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Pharmacology Research Articles

Antibiotic-induced dysbiosis effects on the murine gastrointestinal tract and their systemic repercussions
Fulltext Access 12 Pages 2018
Development-related aberrations in Kv1.1 α-subunit exert disruptive effects on bioelectrical activities of neurons in a mouse model of fragile X syndrome
Fulltext Access 12 Pages 2018
The role of human dopamine transporter in NeuroAIDS
Fulltext Access 12 Pages 2018
Prostaglandin E2 as a Regulator of Immunity to Pathogens
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Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Fulltext Access 12 Pages 2018
Possible use of Punica granatum (Pomegranate) in cancer therapy
Fulltext Access 12 Pages 2018
Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help
Fulltext Access 12 Pages 2018
The burgeoning role of cytochrome P450-mediated vitamin D metabolites against colorectal cancer
Fulltext Access 12 Pages 2018
Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?
Fulltext Access 12 Pages 2018
Parameter-specific analgesic effects of electroacupuncture mediated by degree of regulation TRPV1 and P2X3 in inflammatory pain in rats
Fulltext Access 12 Pages 2018
Hypoxia-inducible bidirectional shRNA expression vector delivery using PEI/chitosan-TBA copolymers for colorectal Cancer gene therapy
Fulltext Access 12 Pages 2018
Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats
Fulltext Access 12 Pages 2018
The role of β2 integrin associated heparin-binding protein release in ARDS
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Zebrafish models relevant to studying central opioid and endocannabinoid systems
Fulltext Access 12 Pages 2018
Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis
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CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress
Fulltext Access 12 Pages 2018
Endothelial colony forming cells from human umbilical cord blood improved severe erectile dysfunction in obese type II diabetic rats
Fulltext Access 12 Pages 2018
Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma
Fulltext Access 12 Pages 2018
Pharmacological evaluation of novel PKR inhibitor indirubin-3-hydrazone in-vitro in cardiac myocytes and in-vivo in wistar rats
Fulltext Access 12 Pages 2018
Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P
Fulltext Access 12 Pages 2018
Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application
Fulltext Access 12 Pages 2018
Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain
Fulltext Access 12 Pages 2018
Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway
Fulltext Access 12 Pages 2018
Rhizoma Amorphophalli inhibits TNBC cell proliferation, migration, invasion and metastasis through the PI3K/Akt/mTOR pathway
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Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages
Fulltext Access 12 Pages 2018
Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD
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Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801
Fulltext Access 12 Pages 2018
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation
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A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response
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Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS
Fulltext Access 12 Pages 2018
Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease
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Isoliquiritigenin protects against blood‑brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury
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Amphotericin B-Loaded Poly(lactic-co-glycolic acid) Nanofibers: An Alternative Therapy Scheme for Local Treatment of Vulvovaginal Candidiasis
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Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10
Fulltext Access 12 Pages 2018
The affinity of antipsychotic drugs to dopamine and serotonin 5-HT2 receptors determines their effects on prefrontal-striatal functional connectivity
Fulltext Access 12 Pages 2018
Visual and auditory emotion recognition problems as familial cross-disorder phenomenon in ASD and ADHD
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Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro
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HIV pre-exposure prophylaxis: Exploring the potential for expanding the role of pharmacists in public health
Fulltext Access 12 Pages 2018
Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice
Fulltext Access 12 Pages 2018
Influence of formulation of ZnO nanoblokes containing metallic ions dopants on their cytotoxicity and protective factors: An in vitro study on human skin cells exposed to UVA radiation
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Nevada desert dust with heavy metals suppresses IgM antibody production
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CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish
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Sex-dependent impact of Roundup on the rat gut microbiome
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Decanoic acid suppresses proliferation and invasiveness of human trophoblast cells by disrupting mitochondrial function
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Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish
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nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11β-HSD2
Fulltext Access 12 Pages 2018
The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects
Fulltext Access 12 Pages 2018
Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods
Fulltext Access 12 Pages 2018
Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis
Fulltext Access 12 Pages 2018
La lombalgie récurrente ou lombalgie chronique ?
Fulltext Access 12 Pages 2018
A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
Fulltext Access 12 Pages 2018
Plastome-wide comparison reveals new SNV resources for the authentication of Dendrobium huoshanense and its corresponding medicinal slice (Huoshan Fengdou)
Fulltext Access 12 Pages 2018
Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway
Fulltext Access 12 Pages 2018
Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo
Fulltext Access 12 Pages 2018
Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220
Fulltext Access 12 Pages 2018
Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy
Fulltext Access 12 Pages 2018
Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection
Fulltext Access 12 Pages 2018
Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats
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Biochemical and physiological effects of nickel in the euryhaline crab Neohelice granulata (Dana, 1851) acclimated to different salinities
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Behavior of detoxifying enzymes of Aedes aegypti exposed to girgensohnine alkaloid analog and Cymbopogon flexuosus essential oil
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Biochemical characterization of venom from Pseudoboa neuwiedii (Neuwied's false boa; Xenodontinae; Pseudoboini)
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Évaluation de la satisfaction des patients lombalgiques chroniques traités par la neurostimulation bénéficiant d'un programme d'éducation thérapeutique
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Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis
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Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor
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Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder
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Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid
Fulltext Access 12 Pages 2018
Adjunctive treatment with brexpiprazole and escitalopram reduces behavioral stress responses and increase hypothalamic NPY immunoreactivity in a rat model of PTSD-like symptoms
Fulltext Access 12 Pages 2018
Reduced insulin sensitivity may be related to less striatal glutamate: An 1H-MRS study in healthy non-obese humans
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DNA methylation of APBA3 and MCF2 in borderline personality disorder: Potential biomarkers for response to psychotherapy
Fulltext Access 12 Pages 2018
DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions
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Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice
Fulltext Access 12 Pages 2018
Toxicological effects of Nux Vomica in rats urine and serum by means of clinical chemistry, histopathology and 1H NMR-based metabonomics approach
Fulltext Access 12 Pages 2018
Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells
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Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait)
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Design of Hollow Hyaluronic Acid Cylinders for Sustained Intravitreal Protein Delivery
Fulltext Access 12 Pages 2018
Inflammation is regulated by the adenosine derivative molecule, IFC-305, during reversion of cirrhosis in a CCl4 rat model
Fulltext Access 12 Pages 2018
Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation
Fulltext Access 12 Pages 2018
Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis
Fulltext Access 12 Pages 2018
Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling
Fulltext Access 12 Pages 2018
Sphingobactan, a new α-mannan exopolysaccharide from Arctic Sphingobacterium sp. IITKGP-BTPF3 capable of biological response modification
Fulltext Access 12 Pages 2018
Study of the allergenic potential of Bacillus thuringiensis Cry1Ac toxin following intra-gastric administration in a murine model of food-allergy
Fulltext Access 12 Pages 2018
Renoprotective effect of the isoflavonoid biochanin A against cisplatin induced acute kidney injury in mice: Effect on inflammatory burden and p53 apoptosis
Fulltext Access 12 Pages 2018
Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways
Fulltext Access 12 Pages 2018
Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.)
Fulltext Access 12 Pages 2018
Ancistrolikokine I and further 5,8′-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko and their cytotoxic activities against drug-sensitive and multidrug resistant human leukemia cells
Fulltext Access 12 Pages 2018
Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages
Fulltext Access 12 Pages 2018
Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer
Fulltext Access 12 Pages 2018
Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice
Fulltext Access 12 Pages 2018
Impaired glucocorticoid-mediated HPA axis negative feedback induced by juvenile social isolation in male rats
Fulltext Access 12 Pages 2018
The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption
Fulltext Access 12 Pages 2018
Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy
Fulltext Access 12 Pages 2018
Synaptic transmission and excitability during hypoxia with inflammation and reoxygenation in hippocampal CA1 neurons
Fulltext Access 12 Pages 2018
Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma
Fulltext Access 12 Pages 2018
PEGylation of Carbonate Apatite Nanoparticles Prevents Opsonin Binding and Enhances Tumor Accumulation of Gemcitabine
Fulltext Access 12 Pages 2018
Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages
Fulltext Access 12 Pages 2018
(-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor
Fulltext Access 13 Pages 2018
Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation
Fulltext Access 13 Pages 2018
Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy
Fulltext Access 13 Pages 2018
Sustained β-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation
Fulltext Access 13 Pages 2018
Chronical treatment with sildenafil causes Achilles tendinopathy in rats
Fulltext Access 13 Pages 2018
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