Neutrophils contribute to the pathogenesis of hemorrhagic cystitis induced by ifosfamide Fulltext Access 13 Pages 2018
ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR Fulltext Access 13 Pages 2018
Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test Fulltext Access 13 Pages 2018
Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-β/Smad signaling pathways Fulltext Access 13 Pages 2018
Baccharis trimera protects against ethanol induced hepatotoxicity in vitro and in vivo Fulltext Access 13 Pages 2018
Efficacy and safety of Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham for menopausal women: A systematic review of clinical trials and the way forward Fulltext Access 13 Pages 2018
Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis Fulltext Access 13 Pages 2018
Antimycobacterial and hypolipemiant activities of Bidens odorata (Cavanilles) Fulltext Access 13 Pages 2018
Assessment of toxicity and differential antimicrobial activity of methanol extract of rhizome of Simaba ferruginea A. St.-Hil. and its isolate canthin-6-one Fulltext Access 13 Pages 2018
Arbutus unedo L.: From traditional medicine to potential uses in modern pharmacotherapy Fulltext Access 13 Pages 2018
Clinical efficacy and safety of CIK plus radiotherapy for lung cancer: A meta-analysis of 16 randomized controlled trials Fulltext Access 13 Pages 2018
Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia Fulltext Access 13 Pages 2018
Kujigamberol interferes with pro-inflammatory cytokine-induced expression of and N-glycan modifications to cell adhesion molecules at different stages in human umbilical vein endothelial cells Fulltext Access 13 Pages 2018
A chlorogenic acid-phospholipid complex ameliorates post-myocardial infarction inflammatory response mediated by mitochondrial reactive oxygen species in SAMP8 mice Fulltext Access 13 Pages 2018
Efficacy and safety of biologics targeting IL-17 and IL-23 in the treatment of moderate-to-severe plaque psoriasis: A systematic review and meta-analysis of randomized controlled trials Fulltext Access 13 Pages 2018
Allergenicity assessment of Buchanania lanzan protein extract in Balb/c mice Fulltext Access 13 Pages 2018
UHPLC-Q-TOF-MS/MS based screening and identification of the metabolites in vivo after oral administration of betulin Fulltext Access 13 Pages 2018
A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis Fulltext Access 13 Pages 2018
Glycyrrhizin induces reactive oxygen species-dependent apoptosis and cell cycle arrest at G0/G1 in HPV18+ human cervical cancer HeLa cell line Fulltext Access 13 Pages 2018
Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase Fulltext Access 13 Pages 2018
Effects of safflower yellow on beta-amyloid deposition and activation of astrocytes in the brain of APP/PS1 transgenic mice Fulltext Access 13 Pages 2018
Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution Fulltext Access 13 Pages 2018
Zhen-wu-tang protects against podocyte injury in rats with IgA nephropathy via PPARγ/NF-κB pathway Fulltext Access 13 Pages 2018
Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats Fulltext Access 13 Pages 2018
Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line Fulltext Access 13 Pages 2018
Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis Fulltext Access 13 Pages 2018
Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus Fulltext Access 13 Pages 2018
Neural network and deep-learning algorithms used in QSAR studies: merits and drawbacks Fulltext Access 13 Pages 2018
Tatarinan N inhibits osteoclast differentiation through attenuating NF-κB, MAPKs and Ca2+-dependent signaling Fulltext Access 13 Pages 2018
Elimination of Vertical Transmission of Hepatitis B in Africa: A Review of Available Tools and New Opportunities Fulltext Access 13 Pages 2018
Oenothera rosea L´Hér. ex Ait attenuates acute colonic inflammation in TNBS-induced colitis model in rats: in vivo and in silico myeloperoxidase role Fulltext Access 13 Pages 2018
U-BIOPRED: evaluation of the value of a public-private partnership to industry Fulltext Access 13 Pages 2018
Morphine regulates adult neurogenesis and contextual memory extinction via the PKCε/Prox1 pathway Fulltext Access 13 Pages 2018
The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory Fulltext Access 13 Pages 2018
Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway Fulltext Access 13 Pages 2018
The emerging roles of the polycistronic miR-106bâ¼25 cluster in cancer - A comprehensive review Fulltext Access 13 Pages 2018
Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement Fulltext Access 13 Pages 2018
Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis Fulltext Access 13 Pages 2018
Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys Fulltext Access 13 Pages 2018
Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death Fulltext Access 13 Pages 2018
Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-β-Smad signaling pathway Fulltext Access 13 Pages 2018
Low, but not high, dose triptolide controls neuroinflammation and improves behavioral deficits in toxic model of multiple sclerosis by dampening of NF-κB activation and acceleration of intrinsic myelin repair Fulltext Access 13 Pages 2018
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans? Fulltext Access 13 Pages 2018
Differentiation of sow and mouse ovarian granulosa cells exposed to zearalenone in vitro using RNA-seq gene expression Fulltext Access 13 Pages 2018
Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells Fulltext Access 13 Pages 2018
Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease Fulltext Access 13 Pages 2018
Neurometabolite levels in antipsychotic-naïve/free patients with schizophrenia: A systematic review and meta-analysis of 1H-MRS studies Fulltext Access 13 Pages 2018
Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators? Fulltext Access 13 Pages 2018
Functional significance of O-GlcNAc modification in regulating neuronal properties Fulltext Access 13 Pages 2018
C-Phycocyanin: Cellular targets, mechanisms of action and multi drug resistance in cancer Fulltext Access 13 Pages 2018
Small conductance calcium activated potassium (SK) channel dependent and independent effects of riluzole on neuropathic pain-related amygdala activity and behaviors in rats Fulltext Access 13 Pages 2018
Cocaine-induced epigenetic DNA modification in mouse addiction-specific and non-specific tissues Fulltext Access 13 Pages 2018
The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation Fulltext Access 13 Pages 2018
Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin® UFL2 Fulltext Access 13 Pages 2018
Coamorphous Active Pharmaceutical Ingredient-Small Molecule Mixtures: Considerations in the Choice of Coformers for Enhancing Dissolution and Oral Bioavailability Fulltext Access 13 Pages 2018
Development of Novel Indole-3-Aldehyde-Loaded Gastro-Resistant Spray-Dried Microparticles for Postbiotic Small Intestine Local Delivery Fulltext Access 13 Pages 2018
Targeting non-small cell lung cancer with small-molecule EGFR tyrosine kinase inhibitors Fulltext Access 13 Pages 2018
Exenatide modulates metalloproteinase expression in human cardiac smooth muscle cells via the inhibition of Akt signaling pathway Fulltext Access 13 Pages 2018
Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β Fulltext Access 13 Pages 2018
Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway Fulltext Access 13 Pages 2018
Effect of isothiocyanates, BITC and PEITC, on stress protein accumulation, protein aggregation and aggresome-like structure formation in Xenopus A6 kidney epithelial cells Fulltext Access 13 Pages 2018
Effects of exposure to BPF on development and sexual differentiation during early life stages of zebrafish (Danio rerio) Fulltext Access 13 Pages 2018
Zebrafish (Danio rerio): A valuable tool for predicting the metabolism of xenobiotics in humans? Fulltext Access 13 Pages 2018
Factors associated with direct health care costs in schizophrenia: Results from the FACE-SZ French dataset Fulltext Access 13 Pages 2018
The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort Fulltext Access 13 Pages 2018
The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers Fulltext Access 13 Pages 2018
Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD Fulltext Access 13 Pages 2018
An in vitro investigation of indigenous South African medicinal plants used to treat oral infections Fulltext Access 13 Pages 2018
Investigation of the preventive effect of Sijunzi decoction on mitomycin C-induced immunotoxicity in rats by 1H NMR and MS-based untargeted metabolomic analysis Fulltext Access 13 Pages 2018
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response Fulltext Access 13 Pages 2018
A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids Fulltext Access 13 Pages 2018
The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment Fulltext Access 13 Pages 2018
Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo/Dx in the presence of newly synthesized phenothiazine derivatives Fulltext Access 13 Pages 2018
Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin like growth factor 1 receptor Fulltext Access 13 Pages 2018
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker Fulltext Access 13 Pages 2018
Acylated ghrelin induces but deacylated ghrelin prevents hepatic steatosis and insulin resistance in lean rats: Effects on DAG/ PKC/JNK pathway Fulltext Access 13 Pages 2018
Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview Fulltext Access 13 Pages 2018
LST-3TM12 is a member of the OATP1B family and a functional transporter Fulltext Access 13 Pages 2018
STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB Fulltext Access 13 Pages 2018
Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity Fulltext Access 13 Pages 2018
Gangjihwan, a polyherbal composition, inhibits fat accumulation through the modulation of lipogenic transcription factors SREBP1C, PPARγ and C/EBPα Fulltext Access 13 Pages 2018
A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway Fulltext Access 13 Pages 2018
Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation Fulltext Access 13 Pages 2018
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies Fulltext Access 13 Pages 2018
Establishment of intracellular tenofovir-diphosphate as the key determinant for in vitro-in vivo translation of antiviral efficacy Fulltext Access 13 Pages 2018
A gender- and culturally-sensitive weight loss intervention for Hispanic males: The ANIMO randomized controlled trial pilot study protocol and recruitment methods Fulltext Access 13 Pages 2018
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) Fulltext Access 13 Pages 2018
Kainate receptor mediated presynaptic LTP in agranular insular cortex contributes to fear and anxiety in mice Fulltext Access 13 Pages 2018
MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies Fulltext Access 13 Pages 2018
Role of nitric oxide and WNK-SPAK/OSR1-KCC2 signaling in daily changes in GABAergic inhibition in the rat dorsal raphe neurons Fulltext Access 13 Pages 2018