Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery Fulltext Access 13 Pages 2018
Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma Fulltext Access 13 Pages 2018
Research progress in stroke-induced immunodepression syndrome (SIDS) and stroke-associated pneumonia (SAP) Fulltext Access 13 Pages 2018
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals Fulltext Access 14 Pages 2018
TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy Fulltext Access 14 Pages 2018
Detailed investigation of anticancer activity of sulfamoyl benz(sulfon)amides and 1H-pyrazol-4-yl benzamides: An experimental and computational study Fulltext Access 14 Pages 2018
A Randomized Phase I Study Comparing the Pharmacokinetics of HD201, a Trastuzumab Biosimilar, With European Union-sourced Herceptin Fulltext Access 14 Pages 2018
Burden of Acute Myeloid Leukemia Among Older, Newly Diagnosed Patients: Retrospective Analysis of Data From the 2010-2012 Medicare Limited Data Set Fulltext Access 14 Pages 2018
Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome Fulltext Access 14 Pages 2018
Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety Fulltext Access 14 Pages 2018
The venom of spider Haplopelma hainanum suppresses proliferation and induces apoptosis in hepatic cancer cells by caspase activation in vitro Fulltext Access 14 Pages 2018
Zingerone ameliorates cisplatinâinduced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats Fulltext Access 14 Pages 2018
Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies Fulltext Access 14 Pages 2018
Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR Fulltext Access 14 Pages 2018
Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery Fulltext Access 14 Pages 2018
Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products Fulltext Access 14 Pages 2018
Cardio-supportive devices (VRD & DCC device) and patches for advanced heart failure: A review, summary of state of the art and future directions Fulltext Access 14 Pages 2018
Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation Fulltext Access 14 Pages 2018
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms Fulltext Access 14 Pages 2018
Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice Fulltext Access 14 Pages 2018
Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension Fulltext Access 14 Pages 2018
Activity of rutin, a potent flavonoid against SSG-sensitive and -resistant Leishmania donovani parasites in experimental leishmaniasis Fulltext Access 14 Pages 2018
Synergistic activity of imatinib and AR-42 against chronic myeloid leukemia cells mainly through HDAC1 inhibition Fulltext Access 14 Pages 2018
Clinical outcomes of intravesical injections of botulinum toxin type A in patients with refractory idiopathic overactive bladder Fulltext Access 14 Pages 2018
Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites Fulltext Access 14 Pages 2018
Double-blind randomized placebo-controlled trial on efficacy and safety of Lactuca sativa L. seeds on pregnancy-related insomnia Fulltext Access 14 Pages 2018
Acute toxicity of water and aqueous extract of soils from Champotón river in Lactuca sativa L. Fulltext Access 14 Pages 2018
The most important inferences from the Ekaterinburg nanotoxicology team's animal experiments assessing adverse health effects of metallic and metal oxide nanoparticles Fulltext Access 14 Pages 2018
Toxicity and cardiac effects of acute exposure to tryptophan metabolites on the kynurenine pathway in early developing zebrafish (Danio rerio) embryos Fulltext Access 14 Pages 2018
Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans Fulltext Access 14 Pages 2018
Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism Fulltext Access 14 Pages 2018
Circular RNA and its mechanisms in disease: From the bench to the clinic Fulltext Access 14 Pages 2018
Targeting NAD+ degradation: The therapeutic potential of flavonoids for Alzheimer's disease and cognitive frailty Fulltext Access 14 Pages 2018
Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal Fulltext Access 14 Pages 2018
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity Fulltext Access 14 Pages 2018
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo Fulltext Access 14 Pages 2018
In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modeling and numerical simulations Fulltext Access 14 Pages 2018
A predictive index of biomarkers for ictogenesis from tier I safety pharmacology testing that may warrant tier II EEG studies Fulltext Access 14 Pages 2018
Anti-inflammatory effects and mechanism of the total flavonoids from Artemisia scoparia Waldst. et kit. in vitro and in vivo Fulltext Access 14 Pages 2018
Octanoic acid prevents reduction of striatal dopamine in the MPTP mouse model of Parkinson's disease Fulltext Access 14 Pages 2018
Targeting the cancer epigenome: synergistic therapy with bromodomain inhibitors Fulltext Access 14 Pages 2018
Insights from pharmacological similarity of epigenetic targets in epipolypharmacology Fulltext Access 14 Pages 2018
Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors Fulltext Access 14 Pages 2018
Mesenteric ischemia-reperfusion: an overview of preclinical drug strategies Fulltext Access 14 Pages 2018
Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations Fulltext Access 14 Pages 2018
Effect of long-term administration of ranitidine, a histamine H2 receptor antagonist, on bone metabolism in young growing rats Fulltext Access 14 Pages 2018
Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle Fulltext Access 14 Pages 2018
Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor Fulltext Access 14 Pages 2018
Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion Fulltext Access 14 Pages 2018
Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model Fulltext Access 14 Pages 2018
Anatomical recovery of the GABAergic system after a complete spinal cord injury in lampreys Fulltext Access 14 Pages 2018
Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases Fulltext Access 14 Pages 2018
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study Fulltext Access 14 Pages 2018
Physalis alkekengi L. var. franchetii (Mast.) Makino: An ethnomedical, phytochemical and pharmacological review Fulltext Access 15 Pages 2018
Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases Fulltext Access 15 Pages 2018
Progress in the development of nanosensitizers for X-ray-induced photodynamic therapy Fulltext Access 15 Pages 2018
Changes in DNA integrity and gene expression in ovarian follicular cells of lipopolysaccharide-treated female mice Fulltext Access 15 Pages 2018
Use of CRISPR/Cas9 gene-editing tools for developing models in drug discovery Fulltext Access 15 Pages 2018
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics Fulltext Access 15 Pages 2018
Microfluidic platforms for modeling biological barriers in the circulatory system Fulltext Access 15 Pages 2018
Are valved holding chambers (VHCs) interchangeable? An in vitro evaluation of VHC equivalence Fulltext Access 15 Pages 2018
Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure Fulltext Access 15 Pages 2018
Effects of lipoic acid and n-3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause Fulltext Access 15 Pages 2018
Amaranthus caudatus extract inhibits the invasion of E. coli into uroepithelial cells Fulltext Access 15 Pages 2018
Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine Fulltext Access 15 Pages 2018
A highly sensitive and selective high pressure liquid chromatography with tandem mass spectrometry (HPLC/MS-MS) method for the direct peptide reactivity assay (DPRA) Fulltext Access 15 Pages 2018
In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis Fulltext Access 15 Pages 2018
Reprint of: Efficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: An umbrella review on various CAM approaches Fulltext Access 15 Pages 2018
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain Fulltext Access 15 Pages 2018
The role of adjuvant immunomodulatory agents for treatment of severe influenza Fulltext Access 15 Pages 2018
Rapid characterization of metabolites in soybean using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) and screening for α-glucosidase inhibitory and ant Fulltext Access 15 Pages 2018
Dichotomous function of IL-33 in health and disease: From biology to clinical implications Fulltext Access 15 Pages 2018
Drug targets exploited in Mycobacterium tuberculosis: Pitfalls and promises on the horizon Fulltext Access 15 Pages 2018
Extensions of the mTPI and TEQR designs to include non-monotone efficacy in addition to toxicity for optimal dose determination for early phase immunotherapy oncology trials Fulltext Access 15 Pages 2018
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy Fulltext Access 15 Pages 2018
Syringaresinol suppresses excitatory synaptic transmission and picrotoxin-induced epileptic activity in the hippocampus through presynaptic mechanisms Fulltext Access 15 Pages 2018
Liver X receptor β in the hippocampus: A potential novel target for the treatment of major depressive disorder? Fulltext Access 15 Pages 2018
Prenatal nicotine exposure alters postsynaptic AMPA receptors and glutamate neurotransmission within the laterodorsal tegmentum (LDT) of juvenile mice Fulltext Access 15 Pages 2018
An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds Fulltext Access 15 Pages 2018
Metyrapone prevents acute glucose hypermetabolism and short-term brain damage induced by intrahippocampal administration of 4-aminopyridine in rats Fulltext Access 15 Pages 2018
Cooperative and dissociable involvement of the nucleus accumbens core and shell in the promotion and inhibition of actions during active and inhibitory avoidance Fulltext Access 15 Pages 2018
A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants Fulltext Access 15 Pages 2018
Bioequivalence of Dapagliflozin/Metformin Extended-release Fixed-combination Drug Product and Single-component Dapagliflozin and Metformin Extended-release Tablets in Healthy Russian Subjects Fulltext Access 15 Pages 2018
Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014 Fulltext Access 15 Pages 2018
Progression-free Survival With First-line Endocrine-based Therapies Among Postmenopausal Women With HR+/HER2- Metastatic Breast Cancer: Fulltext Access 15 Pages 2018
An Elemental Impurities Excipient Database: A Viable Tool for ICH Q3D Drug Product Risk Assessment Fulltext Access 15 Pages 2018
Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis Fulltext Access 15 Pages 2018
Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy Fulltext Access 15 Pages 2018
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges Fulltext Access 15 Pages 2018