Crystallographic studies on two bioisosteric analogues, N-acetyl-β-d-glucopyranosylamine and N-trifluoroacetyl-β-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Fulltext Access 9 Pages 2006
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design Fulltext Access 9 Pages 2006
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity Fulltext Access 9 Pages 2006
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase Fulltext Access 9 Pages 2006
Comparative molecular field analysis and comparative molecular similarity indices analysis of boron-containing human thymidine kinase 1 substrates Fulltext Access 9 Pages 2006
Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity Fulltext Access 9 Pages 2006
Structure–activity relationship of natural and synthetic coumarins inhibiting the multidrug transporter P-glycoprotein Fulltext Access 9 Pages 2006
Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents Fulltext Access 9 Pages 2006
New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: Analogues of HEAT as ligands for the α1-adrenergic receptor subtypes Fulltext Access 9 Pages 2006
Crystallographic studies on N-azidoacetyl-β-d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-β-d-glucopyranosylamine Fulltext Access 9 Pages 2006
Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives Fulltext Access 9 Pages 2006
Reassessing the melatonin pharmacophore—Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue Fulltext Access 9 Pages 2006
Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases Fulltext Access 9 Pages 2006
Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A Fulltext Access 9 Pages 2006
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system Fulltext Access 9 Pages 2006
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2 Fulltext Access 9 Pages 2006
A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan Fulltext Access 9 Pages 2006
Nucleosides with self-complementary hydrogen-bonding motifs: Synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system Fulltext Access 9 Pages 2006
Triple helix stabilization by covalently linked DNA–bisbenzimidazole conjugate synthesized by maleimide–thiol coupling chemistry Fulltext Access 9 Pages 2006
Polymeric grape-seed procyanidins, but not monomeric catechins and oligomeric procyanidins, impair degranulation and membrane ruffling in RBL-2H3 cells Fulltext Access 9 Pages 2006
Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile Fulltext Access 9 Pages 2006
Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain Fulltext Access 9 Pages 2006
Development and optimization of a useful assay for determining Hsp90’s inherent ATPase activity Fulltext Access 9 Pages 2006
Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: Novel compounds against aspergillosis Fulltext Access 9 Pages 2006
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity Fulltext Access 9 Pages 2006
Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex Fulltext Access 9 Pages 2006
Synthesis, antitumor and anti-HIV activities of benzodithiazine-dioxides Fulltext Access 9 Pages 2006
Steric interactions and the activity of fentanyl analogs at the μ-opioid receptor Fulltext Access 9 Pages 2006
α-1-C-Octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease Fulltext Access 9 Pages 2006
In silico identification and biochemical characterization of novel inhibitors of NQO1 Fulltext Access 9 Pages 2006
Quantitative structure–activity analysis of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors Fulltext Access 9 Pages 2006
Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution Fulltext Access 9 Pages 2006
Three-dimensional quantitative structure–activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors Fulltext Access 9 Pages 2006
Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists Fulltext Access 9 Pages 2006
Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors Fulltext Access 9 Pages 2006
Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite Fulltext Access 9 Pages 2006
Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity Fulltext Access 9 Pages 2006
Preparative separation and identification of derivatized β-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery Fulltext Access 9 Pages 2006
Determination of metabolic stability of positron emission tomography tracers by LC–MS/MS: An example in WAY-100635 and two analogues Fulltext Access 9 Pages 2006
Effects of liquid chromatography mobile phases and buffer salts on phosphorus inductively coupled plasma atomic emission and mass spectrometries utilizing ultrasonic nebulization and membrane desolvation Fulltext Access 9 Pages 2006
Synthetic polymers as biomacromolecular models for studying ligand–protein interactions: A nuclear spin relaxation approach Fulltext Access 9 Pages 2006
Sensitive and specific liquid chromatographic–tandem mass spectrometric assay for atropine and its eleven metabolites in rat urine Fulltext Access 9 Pages 2006
Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods Fulltext Access 9 Pages 2006
Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae Fulltext Access 9 Pages 2006
A new approach to evaluate regression models during validation of bioanalytical assays Fulltext Access 9 Pages 2006
Simultaneous quantification of six major phenolic acids in the roots of Salvia miltiorrhiza and four related traditional Chinese medicinal preparations by HPLC–DAD method Fulltext Access 9 Pages 2006
Determination of steroid sex hormones in water and urine matrices by stir bar sorptive extraction and liquid chromatography with diode array detection Fulltext Access 9 Pages 2006
A quality evaluation strategy for multi-sourced active pharmaceutical ingredient (API) starting materials Fulltext Access 9 Pages 2006
Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity Fulltext Access 9 Pages 2006
Identification of phenolic compounds in rosemary honey using solid-phase extraction by capillary electrophoresis–electrospray ionization-mass spectrometry Fulltext Access 9 Pages 2006
A rapid and simple procedure for the determination of ephedrine alkaloids in dietary supplements by gas chromatography–mass spectrometry Fulltext Access 9 Pages 2006
Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development Fulltext Access 9 Pages 2006
Stability of warfarin solutions for drug–protein binding measurements: Spectroscopic and chromatographic studies Fulltext Access 9 Pages 2006
Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: Piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H1) Fulltext Access 10 Pages 2006
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs Fulltext Access 10 Pages 2006
Design, synthesis, and evaluation of a novel series of α-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) α/δ dual agonists for the treatment of metabolic syndrome Fulltext Access 10 Pages 2006
A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors Fulltext Access 10 Pages 2006
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives Fulltext Access 10 Pages 2006
Synthesis, characterization, and anti-bacterial efficacy of some novel cyclophane amide Fulltext Access 10 Pages 2006
Synthesis and receptor binding studies of halogenated N,N-dialkylel-(2-phenyl-1H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET Fulltext Access 10 Pages 2006
Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides Fulltext Access 10 Pages 2006
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416 Fulltext Access 10 Pages 2006
Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure–activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents Fulltext Access 10 Pages 2006
Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine Fulltext Access 10 Pages 2006
QSAR models for Daphnia toxicity of pesticides based on combinations of topological parameters of molecular structures Fulltext Access 10 Pages 2006
The use of LC/MS, GC/MS, and LC/NMR hyphenated techniques to identify a drug degradation product in pharmaceutical development Fulltext Access 10 Pages 2006
A rapid HPLC–ESI-MS/MS for qualitative and quantitative analysis of saponins in “XUESETONG” injection Fulltext Access 10 Pages 2006
Evaluation of volatile ion-pair reagents for the liquid chromatography–mass spectrometry analysis of polar compounds and its application to the determination of methadone in human plasma Fulltext Access 10 Pages 2006
Characterizing the conversion kinetics of carbamazepine polymorphs to the dihydrate in aqueous suspension using Raman spectroscopy Fulltext Access 10 Pages 2006
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography Fulltext Access 10 Pages 2006
Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems Fulltext Access 10 Pages 2006
Stationary phases in the screening of drug/impurity profiles and in their separation method development: Identification of columns with different and similar selectivities Fulltext Access 10 Pages 2006
Validation of a gas chromatography—Ion trap tandem mass spectrometry for simultaneous analyse of cocaine and its metabolites in saliva Fulltext Access 10 Pages 2006
A 96-well single-pot liquid-liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma Fulltext Access 10 Pages 2006
New cytotoxic furoquinones obtained from terpenyl-1,4-naphthoquinones and 1,4-anthracenediones Fulltext Access 10 Pages 2006
Fluorescein-based amino acids for solid phase synthesis of fluorogenic protease substrates Fulltext Access 10 Pages 2006
A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11 Fulltext Access 10 Pages 2006
Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells’ activity Fulltext Access 10 Pages 2006
Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors Fulltext Access 10 Pages 2006
Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3′,2′:4,5]thieno- and thieno[2′,3′:4,5]thieno [2,3-c]quinolones: Synthesis, photochemical synthesis, DNA binding, and antitumor evalu Fulltext Access 10 Pages 2006
Antioxidant activity of β-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species? Fulltext Access 10 Pages 2006
Synthesis of multisubstituted quinolines from Baylis–Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity Fulltext Access 10 Pages 2006
Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands Fulltext Access 10 Pages 2006
The development of 3D-QSAR study and recursive partitioning of heterocyclic quinone derivatives with antifungal activity Fulltext Access 10 Pages 2006
Synthesis of 26,27-bisnorcastasterone analogs and analysis of conformation–activity relationship for brassinolide-like activity Fulltext Access 10 Pages 2006
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands Fulltext Access 10 Pages 2006
Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum Fulltext Access 10 Pages 2006
DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the α-glucosidase inhibitory activity Fulltext Access 10 Pages 2006