The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review Fulltext Access 57 Pages 2018
Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness Fulltext Access 57 Pages 2018
How Predictable Are Human Stratum Corneum Lipid/Water Partition Coefficients? Assessment and Useful Correlations for Dermal Absorption Fulltext Access 57 Pages 2018
Natural product-derived compounds in HIV suppression, remission, and eradication strategies Fulltext Access 57 Pages 2018
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress Fulltext Access 57 Pages 2018
From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives Fulltext Access 57 Pages 2018
Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice Fulltext Access 58 Pages 2018
Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC Fulltext Access 58 Pages 2018
Role of transglutaminase 2 in A1 adenosine receptor- and β2-adrenoceptor-mediated pharmacological pre- and post-conditioning against hypoxia-reoxygenation-induced cell death in H9c2 cells Fulltext Access 58 Pages 2018
TGF3L fusion enhances the antitumor activity of TRAIL by promoting assembly into polymers Fulltext Access 58 Pages 2018
Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium Fulltext Access 58 Pages 2018
GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription Fulltext Access 58 Pages 2018
Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain Fulltext Access 58 Pages 2018
Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects Fulltext Access 58 Pages 2018
Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC Fulltext Access 58 Pages 2018
Angiogenic lncRNAs: A potential therapeutic target for ischaemic heart disease Fulltext Access 58 Pages 2018
Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay Fulltext Access 58 Pages 2018
Probing structure-activity relationship in β-arrestin2 recruitment of diversely substituted adenosine derivatives Fulltext Access 58 Pages 2018
Ferulic acid-loaded nanostructured lipid carriers: A promising nanoformulation against the ischemic neural injuries Fulltext Access 59 Pages 2018
Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs Fulltext Access 59 Pages 2018
Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment Fulltext Access 59 Pages 2018
BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots Fulltext Access 59 Pages 2018
Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology Fulltext Access 59 Pages 2018
Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells Fulltext Access 59 Pages 2018
Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice Fulltext Access 59 Pages 2018
The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse Fulltext Access 59 Pages 2018
Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol Fulltext Access 59 Pages 2018
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy Fulltext Access 60 Pages 2018
Mesoporous silica nanoparticles: a smart nanosystem for management of breast cancer Fulltext Access 60 Pages 2018
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development Fulltext Access 60 Pages 2018
GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice Fulltext Access 60 Pages 2018
Anti-neuroinflammatory effect of 6,8,1â²-tri-O-methylaverantin, a metabolite from a marine-derived fungal strain Aspergillus sp., via upregulation of heme oxygenase-1 in lipopolysaccharide-activated microglia Fulltext Access 60 Pages 2018
The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia Fulltext Access 60 Pages 2018
Behavioral, cellular and molecular maladaptations covary with exposure to pyridostigmine bromide in a rat model of gulf war illness pain Fulltext Access 60 Pages 2018
Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities Fulltext Access 60 Pages 2018
Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic Fulltext Access 60 Pages 2018
Gastrodin attenuates microglia activation through renin-angiotensin system and Sirtuin3 pathway Fulltext Access 61 Pages 2018
Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons Fulltext Access 61 Pages 2018
Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression Fulltext Access 61 Pages 2018
The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine-related neuropsychiatric disorders: Rationale and current status of research Fulltext Access 61 Pages 2018
Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase Fulltext Access 61 Pages 2018
Characterization and comparison of activity profiles exhibited by the cave and surface morphotypes of the blind Mexican tetra, Astyanax mexicanus Fulltext Access 61 Pages 2018
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination Fulltext Access 62 Pages 2018
Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells Fulltext Access 62 Pages 2018
A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis Fulltext Access 62 Pages 2018
Wnt signaling in bone metastasis: mechanisms and therapeutic opportunities Fulltext Access 62 Pages 2018
Subgenomic flaviviral RNAs: What do we know after the first decade of research Fulltext Access 63 Pages 2018
l-Dopa treatment during perinatal development leads to different behavioral alterations in female vs. male juvenile Swiss mice Fulltext Access 63 Pages 2018
Exploring the effects of DPP-4 inhibitors on the kidney from the bench to clinical trials Fulltext Access 64 Pages 2018
The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression Fulltext Access 64 Pages 2018
mRNA transfection retrofits cell-based assays with xenobiotic metabolism Fulltext Access 65 Pages 2018
Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments Fulltext Access 65 Pages 2018
Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6 Fulltext Access 65 Pages 2018
Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline Fulltext Access 65 Pages 2018
Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease Fulltext Access 66 Pages 2018
Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin Fulltext Access 67 Pages 2018
Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease Fulltext Access 67 Pages 2018
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy Fulltext Access 67 Pages 2018
Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor Fulltext Access 67 Pages 2018
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway Fulltext Access 68 Pages 2018
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology Fulltext Access 68 Pages 2018
Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review Fulltext Access 68 Pages 2018
Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress Fulltext Access 68 Pages 2018
Fostering efficacy and toxicity evaluation of traditional Chinese medicine and natural products: Chick embryo as a high throughput model bridging in vitro and in vivo studies Fulltext Access 68 Pages 2018
Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice Fulltext Access 69 Pages 2018
Evidence of traditionality of Brazilian medicinal plants: The case studies of Stryphnodendron adstringens (Mart.) Coville (barbatimão) barks and Copaifera spp. (copaÃba) oleoresin in wound healing Fulltext Access 69 Pages 2018
Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding Fulltext Access 69 Pages 2018
Mechanism underlying NMDA blockade-induced inhibition of aggression in post-weaning socially isolated mice Fulltext Access 70 Pages 2018
Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers Fulltext Access 70 Pages 2018
The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen Fulltext Access 70 Pages 2018
Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review Fulltext Access 70 Pages 2018
iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility Fulltext Access 71 Pages 2018
DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na+-K+-ATPase, inhibiting Na+-K+-ATPase/ROS pathway and activating PI3K/Akt and ERK1/2 Fulltext Access 71 Pages 2018
The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders Fulltext Access 71 Pages 2018
H2S and polysulfide metabolism: Conventional and unconventional pathways Fulltext Access 71 Pages 2018
Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs) Fulltext Access 72 Pages 2018
BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats Fulltext Access 74 Pages 2018
Readers of DNA methylation, the MBD family as potential therapeutic targets Fulltext Access 74 Pages 2018
Potential therapeutic applications of the genus Annona: Local and traditional uses and pharmacology Fulltext Access 74 Pages 2018
Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance Fulltext Access 75 Pages 2018
Targeting oncogenic Raf protein-serine/threonine kinases in human cancers Fulltext Access 75 Pages 2018
Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search Fulltext Access 75 Pages 2018
The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology Fulltext Access 76 Pages 2018
Penehyclidine hydrochloride preconditioning provides pulmonary and systemic protection in a rat model of lung ischaemia reperfusion injury Fulltext Access 76 Pages 2018
Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children Fulltext Access 76 Pages 2018
Nucleosidic DNA demethylating epigenetic drugs - A comprehensive review from discovery to clinic Fulltext Access 78 Pages 2018