Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells Fulltext Access 50 Pages 2018
Activation of autophagy by stress-activated signals as a cellular self-defense mechanism against the cytotoxic effects of MBIC in human breast cancer cells in vitro Fulltext Access 50 Pages 2018
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner Fulltext Access 50 Pages 2018
Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice Fulltext Access 50 Pages 2018
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk Fulltext Access 50 Pages 2018
BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications Fulltext Access 50 Pages 2018
Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3â/â mice transplanted with human PBMCs Fulltext Access 50 Pages 2018
Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations Fulltext Access 51 Pages 2018
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich protein kinases (SRPK) in murine melanoma Fulltext Access 51 Pages 2018
Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species Fulltext Access 51 Pages 2018
Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway Fulltext Access 51 Pages 2018
Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models Fulltext Access 51 Pages 2018
Enhanced anticancer effects of Scutellaria barbata D. Don in combination with traditional Chinese medicine components on non-small cell lung cancer cells Fulltext Access 51 Pages 2018
Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone Fulltext Access 51 Pages 2018
Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors Fulltext Access 51 Pages 2018
Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18F-fuorodeoxyglucose Fulltext Access 51 Pages 2018
Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson's disease symptoms Fulltext Access 51 Pages 2018
Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism Fulltext Access 51 Pages 2018
Peripheral 5-HT3 mediates mirror-image pain by a cross-talk with acid-sensing ion channel 3 Fulltext Access 51 Pages 2018
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy Fulltext Access 51 Pages 2018
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice Fulltext Access 51 Pages 2018
The role of angiotensin II in cancer metastasis: Potential of renin-angiotensin system blockade as a treatment for cancer metastasis Fulltext Access 51 Pages 2018
The tumor antagonistic steroidal alkaloid Solanidine prompts the intrinsic suicidal signal mediated DFF-40 nuclear import and nucleosomal disruption Fulltext Access 51 Pages 2018
Cellular, transcriptomic and methylome effects of individual and combined exposure to BPA, BPF, BPS on mouse spermatocyte GC-2 cell line Fulltext Access 51 Pages 2018
Adipokine apelin ameliorates chronic colitis in Il-10â/â mice by promoting intestinal lymphatic functions Fulltext Access 51 Pages 2018
Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS) Fulltext Access 51 Pages 2018
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection Fulltext Access 52 Pages 2018
p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism Fulltext Access 52 Pages 2018
BAY 60-2770 activates two isoforms of nitric oxide sensitive guanylyl cyclase: Evidence for stable insertion of activator drugs Fulltext Access 52 Pages 2018
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines Fulltext Access 52 Pages 2018
Exogenous oxidants activate nuclear factor kappa B through Toll-like receptor 4 stimulation to maintain inflammatory phenotype in macrophage Fulltext Access 52 Pages 2018
Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease Fulltext Access 52 Pages 2018
Sirtuin activators and inhibitors: Promises, achievements, and challenges Fulltext Access 52 Pages 2018
Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics Fulltext Access 52 Pages 2018
(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray Fulltext Access 52 Pages 2018
Substituents at the C3â² and C3â²N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel Fulltext Access 52 Pages 2018
Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses Fulltext Access 52 Pages 2018
MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats Fulltext Access 52 Pages 2018
Recombinant tissue plasminogen activator induces long-term anxiety-like behaviors via the ERK1/2-GAD1-GABA cascade in the hippocampus of a rat model Fulltext Access 52 Pages 2018
Targeting central β2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice Fulltext Access 52 Pages 2018
Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin Fulltext Access 53 Pages 2018
Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation Fulltext Access 53 Pages 2018
Cardiac voltage gated calcium channels and their regulation by β-adrenergic signaling Fulltext Access 53 Pages 2018
Fluoxetine protects against OVA induced bronchial asthma and depression in rats Fulltext Access 53 Pages 2018
Effect of sildenafil citrate treatment in the eNOS knockout mouse model of fetal growth restriction on long-term cardiometabolic outcomes in male offspring Fulltext Access 53 Pages 2018
Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors Fulltext Access 53 Pages 2018
On the G protein-coupling selectivity of the native A2B adenosine receptor Fulltext Access 53 Pages 2018
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy Fulltext Access 53 Pages 2018
Effects of CB1 receptor antagonism and stress exposures in adolescence on socioemotional behaviours, neuroendocrine stress responses, and expression of relevant proteins in the hippocampus and prefrontal cortex in rats Fulltext Access 53 Pages 2018
Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders Fulltext Access 53 Pages 2018
The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach Fulltext Access 54 Pages 2018
A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines Fulltext Access 54 Pages 2018
Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges Fulltext Access 54 Pages 2018
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition Fulltext Access 54 Pages 2018
Tocotrienols: The promising analogues of vitamin E for cancer therapeutics Fulltext Access 54 Pages 2018
Effects of Mg2+ on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site Fulltext Access 54 Pages 2018
Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history Fulltext Access 54 Pages 2018
Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors Fulltext Access 54 Pages 2018
Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling Fulltext Access 54 Pages 2018
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor Fulltext Access 54 Pages 2018
Strategies and limitations associated with in vitro characterization of vitamin D receptor activators Fulltext Access 54 Pages 2018
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients Fulltext Access 54 Pages 2018
Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation Fulltext Access 54 Pages 2018
Stimulatory effect of desipramine on lung metastases of adenocarcinoma MADB 106 in stress highly-sensitive and stress non-reactive rats Fulltext Access 55 Pages 2018
Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway Fulltext Access 55 Pages 2018
Genome-wide identification and analysis of Nrf2 binding sites - Antioxidant response elements in zebrafish Fulltext Access 55 Pages 2018
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice Fulltext Access 55 Pages 2018
Glutaminase-1 stimulates the proliferation, migration, and survival of human endothelial cells Fulltext Access 55 Pages 2018
Inhibition of influenza A virus by mixed siRNAs, targeting the PA, NP, and NS genes, delivered by hybrid microcarriers Fulltext Access 55 Pages 2018
Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug Fulltext Access 55 Pages 2018
Restorative effect of l-Dopa treatment against Ochratoxin A induced neurotoxicity Fulltext Access 55 Pages 2018
Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice Fulltext Access 55 Pages 2018
Intranasally delivered small interfering RNA-mediated suppression of scavenger receptor Mac-1 attenuates microglial phenotype switching and working memory impairment following hypoxia Fulltext Access 55 Pages 2018
Elucidation of the neural circuits activated by a GABAB receptor positive modulator: Relevance to anxiety Fulltext Access 55 Pages 2018
Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina Fulltext Access 55 Pages 2018
Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system Fulltext Access 55 Pages 2018
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine Fulltext Access 55 Pages 2018
Atorvastatin impaired glucose metabolism in C2C12 cells partly via inhibiting cholesterol-dependent glucose transporter 4 translocation Fulltext Access 55 Pages 2018
Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation Fulltext Access 55 Pages 2018
Tithonia diversifolia (Hemsl.) A. Gray as a medicinal plant: A comprehensive review of its ethnopharmacology, phytochemistry, pharmacotoxicology and clinical relevance Fulltext Access 55 Pages 2018
Receptor binding kinetics equations: Derivation using the Laplace transform method Fulltext Access 55 Pages 2018
Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction Fulltext Access 56 Pages 2018
Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization Fulltext Access 56 Pages 2018
The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease Fulltext Access 56 Pages 2018
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes Fulltext Access 56 Pages 2018
An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome Fulltext Access 56 Pages 2018
Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors Fulltext Access 56 Pages 2018
Further investigation of the effects of 5-hydroxytryptamine, 8-OH-DPAT and DOI to mediate contraction and relaxation responses in the intestine and emesis in Suncus murinus Fulltext Access 56 Pages 2018
Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway Fulltext Access 56 Pages 2018
Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review Fulltext Access 56 Pages 2018
The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells Fulltext Access 56 Pages 2018
Ethnoveterinary botanical survey of medicinal plants in Abergelle, Sekota and Lalibela districts of Amhara region, Northern Ethiopia Fulltext Access 56 Pages 2018