Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease Fulltext Access 44 Pages 2018
IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK/p38 signaling pathway Fulltext Access 44 Pages 2018
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells Fulltext Access 44 Pages 2018
Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway Fulltext Access 44 Pages 2018
New insights about the peculiar role of the 28-38 C-terminal segment and some selected residues in PACAP for signaling and neuroprotection Fulltext Access 44 Pages 2018
CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion Fulltext Access 44 Pages 2018
Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel Fulltext Access 44 Pages 2018
KV1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity Fulltext Access 44 Pages 2018
Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans Fulltext Access 44 Pages 2018
PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 Fulltext Access 44 Pages 2018
Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine Fulltext Access 45 Pages 2018
Antihypertensive effect of the methanolic extract from Eruca sativa Mill., (Brassicaceae) in rats: Muscarinic receptor-linked vasorelaxant and cardiotonic effects Fulltext Access 45 Pages 2018
Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property Fulltext Access 45 Pages 2018
Eriodictyol stimulates insulin secretion through cAMP/PKA signaling pathway in mice islets Fulltext Access 45 Pages 2018
Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron Fulltext Access 45 Pages 2018
Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats Fulltext Access 45 Pages 2018
Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2 Fulltext Access 45 Pages 2018
The protective effect of α-lipoic acid against bisphenol A-induced neurobehavioral toxicity Fulltext Access 45 Pages 2018
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) are associated with long term tramadol treatment-induced oxidative damage and hepatotoxicity Fulltext Access 45 Pages 2018
Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior Fulltext Access 45 Pages 2018
Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition Fulltext Access 45 Pages 2018
Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2 Fulltext Access 45 Pages 2018
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria Fulltext Access 45 Pages 2018
CpAMs induce assembly of HBV capsids with altered electrophoresis mobility: Implications for mechanism of inhibiting pgRNA packaging Fulltext Access 45 Pages 2018
Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production Fulltext Access 45 Pages 2018
Astaxanthin: A mechanistic review on its biological activities and health benefits Fulltext Access 45 Pages 2018
Synthetic cannabinoid AM2201 induces seizures: Involvement of cannabinoid CB1 receptors and glutamatergic transmission Fulltext Access 45 Pages 2018
Which is the best combination of TACE and Sorafenib for advanced hepatocellular carcinoma treatment? A systematic review and network meta-analysis Fulltext Access 45 Pages 2018
Feraheme® suppresses immune function of human T lymphocytes through mitochondrial damage and mitoROS production Fulltext Access 45 Pages 2018
Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish Fulltext Access 45 Pages 2018
Bisphenol A induced male germ cell apoptosis via IFNβ-XAF1-XIAP pathway in adult mice Fulltext Access 45 Pages 2018
An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis Fulltext Access 45 Pages 2018
Immunomodulatory effects of a rationally designed peptide mimetic of human IFNβ in EAE model of multiple sclerosis Fulltext Access 45 Pages 2018
Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering Fulltext Access 45 Pages 2018
Neuregulin 1/ErbB signalling modulates hippocampal mGluRI-dependent LTD and object recognition memory Fulltext Access 45 Pages 2018
Protective effect of Juglans regia L. against ultraviolet B radiation induced inflammatory responses in human epidermal keratinocytes Fulltext Access 45 Pages 2018
Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors Fulltext Access 45 Pages 2018
CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons Fulltext Access 45 Pages 2018
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia Fulltext Access 45 Pages 2018
Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats Fulltext Access 45 Pages 2018
5-HT1A receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice Fulltext Access 45 Pages 2018
In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer Fulltext Access 45 Pages 2018
Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells Fulltext Access 45 Pages 2018
The Combination of GIS and Biphasic to Better Predict In Vivo Dissolution of BCS Class IIb Drugs, Ketoconazole and Raloxifene Fulltext Access 45 Pages 2018
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy Fulltext Access 45 Pages 2018
Recombinant mutagenic 3ABC protein and monoclonal antibody for quality-control testing in foot-and-mouth disease vaccines Fulltext Access 45 Pages 2018
Vaccination with RSV M209-223 peptide promotes a protective immune response associated with reduced pulmonary inflammation Fulltext Access 45 Pages 2018
Development of Adjuvanted Solid Fat Nanoemulsions for Pulmonary Hepatitis B Vaccination Fulltext Access 45 Pages 2018
The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines Fulltext Access 45 Pages 2018
Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation Fulltext Access 45 Pages 2018
Formulation Development, Optimization, and In Vitro-In Vivo Characterization of Natamycin-Loaded PEGylated Nano-Lipid Carriers for Ocular Applications Fulltext Access 45 Pages 2018
Integrity, standards, and QC-related issues with big data in pre-clinical drug discovery Fulltext Access 45 Pages 2018
Resveratrol loaded solid lipid nanoparticles attenuate mitochondrial oxidative stress in vascular dementia by activating Nrf2/HO-1 pathway Fulltext Access 45 Pages 2018
Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers Fulltext Access 45 Pages 2018
The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy Fulltext Access 46 Pages 2018
Age related rise in lactate and its correlation with lactate dehydrogenase (LDH) status in post-mitochondrial fractions isolated from different regions of brain in mice Fulltext Access 46 Pages 2018
Selective serotonin reuptake inhibitors affect structure, function and metabolism of skeletal muscle: A systematic review Fulltext Access 46 Pages 2018
Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects Fulltext Access 46 Pages 2018
Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio) Fulltext Access 46 Pages 2018
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin Fulltext Access 46 Pages 2018
Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty acids and fatty alcohols Fulltext Access 46 Pages 2018
Systemic administration of the bifunctional opioid/neuropeptide FF receptors agonist BN-9 produced peripheral antinociception in preclinical mouse models of pain Fulltext Access 46 Pages 2018
Antisolvent Recrystallization Strategy to Screen Appropriate Carriers to Stabilize Filgotinib Amorphous Solid Dispersions Fulltext Access 46 Pages 2018
Targeting CXCR7 improves the efficacy of breast cancer patients with tamoxifen therapy Fulltext Access 46 Pages 2018
Potential of Cationic-Polymeric Nanoparticles for Oral Delivery of Naringenin: In Vitro and In Vivo Investigations Fulltext Access 46 Pages 2018
Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes Fulltext Access 46 Pages 2018
Anti-inflammatory effects of Zhishi and Zhiqiao revealed by network pharmacology integrated with molecular mechanism and metabolomics studies Fulltext Access 46 Pages 2018
Biofilm inhibition mechanism from extract of Hymenocallis littoralis leaves Fulltext Access 46 Pages 2018
Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway Fulltext Access 46 Pages 2018
Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver Fulltext Access 46 Pages 2018
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice Fulltext Access 46 Pages 2018
Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases Fulltext Access 46 Pages 2018
Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala2GIP in rat model of Huntington's disease Fulltext Access 46 Pages 2018
Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells Fulltext Access 46 Pages 2018
DHA supplementation prevent the progression of NASH via GPR120 signaling Fulltext Access 46 Pages 2018
Luteolin attenuates airway inflammation by inducing the transition of CD4+CD25- to CD4+CD25+ regulatory T cells Fulltext Access 46 Pages 2018
Chemical characterization and cerebroprotective effect of methanolic root extract of Colebrookea oppositifolia in rats Fulltext Access 46 Pages 2018
Millettia macrophylla (Fabaceae) phenolic fraction prevents differentiation of 3T3-L1 adipocytes and the increased risks of cardiovascular diseases in ovariectomized rats Fulltext Access 46 Pages 2018
Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits Fulltext Access 46 Pages 2018
Lafoensia pacari A. St.-Hil.: Wound healing activity and mechanism of action of standardized hydroethanolic leaves extract Fulltext Access 46 Pages 2018
Quorum sensing inhibitory potential and in silico molecular docking of flavonoids and novel terpenoids from Senegalia nigrescens Fulltext Access 46 Pages 2018
Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro Fulltext Access 46 Pages 2018
Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model Fulltext Access 46 Pages 2018
Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells Fulltext Access 46 Pages 2018
Melatonin as an endogenous regulator of diseases: The role of autophagy Fulltext Access 46 Pages 2018
Formulation Optimization of Freeze-Dried Long-Circulating Liposomes and In-Line Monitoring of the Freeze-Drying Process Using an NIR Spectroscopy Tool Fulltext Access 47 Pages 2018
Developing Quantitative In Vitro-In Vivo Correlation for Fenofibrate Immediate-Release Formulations With the Biphasic Dissolution-Partition Test Method Fulltext Access 47 Pages 2018
Inhibition of miR-21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush Fulltext Access 47 Pages 2018
Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord Fulltext Access 47 Pages 2018
DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease. Fulltext Access 47 Pages 2018