of apoptosis by 4-aryl-4H-chromenes Fulltext Access 9 Pages 2006
The synthesis of l-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells Fulltext Access 9 Pages 2006
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings Fulltext Access 9 Pages 2006
A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines Fulltext Access 9 Pages 2006
Molybdenocene-oligonucleotide binding study at physiological pH using NMR spectroscopy and cyclic voltammetry Fulltext Access 9 Pages 2006
Insecticidal lead identification by screening benzopyrano[4,3-c] pyrazol-3(2H)-ones library constructed from multiple-parallel synthesis under microwave irradiation Fulltext Access 9 Pages 2006
A cationic chalcogenoxanthylium photosensitizer effective in vitro in chemosensitive and multidrug-resistant cells Fulltext Access 9 Pages 2006
Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]-N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration Fulltext Access 9 Pages 2006
Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents Fulltext Access 9 Pages 2006
Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates Fulltext Access 9 Pages 2006
New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates Fulltext Access 9 Pages 2006
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles Fulltext Access 9 Pages 2006
Effect of 2,6-di-O-methyl-α-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells Fulltext Access 9 Pages 2006
Acrylic terpolymer microcapsules for colon-specific drug delivery: effect of molecular weight and solubility of microencapsulated drugs on their release behaviors Fulltext Access 9 Pages 2006
Optimization of cross-linked high amylose starch microspheres containing 5-fluorouracil Fulltext Access 9 Pages 2006
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport Fulltext Access 9 Pages 2006
Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line Fulltext Access 9 Pages 2006
Relationship between genotype and enzyme activity of glutathione S-transferases M1 and P1 in Chinese Fulltext Access 9 Pages 2006
Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine Fulltext Access 9 Pages 2006
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells Fulltext Access 9 Pages 2006
Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C Fulltext Access 9 Pages 2006
Physico-chemical lyophilization behavior of mannitol, human serum albumin formulations Fulltext Access 9 Pages 2006
Development of polysaccharide gel-coated pellets for oral administration: 2. Calcium alginate Fulltext Access 9 Pages 2006
Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids Fulltext Access 9 Pages 2006
Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: Evidence for multifactorial multidrug resistance Fulltext Access 9 Pages 2006
Designing novel pH-sensitive non-phospholipid vesicle: Characterization and cell interaction Fulltext Access 9 Pages 2006
Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent Fulltext Access 9 Pages 2006
New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-α and NO production by human immune cells Fulltext Access 9 Pages 2006
Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones Fulltext Access 9 Pages 2006
Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells Fulltext Access 9 Pages 2006
Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC Fulltext Access 9 Pages 2006
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore Fulltext Access 9 Pages 2006
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK Fulltext Access 9 Pages 2006
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1H)-dione Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents Fulltext Access 9 Pages 2006
Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles Fulltext Access 9 Pages 2006
Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives Fulltext Access 9 Pages 2006
Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitors Fulltext Access 9 Pages 2006
Novel curcumin analogs targeting TNF-induced NF-κB activation and proliferation in human leukemic KBM-5 cells Fulltext Access 9 Pages 2006
Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b Fulltext Access 9 Pages 2006
Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones Fulltext Access 9 Pages 2006
Sildenafil/cyclodextrin complexation: Stability constants, thermodynamics, and guest–host interactions probed by 1H NMR and molecular modeling studies Fulltext Access 9 Pages 2006
Raman spectroscopy for tablet coating thickness quantification and coating characterization in the presence of strong fluorescent interference Fulltext Access 9 Pages 2006
Polysorbate 80 UV/vis spectral and chromatographic characteristics – defining boundary conditions for use of the surfactant in dissolution analysis Fulltext Access 9 Pages 2006
Application of solid-phase microextraction combined with derivatization to the enantiomeric determination of amphetamines Fulltext Access 9 Pages 2006
Physico-chemical characterisation and intrinsic dissolution studies of a new hydrate form of diclofenac sodium: comparison with anhydrous form Fulltext Access 9 Pages 2006
Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection Fulltext Access 9 Pages 2006
Non-parametric linear regression of discrete Fourier transform convoluted densitometric peak responses Fulltext Access 9 Pages 2006
Isolation and structural elucidation of tiamulin metabolites formed in liver microsomes of pigs Fulltext Access 9 Pages 2006
Stability studies of vorinostat and its two metabolites in human plasma, serum and urine Fulltext Access 9 Pages 2006
Rapid quantification of gabapentin in human plasma by liquid chromatography/tandem mass spectrometry Fulltext Access 9 Pages 2006
Systematic comparison of different functionality columns for a classical pharmaceutical problem Fulltext Access 9 Pages 2006
A monolithic-phase based on-line extraction approach for determination of pharmaceutical components in human plasma by HPLC–MS/MS and a comparison with liquid–liquid extraction Fulltext Access 9 Pages 2006
Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry Fulltext Access 9 Pages 2006
Catechin derivatives in Jatropha macrantha stems: Characterisation and LC/ESI/MS/MS quali–quantitative analysis Fulltext Access 9 Pages 2006
Identification and characterization of potential impurities of amlodipine maleate Fulltext Access 9 Pages 2006
Synthesis, cellular uptake and animal toxicity of a tetra(carboranylphenyl)-tetrabenzoporphyrin Fulltext Access 9 Pages 2006
Synthesis of amino acid derived seven-membered lactams by RCM and their evaluation against HIV protease Fulltext Access 9 Pages 2006
Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors Fulltext Access 9 Pages 2006
Green route for the heterocyclization of 2-mercaptobenzimidazole into β-lactum segment derivatives containing –CONH– bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganisms Fulltext Access 9 Pages 2006
Probing the physicochemical and structural requirements for glycogen synthase kinase-3α inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides Fulltext Access 9 Pages 2006
Acetoxy drug: Protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates Fulltext Access 9 Pages 2006
Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents Fulltext Access 9 Pages 2006
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABAC receptors Fulltext Access 9 Pages 2006
Anticancer and superoxide scavenging activities of p-alkylaminophenols having various length alkyl chains Fulltext Access 9 Pages 2006
Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with Naringenin Schiff-base Fulltext Access 9 Pages 2006
Novel stir bar sorptive extraction methods for environmental and biomedical analysis Fulltext Access 9 Pages 2006
Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1) Fulltext Access 9 Pages 2006
Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents Fulltext Access 9 Pages 2006
A combined approach of docking and 3D QSAR study of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors Fulltext Access 9 Pages 2006
Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes Fulltext Access 9 Pages 2006
Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum Fulltext Access 9 Pages 2006
Synthesis and biodistribution of [11C]R107474, a new radiolabeled α2-adrenoceptor antagonist Fulltext Access 9 Pages 2006
Synthesis of enantiopure Δ2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human β-adrenergic receptor subtypes Fulltext Access 9 Pages 2006
Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE) Fulltext Access 9 Pages 2006
Synthesis of new piperazine–pyridazinone derivatives and their binding affinity toward α1-, α2-adrenergic and 5-HT1A serotoninergic receptors Fulltext Access 9 Pages 2006
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design Fulltext Access 9 Pages 2006