Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway Fulltext Access 47 Pages 2018
CINPA1 binds directly to constitutive androstane receptor and inhibits its activity Fulltext Access 47 Pages 2018
Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells Fulltext Access 47 Pages 2018
DSP-6952, a novel 5-HT4 receptor partial agonist, inhibits visceral hypersensitivity and ameliorates gastrointestinal dysfunction in experimental animals Fulltext Access 47 Pages 2018
Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases Fulltext Access 47 Pages 2018
In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis Fulltext Access 47 Pages 2018
A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance Fulltext Access 47 Pages 2018
Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells Fulltext Access 47 Pages 2018
An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats Fulltext Access 47 Pages 2018
Single-tube biosynthesis and extraction of U-13C and U-14C arachidonic acid from microcultures of Mortierella alpina for in vivo pharmacology and metabolic tracing studies Fulltext Access 47 Pages 2018
Important roles of the Ca2+-sensing receptor in vascular health and disease Fulltext Access 47 Pages 2018
Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice Fulltext Access 47 Pages 2018
Blockade of serotonin 5-HT2A receptors potentiates dopamine D2 activation-induced disruption of pup retrieval on an elevated plus maze, but has no effect on D2 blockade-induced one Fulltext Access 47 Pages 2018
Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3 Fulltext Access 47 Pages 2018
Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum Fulltext Access 47 Pages 2018
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases Fulltext Access 47 Pages 2018
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice Fulltext Access 47 Pages 2018
Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS Fulltext Access 47 Pages 2018
Adenosine activates Gαs proteins and inhibits C3a-induced activation of human mast cells Fulltext Access 47 Pages 2018
Smiglaside A ameliorates LPS-induced acute lung injury by modulating macrophage polarization via AMPK-PPARγ pathway Fulltext Access 47 Pages 2018
Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists Fulltext Access 47 Pages 2018
Neuronal Growth Factor regulates Brain Specific Kinase 1 expression by inhibiting promoter methylation and promoting Sp1 recruitment Fulltext Access 47 Pages 2018
Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK-3β/TNF-α pathway Fulltext Access 47 Pages 2018
Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes Fulltext Access 47 Pages 2018
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood Fulltext Access 47 Pages 2018
Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation Fulltext Access 47 Pages 2018
Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening Fulltext Access 47 Pages 2018
Immunomodulatory tetracyclines ameliorate DNBS-colitis: Impact on microRNA expression and microbiota composition Fulltext Access 47 Pages 2018
Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds Fulltext Access 47 Pages 2018
Hantavirus Gc induces long-term immune protection via LAMP-targeting DNA vaccine strategy Fulltext Access 47 Pages 2018
A-type K+ channels impede supralinear summation of clustered glutamatergic inputs in layer 3 neocortical pyramidal neurons Fulltext Access 48 Pages 2018
Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC-LTQ-Orbitrap, ADME prediction and network target analysis Fulltext Access 48 Pages 2018
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex Fulltext Access 48 Pages 2018
Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways Fulltext Access 48 Pages 2018
Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study Fulltext Access 48 Pages 2018
Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches Fulltext Access 48 Pages 2018
Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac Fulltext Access 48 Pages 2018
The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice Fulltext Access 48 Pages 2018
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition Fulltext Access 48 Pages 2018
Protective roles of fenofibrate against cisplatin-induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction Fulltext Access 48 Pages 2018
Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis Fulltext Access 48 Pages 2018
n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation Fulltext Access 48 Pages 2018
Hepatoprotective effects of green Capsicum annum against ethanol induced oxidative stress, inflammation and apoptosis in rats Fulltext Access 48 Pages 2018
PFOS-induced excitotoxicity is dependent on Ca2+ influx via NMDA receptors in rat cerebellar granule neurons Fulltext Access 48 Pages 2018
In Vitro-In Vivo Correlations of Carbamazepine Nanodispersions for Application in Formulation Development Fulltext Access 48 Pages 2018
Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation Fulltext Access 48 Pages 2018
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions Fulltext Access 48 Pages 2018
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Fulltext Access 48 Pages 2018
Phytochemical and pharmacological aspects of Cnidoscolus Pohl species: A systematic review Fulltext Access 48 Pages 2018
Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons Fulltext Access 48 Pages 2018
The transcriptional response of skin to fluorescent light exposure in viviparous (Xiphophorus) and oviparous (Danio, Oryzias) fishes Fulltext Access 48 Pages 2018
Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models Fulltext Access 48 Pages 2018
MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools Fulltext Access 48 Pages 2018
Biomonitoring the cardiorenal effects of Luehea divaricata Mart.: An ethnoguided approach Fulltext Access 48 Pages 2018
Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways Fulltext Access 48 Pages 2018
Mechanism underlying the contractile activity of UTP in the mammalian heart Fulltext Access 48 Pages 2018
Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy Fulltext Access 48 Pages 2018
Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells Fulltext Access 48 Pages 2018
A behavioral mechanistic investigation of the role of 5-HT1A receptors in the mediation of rat maternal behavior Fulltext Access 49 Pages 2018
Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/- mice Fulltext Access 49 Pages 2018
Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel Fulltext Access 49 Pages 2018
Perindopril ameliorates lipopolysaccharide-induced brain injury through modulation of angiotensin-II/angiotensin-1-7 and related signaling pathways Fulltext Access 49 Pages 2018
Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations Fulltext Access 49 Pages 2018
Functional pharmacogenomics and toxicity of PolyPurine Reverse Hoogsteen hairpins directed against survivin in human cells Fulltext Access 49 Pages 2018
Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry Fulltext Access 49 Pages 2018
AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks Fulltext Access 49 Pages 2018
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice Fulltext Access 49 Pages 2018
Effects of selective serotonin-reuptake inhibitors (SSRIs) on human villous trophoblasts syncytialization Fulltext Access 49 Pages 2018
Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities Fulltext Access 49 Pages 2018
Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity Fulltext Access 49 Pages 2018
Ethnopharmacological approaches to kidney disease-prospecting an indigenous species from Brazilian Pantanal Fulltext Access 49 Pages 2018
The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity Fulltext Access 49 Pages 2018
p53 and glucose metabolism: an orchestra to be directed in cancer therapy Fulltext Access 49 Pages 2018
Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma Fulltext Access 49 Pages 2018
Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/β-catenin and NF-κB signaling pathway Fulltext Access 49 Pages 2018
Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice Fulltext Access 49 Pages 2018
Safer approaches to therapeutic modulation of TGF-β signaling for respiratory disease Fulltext Access 49 Pages 2018
Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan Fulltext Access 49 Pages 2018
Ethnopharmacological uses, phytochemistry and pharmacology of genus Adiantum: A comprehensive review Fulltext Access 50 Pages 2018
Monoamine oxidase-B inhibitor protects degenerating spinal neurons, enhances nerve regeneration and functional recovery in sciatic nerve crush injury model Fulltext Access 50 Pages 2018
Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation Fulltext Access 50 Pages 2018
Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X7 receptors Fulltext Access 50 Pages 2018
Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis Fulltext Access 50 Pages 2018
Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway Fulltext Access 50 Pages 2018
Inhibition of prostatic smooth muscle contraction by the inhibitor of G protein-coupled receptor kinase 2/3, CMPD101 Fulltext Access 50 Pages 2018
Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology Fulltext Access 50 Pages 2018
Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways Fulltext Access 50 Pages 2018
Cytotoxic effect of Kalanchoe flammea and induction of intrinsic mitochondrial apoptotic signaling in prostate cancer cells Fulltext Access 50 Pages 2018
Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia Fulltext Access 50 Pages 2018
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand Fulltext Access 50 Pages 2018
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway Fulltext Access 50 Pages 2018
Aqueous extract of Sedum oxypetalum induces mineralization and osteogenic differentiation by human Periodontal Ligament-Derived cells Fulltext Access 50 Pages 2018
Geopharmaceuticals of Himalayan Sowa Rigpa medicine: Ethnopharmacological uses, mineral diversity, chemical identification and current utilization in Bhutan Fulltext Access 50 Pages 2018
Microinjection of baclofen and CGP7930 into the ventral tegmental area suppresses alcohol self-administration in alcohol-preferring rats Fulltext Access 50 Pages 2018