Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba Fulltext Access 11 Pages 2018
Crosstalk between mAChRM3 and β2AR, via acetylcholine PI3/PKC/PBEP1/Raf-1 MEK1/2/ERK1/2 pathway activation, in human bronchial epithelial cells after long-term cigarette smoke exposure Fulltext Access 11 Pages 2018
Icariin inhibits LPS-induced cell inflammatory response by promoting GRα nuclear translocation and upregulating GRα expression Fulltext Access 11 Pages 2018
Antidiabetic effects of SGLT2 inhibitor ipragliflozin in type 2 diabetic mice fed diets containing different carbohydrate contents Fulltext Access 11 Pages 2018
Aromadendrene oxide 2, induces apoptosis in skin epidermoid cancer cells through ROS mediated mitochondrial pathway Fulltext Access 11 Pages 2018
Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo Fulltext Access 11 Pages 2018
Combined treatment with Dendrobium candidum and black tea extract promotes osteoprotective activity in ovariectomized estrogen deficient rats and osteoclast formation Fulltext Access 11 Pages 2018
Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria Fulltext Access 11 Pages 2018
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis Fulltext Access 11 Pages 2018
Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD Fulltext Access 11 Pages 2018
Comparison of different microscopy approaches to quantification of inhibitory effect on thrombus formation under flow conditions by the example of adenosine receptor agonist HE-NECA Fulltext Access 11 Pages 2018
Clozapine reduces Toll-like receptor 4/NF-κB-mediated inflammatory responses through inhibition of calcium/calmodulin-dependent Akt activation in microglia Fulltext Access 11 Pages 2018
Dual mechanisms of anti-muscarinic and Ca++ antagonistic activities to validate the folkloric uses of Cyperus niveus Retz. as antispasmodic and antidiarrheal Fulltext Access 11 Pages 2018
Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities Fulltext Access 11 Pages 2018
Alisma canaliculatum ethanol extract suppresses inflammatory responses in LPS-stimulated macrophages, HCl/EtOH-induced gastritis, and DSS-triggered colitis by targeting Src/Syk and TAK1 activities Fulltext Access 11 Pages 2018
Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway Fulltext Access 11 Pages 2018
Dioscorea zingiberensis C. H. Wright: An overview on its traditional use, phytochemistry, pharmacology, clinical applications, quality control, and toxicity Fulltext Access 11 Pages 2018
Wound healing and anti-inflammatory activities induced by a Plantago australis hydroethanolic extract standardized in verbascoside Fulltext Access 11 Pages 2018
New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation Fulltext Access 11 Pages 2018
The risk of immune-related endocrine disorders associated with anti-PD-1 inhibitors therapy for solid tumors: A systematic review and meta-analysis Fulltext Access 11 Pages 2018
Topically applied azaphenothiazines inhibit experimental psoriasis in mice Fulltext Access 11 Pages 2018
Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity Fulltext Access 11 Pages 2018
Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity Fulltext Access 11 Pages 2018
The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model Fulltext Access 11 Pages 2018
Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2 Fulltext Access 11 Pages 2018
mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction Fulltext Access 11 Pages 2018
Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial, Fulltext Access 11 Pages 2018
Redox- and pH-Responsive Nanoparticles Release Piperlongumine in a Stimuli-Sensitive Manner to Inhibit Pulmonary Metastasis of Colorectal Carcinoma Cells Fulltext Access 11 Pages 2018
Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins Fulltext Access 11 Pages 2018
The effects of synthetic cannabinoids (SCs) on brain structure and function Fulltext Access 11 Pages 2018
Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress Fulltext Access 11 Pages 2018
Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway Fulltext Access 11 Pages 2018
Dysregulated microRNA expression profiles in cholangiocarcinoma cell-derived exosomes Fulltext Access 11 Pages 2018
Anxiolytic-like effect of pyridoxine in mice by elevated plus maze and light and dark box: Evidence for the involvement of GABAergic and NO-sGC-cGMP pathway Fulltext Access 11 Pages 2018
Therapeutic efficacy and safety of Kang-ai injection combined with platinum-based doublet chemotherapy in advanced NSCLC: A meta-analysis Fulltext Access 11 Pages 2018
Effective cancer immunotherapy based on combination of TLR agonists with stimulation of phagocytosis Fulltext Access 11 Pages 2018
Impact of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and lactation: a focus on short and long-term vascular effects Fulltext Access 11 Pages 2018
Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology Fulltext Access 11 Pages 2018
Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark extract Fulltext Access 11 Pages 2018
Lateral flow immunoassay and enzyme linked immunosorbent assay as effective immunomethods for the detection of synthetic cannabinoid JWH-200 based on the newly synthesized hapten Fulltext Access 11 Pages 2018
Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach Fulltext Access 11 Pages 2018
Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys Fulltext Access 11 Pages 2018
Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts Fulltext Access 11 Pages 2018
Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation Fulltext Access 11 Pages 2018
Short- and long-term gene expression profiles induced by inhaled TiO2 nanostructured aerosol in rat lung Fulltext Access 11 Pages 2018
The pharmacological treatment of chronic comorbidities in COPD: mind the gap! Fulltext Access 11 Pages 2018
Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio Fulltext Access 11 Pages 2018
Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids Fulltext Access 11 Pages 2018
Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy Fulltext Access 11 Pages 2018
1,25-Dihydroxyvitamin-D3 induces brain proteomic changes in cuprizone mice during remyelination involving calcium proteins Fulltext Access 11 Pages 2018
Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques Fulltext Access 11 Pages 2018
S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats Fulltext Access 11 Pages 2018
Botulinum toxin type A and gabapentin attenuate postoperative pain and NK1 receptor internalization in rats Fulltext Access 11 Pages 2018
Inhibition of VEGF-Flk-1 binding induced profound biochemical alteration in the hippocampus of a rat model of BBB breakdown by spider venom. A preliminary assessment using FT-IR spectroscopy Fulltext Access 11 Pages 2018
Mimicking the 3D biology of osteochondral tissue with microfluidic-based solutions: breakthroughs towards boosting drug testing and discovery Fulltext Access 11 Pages 2018
A three year study of metal levels in skin biopsies of whales in the Gulf of Mexico after the Deepwater Horizon oil crisis Fulltext Access 11 Pages 2018
Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod (Boreogadus saida) Fulltext Access 11 Pages 2018
131I-Evans blue: evaluation of necrosis targeting property and preliminary assessment of the mechanism in animal models Fulltext Access 11 Pages 2018
Striatal dopamine release and impaired reinforcement learning in adults with 22q11.2 deletion syndrome Fulltext Access 11 Pages 2018
Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice Fulltext Access 11 Pages 2018
Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves Fulltext Access 11 Pages 2018
Syzygium cumini leaf extract inhibits LDL oxidation, but does not protect the liproprotein from glycation Fulltext Access 11 Pages 2018
A review of cinnabar (HgS) and/or realgar (As4S4)-containing traditional medicines Fulltext Access 11 Pages 2018
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters Fulltext Access 11 Pages 2018
Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice Fulltext Access 11 Pages 2018
Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators Fulltext Access 11 Pages 2018
Best practice in research: Consensus Statement on Ethnopharmacological Field Studies - ConSEFS Fulltext Access 11 Pages 2018
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Fulltext Access 11 Pages 2018
The mechanisms of Ag85A DNA vaccine activates RNA sensors through new signal transduction Fulltext Access 11 Pages 2018
Immunomodulatory effects of Tinospora crispa extract and its major compounds on the immune functions of RAW 264.7 macrophages Fulltext Access 11 Pages 2018
Investigation of the interaction of allergens of Glycine max with IgE-antibody for designing of peptidomimetics based anti-allergen Fulltext Access 11 Pages 2018
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway Fulltext Access 11 Pages 2018
A synthetic diosgenin primary amine derivative attenuates LPS-stimulated inflammation via inhibition of NF-κB and JNK MAPK signaling in microglial BV2 cells Fulltext Access 11 Pages 2018
Comparison of six cell penetrating peptides with different properties for in vitro and in vivo delivery of HPV16 E7 antigen in therapeutic vaccines Fulltext Access 11 Pages 2018
Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors Fulltext Access 11 Pages 2018
Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry Fulltext Access 11 Pages 2018
Thiotagetin B and tagetannins A and B, new acetylenic thiophene and digalloyl glucose derivatives from Tagetes minuta and evaluation of their in vitro antioxidative and anti-inflammatory activity Fulltext Access 11 Pages 2018
β-1,3/1,4-Glucan Lichenan from Cetraria islandica (L.) ACH. induces cellular differentiation of human keratinocytes Fulltext Access 11 Pages 2018
Trans-crocin 4 is not hydrolyzed to crocetin following i.p. administration in mice, while it shows penetration through the blood brain barrier Fulltext Access 11 Pages 2018
Ancistroyafungines A-D, 5,8â²- and 5,1â²-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells Fulltext Access 11 Pages 2018
Cyclodextrin Multicomponent Complexation and Controlled Release Delivery Strategies to Optimize the Oral Bioavailability of Vinpocetine Fulltext Access 11 Pages 2018
Maternal stress and the MPOA: Activation of CRF receptor 1 impairs maternal behavior and triggers local oxytocin release in lactating rats Fulltext Access 11 Pages 2018
5-HT2A-mGlu2/3 receptor complex in rat spinal cord glutamatergic nerve endings: A 5-HT2A to mGlu2/3 signalling to amplify presynaptic mechanism of auto-control of glutamate exocytosis Fulltext Access 11 Pages 2018
Angiotensin II facilitates GABAergic neurotransmission at postsynaptic sites in rat amygdala neurons Fulltext Access 11 Pages 2018
Complexes of Felodipine Nanoparticles With Zein Prepared Using a Dual Shift Technique Fulltext Access 11 Pages 2018
Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification Fulltext Access 11 Pages 2018
Improved method for synthesis of low molecular weight protamine-siRNA conjugate Fulltext Access 11 Pages 2018
Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation Fulltext Access 11 Pages 2018
Genomic survey of bZIP transcription factor genes related to tanshinone biosynthesis in Salvia miltiorrhiza Fulltext Access 11 Pages 2018
Rhizospheric microbial communities are driven by Panax ginseng at different growth stages and biocontrol bacteria alleviates replanting mortality Fulltext Access 11 Pages 2018
Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step Förster resonance energy transfer imaging Fulltext Access 11 Pages 2018