Structure basis for the inhibitory mechanism of a novel DNase γ-specific inhibitor, DR396 Fulltext Access 10 Pages 2006
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry Fulltext Access 10 Pages 2006
Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans Fulltext Access 10 Pages 2006
Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells Fulltext Access 10 Pages 2006
Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists Fulltext Access 10 Pages 2006
Induction of apoptosis in HeLa cells by 3β-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis Fulltext Access 10 Pages 2006
Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction Fulltext Access 10 Pages 2006
Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid Fulltext Access 10 Pages 2006
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides Fulltext Access 10 Pages 2006
Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1α,25-dihydroxyvitamin D3 analogues Fulltext Access 10 Pages 2006
Synthesis, molecular modelling and enzymatic evaluation of (±)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors Fulltext Access 10 Pages 2006
Dicationic pyridium porphyrins appending different peripheral substituents: Synthesis and studies for their interactions with DNA Fulltext Access 10 Pages 2006
3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents Fulltext Access 10 Pages 2006
Tetrahydropyrrolo[3,2-c]azepin-4-ones as a new class of cytotoxic compounds Fulltext Access 10 Pages 2006
The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A3 adenosine receptor antagonist Fulltext Access 10 Pages 2006
Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists Fulltext Access 10 Pages 2006
Synthesis, reactions and structure–activity relationships of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones: Illudin analogs with in vitro cytotoxic activity Fulltext Access 10 Pages 2006
QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1 Fulltext Access 10 Pages 2006
The binding of 3′-N-piperidine-4-carboxyl-3′-deoxy-ara-uridine to ribonuclease A in the crystal Fulltext Access 10 Pages 2006
Synthesis, characterization, and DNA-binding properties of the Ln(III) complexes with 6-hydroxy chromone-3-carbaldehyde-(2′-hydroxy) benzoyl hydrazone Fulltext Access 10 Pages 2006
Short pseudopeptides containing turn scaffolds with high AT2 receptor affinity Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of carboacyclic nucleosides with (Z) and (E)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain Fulltext Access 10 Pages 2006
Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity Fulltext Access 10 Pages 2006
Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates Fulltext Access 10 Pages 2006
One-step preparation of polyelectrolyte-coated PLGA microparticles and their functionalization with model ligands Fulltext Access 10 Pages 2006
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system Fulltext Access 10 Pages 2006
Liver targeting of catalase by cationization for prevention of acute liver failure in mice Fulltext Access 10 Pages 2006
Functionalization of multilayered DNA-coatings with bone morphogenetic protein 2 Fulltext Access 10 Pages 2006
Application of gold nanoparticles to microencapsulation of thioridazine Fulltext Access 10 Pages 2006
Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting Fulltext Access 10 Pages 2006
Chitosan–PEG nanocapsules as new carriers for oral peptide delivery: Effect of chitosan pegylation degree Fulltext Access 10 Pages 2006
Poly(ethylene glycol)/poly(ε-caprolactone) diblock copolymeric nanoparticles for non-viral gene delivery: The role of charge group and molecular weight in particle formation, cytotoxicity and transfection Fulltext Access 10 Pages 2006
Long-term release of fluocinolone acetonide using biodegradable fumarate-based polymers Fulltext Access 10 Pages 2006
In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug Fulltext Access 10 Pages 2006
Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo Fulltext Access 10 Pages 2006
Rat, ovine and bovine Peyer's patches mounted in horizontal diffusion chambers display sampling function Fulltext Access 10 Pages 2006
Optimising the incorporation and release of a neurotrophic factor using conducting polypyrrole Fulltext Access 10 Pages 2006
Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new Polymer-Lipid Hybrid Nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer Fulltext Access 10 Pages 2006
Development and characterisation of chitosan nanoparticles for siRNA delivery Fulltext Access 10 Pages 2006
Stability of poly(d,l-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems Fulltext Access 10 Pages 2006
Submicron lipid emulsion as a drug delivery system for nalbuphine and its prodrugs Fulltext Access 10 Pages 2006
Erbium:YAG laser-mediated oligonucleotide and DNA delivery via the skin: An animal study Fulltext Access 10 Pages 2006
Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors Fulltext Access 10 Pages 2006
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents Fulltext Access 10 Pages 2006
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Fulltext Access 10 Pages 2006
Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents Fulltext Access 10 Pages 2006
Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin Fulltext Access 10 Pages 2006
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues Fulltext Access 10 Pages 2006
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases Fulltext Access 10 Pages 2006
Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis Fulltext Access 10 Pages 2006
High-mannose-type glycan modifications of dihydrofolate reductase using glycan–methotrexate conjugates Fulltext Access 10 Pages 2006
Total syntheses of three copper (II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological properties in EMT-6 tumor-bearing mice Fulltext Access 10 Pages 2006
Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom Fulltext Access 10 Pages 2006
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ2 receptor ligands Fulltext Access 10 Pages 2006
Synthesis of dopamine transporter selective 3-diarylmethoxymethyl-8-arylalkyl-8-azabicyclo[3.2.1]octane derivatives Fulltext Access 10 Pages 2006
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands Fulltext Access 10 Pages 2006
Synthesis and SAR studies of a novel series of T-type calcium channel blockers Fulltext Access 10 Pages 2006
Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12 Fulltext Access 10 Pages 2006
Transfer of NIR calibrations for pharmaceutical formulations between different instruments Fulltext Access 10 Pages 2006
Simple assessment of homogeneity in pharmaceutical mixing processes using a near-infrared reflectance probe and control charts Fulltext Access 10 Pages 2006
Validated HPLC–MS/MS method for simultaneous determination of simvastatin and simvastatin hydroxy acid in human plasma Fulltext Access 10 Pages 2006
Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats Fulltext Access 10 Pages 2006
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals Fulltext Access 10 Pages 2006
Development of an enzyme-linked immunosorbent assay for fentanyl and applications of fentanyl antibody-coated nanoparticles for sample preparation Fulltext Access 10 Pages 2006
Evaluation of an International Pharmacopoeia method for the analysis of indinavir sulfate by liquid chromatography Fulltext Access 10 Pages 2006
Rapid determination of granisetron in human plasma by liquid chromatography coupled to tandem mass spectrometry and its application to bioequivalence study Fulltext Access 10 Pages 2006
Screening suspected counterfeit Viagra® and imitations of Viagra® with near-infrared spectroscopy Fulltext Access 10 Pages 2006
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors Fulltext Access 10 Pages 2006
Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters Fulltext Access 10 Pages 2006
Synthesis of new bioactive venlafaxine analogs: Novel thiazolidin-4-ones as antimicrobials Fulltext Access 10 Pages 2006
Effect of cholesterol on DMPC phospholipid membranes and QSAR model construction in membrane-interaction QSAR study through molecular dynamics simulation Fulltext Access 10 Pages 2006
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions Fulltext Access 10 Pages 2006
N-Thiolated β-lactam antibacterials: Effects of the N-organothio substituent on anti-MRSA activity Fulltext Access 10 Pages 2006
Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase Fulltext Access 10 Pages 2006
[(S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors Fulltext Access 10 Pages 2006
Comparative structure–activity relationships of benztropine analogues at the dopamine transporter and histamine H1 receptors Fulltext Access 10 Pages 2006
Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure–activity relationship Fulltext Access 10 Pages 2006
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists Fulltext Access 10 Pages 2006
Recent trends in the determination of polyphenols by electromigration methods Fulltext Access 10 Pages 2006
N-Terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: A mass spectrometry technique for N-terminus identification Fulltext Access 10 Pages 2006
The lethal effect of bis-type azridinylnaphthoquinone derivative on oral cancer cells (OEC-M1) associated with anti-apoptotic protein bcl-2 Fulltext Access 10 Pages 2006
Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities Fulltext Access 10 Pages 2006
Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin Fulltext Access 10 Pages 2006
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones Fulltext Access 10 Pages 2006
Optimizing phenylethylphosphonamidates for the inhibition of prostate-specific membrane antigen Fulltext Access 10 Pages 2006
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis Fulltext Access 10 Pages 2006
Aponeocarzinostatin-A superior drug carrier exhibiting unusually high endurance against denaturants Fulltext Access 10 Pages 2006
Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC) Fulltext Access 10 Pages 2006