Improved stability and oral bioavailability of Ganneng dropping pills following transforming lignans of herpetospermum caudigerum into nanosuspensions Fulltext Access 11 Pages 2018
Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart Fulltext Access 11 Pages 2018
Effects of biflavonoids from Garcinia madruno on a triple transgenic mouse model of Alzheimer's disease Fulltext Access 11 Pages 2018
Cardiovascular and renal interactions between cyclosporine and NSAIDs: Underlying mechanisms and clinical relevance Fulltext Access 11 Pages 2018
Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis Fulltext Access 11 Pages 2018
Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis Fulltext Access 11 Pages 2018
Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness Fulltext Access 11 Pages 2018
Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways Fulltext Access 11 Pages 2018
Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways Fulltext Access 11 Pages 2018
Novel effect of methionine enkephalin against influenza A virus infection through inhibiting TLR7-MyD88-TRAF6-NF-κB p65 signaling pathway Fulltext Access 11 Pages 2018
Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways Fulltext Access 11 Pages 2018
Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia Fulltext Access 11 Pages 2018
Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis Fulltext Access 11 Pages 2018
Microalgae-derived oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ Fulltext Access 11 Pages 2018
Rapid screening and identification of sesquiterpene lactones in Kudiezi injection based on high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry Fulltext Access 11 Pages 2018
Inhibitory effect of aloe emodin mediated photodynamic therapy on human oral mucosa carcinoma in vitro and in vivo Fulltext Access 11 Pages 2018
The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis Fulltext Access 11 Pages 2018
Zinc/alogliptin combination attenuates testicular toxicity induced by doxorubicin in rats: Role of oxidative stress, apoptosis and TGF-β1/NF-κB signaling Fulltext Access 11 Pages 2018
Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats Fulltext Access 11 Pages 2018
Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion Fulltext Access 11 Pages 2018
MiR-29b aggravates lipopolysaccharide-induced endothelial cells inflammatory damage by regulation of NF-κB and JNK signaling pathways Fulltext Access 11 Pages 2018
Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1 Fulltext Access 11 Pages 2018
Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model Fulltext Access 11 Pages 2018
An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis Fulltext Access 11 Pages 2018
Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathways Fulltext Access 11 Pages 2018
Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF Fulltext Access 11 Pages 2018
Mitochondria protecting amino acids: Application against a wide range of mitochondria-linked complications Fulltext Access 11 Pages 2018
The utilisation of human dialyzable leukocyte extract (IMMODIN) as adjuvant in albendazole therapy on mouse model of larval cestode infection: Immunomodulatory and hepatoprotective effects Fulltext Access 11 Pages 2018
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway Fulltext Access 11 Pages 2018
Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction Fulltext Access 11 Pages 2018
Combination of Ginsenoside H dripping pills and cyclophosphamide improve paraneoplastic syndrome and inhibit postoperative recurrence via the reversion of Th1/Th2 shift Fulltext Access 11 Pages 2018
LEF-1 gene silencing inhibits pulmonary vascular remodeling and occurrence of pulmonary arterial hypertension through the β-catenin signaling pathway Fulltext Access 11 Pages 2018
Downregulation of EB virus miR-BART4 inhibits proliferation and aggressiveness while promoting radiosensitivity of nasopharyngeal carcinoma Fulltext Access 11 Pages 2018
Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus Fulltext Access 11 Pages 2018
Protective effects of Kangxian ruangan capsule against nonalcoholic fatty liver disease fibrosis in rats induced by MCD diet Fulltext Access 11 Pages 2018
FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway Fulltext Access 11 Pages 2018
Quercus dilatata Lindl. ex Royle ameliorates BPA induced hepatotoxicity in Sprague Dawley rats Fulltext Access 11 Pages 2018
Syringic acid (SA) â A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance Fulltext Access 11 Pages 2018
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug Fulltext Access 11 Pages 2018
Pravastatin alleviates interleukin 1β-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition Fulltext Access 11 Pages 2018
Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: Involvement of NF-κB pathway and NLRP3 inflammasome Fulltext Access 11 Pages 2018
The lack of PI3Kγ favors M1 macrophage polarization and does not prevent kidney diseases progression Fulltext Access 11 Pages 2018
Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway Fulltext Access 11 Pages 2018
Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+-ATPase inhibition Fulltext Access 11 Pages 2018
Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line Fulltext Access 11 Pages 2018
Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling Fulltext Access 11 Pages 2018
Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation Fulltext Access 11 Pages 2018
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis Fulltext Access 11 Pages 2018
Current mechanistic insights into the CCCP-induced cell survival response Fulltext Access 11 Pages 2018
Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223 Fulltext Access 11 Pages 2018
Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes Fulltext Access 11 Pages 2018
Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line Fulltext Access 11 Pages 2018
The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy Fulltext Access 11 Pages 2018
Central nervous system diseases and Scutellaria: a review of current mechanism studies Fulltext Access 11 Pages 2018
Phosphoethanolamine induces caspase-independent cell death by reducing the expression of C-RAF and inhibits tumor growth in human melanoma model Fulltext Access 11 Pages 2018
Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates non-alcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction Fulltext Access 11 Pages 2018
Inhibition of Nogo-B promotes cardiac hypertrophy via endoplasmic reticulum stress Fulltext Access 11 Pages 2018
RNA sequencing enables systematic identification of platelet transcriptomic alterations in NSCLC patients Fulltext Access 11 Pages 2018
Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers Fulltext Access 11 Pages 2018
Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis Fulltext Access 11 Pages 2018
Expression kinetics reveal the self-adaptive role of β cells during the progression of diabetes Fulltext Access 11 Pages 2018
Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors Fulltext Access 11 Pages 2018
Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist Fulltext Access 11 Pages 2018
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice Fulltext Access 11 Pages 2018
Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623 Fulltext Access 11 Pages 2018
Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models Fulltext Access 11 Pages 2018
Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A Fulltext Access 11 Pages 2018
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases Fulltext Access 11 Pages 2018
Intestinal absorption of S-nitrosothiols: Permeability and transport mechanisms Fulltext Access 11 Pages 2018
HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis Fulltext Access 11 Pages 2018
Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5 Fulltext Access 11 Pages 2018
Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats Fulltext Access 11 Pages 2018
Chlorogenic acid attenuates glucotoxicity in H9c2 cells via inhibition of glycation and PKC α upregulation and safeguarding innate antioxidant status Fulltext Access 11 Pages 2018
Prevention of articular cartilage degeneration in a rat model of monosodium iodoacetate induced osteoarthritis by oral treatment with Withaferin A Fulltext Access 11 Pages 2018
Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways Fulltext Access 11 Pages 2018
Centella asiatica ameliorates diabetes-induced stress in rat tissues via influences on antioxidants and inflammatory cytokines Fulltext Access 11 Pages 2018
Autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone Fulltext Access 11 Pages 2018
Evaluation of the anti-hypertensive effect of Tengfu Jiangya tablet by combination of UPLC-Q-exactive-MS-based metabolomics and iTRAQ-based proteomics technology Fulltext Access 11 Pages 2018
Mechanisms of the active components from Korean pine nut preventing and treating d-galactose-induced aging rats Fulltext Access 11 Pages 2018
TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies Fulltext Access 11 Pages 2018
Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways Fulltext Access 11 Pages 2018
Long non-coding RNAs: An essential emerging field in kidney pathogenesis Fulltext Access 11 Pages 2018
Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review Fulltext Access 11 Pages 2018
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses Fulltext Access 11 Pages 2018
miR-145 overexpression triggers alteration of the whole transcriptome and inhibits breast cancer development Fulltext Access 11 Pages 2018
Pharmacological values and therapeutic properties of black tea (Camellia sinensis): A comprehensive overview Fulltext Access 11 Pages 2018
Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells Fulltext Access 11 Pages 2018
Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro Fulltext Access 11 Pages 2018
Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri Fulltext Access 11 Pages 2018
MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells Fulltext Access 11 Pages 2018
C-phycocyanin to overcome the multidrug resistance phenotype in human erythroleukemias with or without interaction with ABC transporters Fulltext Access 11 Pages 2018
Exogenous SERP1 attenuates restenosis by restoring GLP-1 receptor activity in diabetic rats following vascular injury Fulltext Access 11 Pages 2018
Co-encapsulation of dual drug loaded in MLNPs: Implication on sustained drug release and effectively inducing apoptosis in oral carcinoma cells Fulltext Access 11 Pages 2018
Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling Fulltext Access 11 Pages 2018
Phytol shows anti-angiogenic activity and induces apoptosis in A549 cells by depolarizing the mitochondrial membrane potential Fulltext Access 11 Pages 2018