Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats Fulltext Access 40 Pages 2018
Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens Fulltext Access 40 Pages 2018
CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus Fulltext Access 40 Pages 2018
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses Fulltext Access 40 Pages 2018
GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling Fulltext Access 40 Pages 2018
In vivo assessment of neurological channelopathies: Application of peripheral nerve excitability studies Fulltext Access 40 Pages 2018
“Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA Fulltext Access 40 Pages 2018
Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats Fulltext Access 40 Pages 2018
Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram Fulltext Access 40 Pages 2018
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace Fulltext Access 40 Pages 2018
Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity Fulltext Access 40 Pages 2018
Periaqueductal gray glutamatergic, cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation Fulltext Access 40 Pages 2018
Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22â¯cells Fulltext Access 40 Pages 2018
Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts Fulltext Access 40 Pages 2018
Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy Fulltext Access 40 Pages 2018
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation Fulltext Access 40 Pages 2018
Structural and functional analysis of two novel somatostatin receptors identified from topmouth culter (Erythroculter ilishaeformis) Fulltext Access 40 Pages 2018
Folate-Conjugated Superoxide Dismutase Adsorbed Over Antioxidant Mimicking Nanomatrix Frameworks for Treatment of Rheumatoid Arthritis Fulltext Access 40 Pages 2018
Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia Fulltext Access 40 Pages 2018
Ouabain increases neuronal branching in hippocampus and improves spatial memory Fulltext Access 40 Pages 2018
Population Pharmacokinetics and Dosing Simulations of Ceftazidime in Chinese Neonates Fulltext Access 40 Pages 2018
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species Fulltext Access 40 Pages 2018
Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch⢠Microprojection Array Fulltext Access 40 Pages 2018
The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin Fulltext Access 41 Pages 2018
Amaryllidaceae alkaloids as agents with protective effects against oxidative neural cell injury Fulltext Access 41 Pages 2018
Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor β1 expression via DNA demethylation Fulltext Access 41 Pages 2018
Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes Fulltext Access 41 Pages 2018
Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells Fulltext Access 41 Pages 2018
The genus Pterocaulon (Asteraceae) - A review on traditional medicinal uses, chemical constituents and biological properties Fulltext Access 41 Pages 2018
Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma Fulltext Access 41 Pages 2018
Salusin-α attenuates hepatic steatosis and atherosclerosis in high fat diet-fed low density lipoprotein receptor deficient mice Fulltext Access 41 Pages 2018
SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries Fulltext Access 41 Pages 2018
Kinetics of oxytocin and deaminooxytocin displacement from the OXTR-receptor compartment in rat uterus ex vivo Fulltext Access 41 Pages 2018
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor Fulltext Access 41 Pages 2018
α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes Fulltext Access 41 Pages 2018
Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells Fulltext Access 41 Pages 2018
Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells Fulltext Access 41 Pages 2018
Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword Fulltext Access 41 Pages 2018
N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity Fulltext Access 41 Pages 2018
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation Fulltext Access 41 Pages 2018
Occupancy of adenosine A2A receptors by istradefylline in patients with Parkinson's disease using 11C-preladenant PET Fulltext Access 41 Pages 2018
HTLV-1 infection-induced motor dysfunction, memory impairment, depression, and brain tissues oxidative damage in female BALB/c mice Fulltext Access 41 Pages 2018
Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors Fulltext Access 41 Pages 2018
Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells Fulltext Access 41 Pages 2018
The activity of brain and liver cytochrome P450 2D (CYP2D) is differently affected by antidepressants in the chronic mild stress (CMS) model of depression in the rat Fulltext Access 41 Pages 2018
Assessing heavy metal toxicity in sediments of Chennai Coast of Tamil Nadu using Energy Dispersive X-Ray Fluorescence Spectroscopy (EDXRF) with statistical approach Fulltext Access 41 Pages 2018
Epigenetic modulation of Nrf2 and Ogg1 gene expression in testicular germ cells by methyl parathion exposure Fulltext Access 41 Pages 2018
Crosstalk mechanisms in hepatoprotection: Thyroid hormone-docosahexaenoic acid (DHA) and DHA-extra virgin olive oil combined protocols Fulltext Access 41 Pages 2018
New Bis copper complex ((Z) -4 - ((4-chlorophenyl) amino) -4-oxobut-2-enoyl) oxy): Cytotoxicity in 4T1 cells and their toxicogenic potential in Swiss mice Fulltext Access 41 Pages 2018
Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis Fulltext Access 41 Pages 2018
Ciprofloxacin Dry Powder for Inhalation (ciprofloxacin DPI): Technical design and features of an efficient drug-device combination Fulltext Access 41 Pages 2018
m-Trifluoromethyl-diphenyl diselenide promotes resilience to social avoidance induced by social defeat stress in mice: Contribution of opioid receptors and MAPKs Fulltext Access 41 Pages 2018
Antidepressant effects of creatine on amyloid β1-40-treated mice: The role of GSK-3β/Nrf2 pathway Fulltext Access 41 Pages 2018
Sorafenib suppresses TGF-β responses by inducing caveolae/lipid raft-mediated internalization/degradation of cell-surface type II TGF-β receptors: Implications in development of effective adjunctive therapy for hepatocellular carcinoma Fulltext Access 41 Pages 2018
Natural products targeting ER stress pathway for the treatment of cardiovascular diseases Fulltext Access 41 Pages 2018
Helminth infection in mice improves insulin sensitivity via modulation of gut microbiota and fatty acid metabolism Fulltext Access 41 Pages 2018
Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association Fulltext Access 41 Pages 2018
Pituitary adenylate cyclase-activating polypeptide (PACAP) signaling in the prefrontal cortex modulates cued fear learning, but not spatial working memory, in female rats Fulltext Access 41 Pages 2018
Inhibition of Organic Anion Transporting Polypeptide 1B1 and 1B3 by Betulinic Acid: Effects of Preincubation and Albumin in the Media Fulltext Access 41 Pages 2018
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain Fulltext Access 41 Pages 2018
Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature Fulltext Access 41 Pages 2018
Population Pharmacokinetics of High-Dose Methotrexate in Patients With Primary Central Nervous System Lymphoma Fulltext Access 41 Pages 2018
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex Fulltext Access 41 Pages 2018
The Use of a GroEL-BLI Biosensor to Rapidly Assess Preaggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles Fulltext Access 41 Pages 2018
Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397 Fulltext Access 41 Pages 2018
Tamarix hohenackeri Bunge exerts anti-inflammatory effects on lipopolysaccharide-activated microglia in vitro Fulltext Access 41 Pages 2018
The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression Fulltext Access 41 Pages 2018
Nasal route favors the induction of CD4+ T cell responses in the liver of HBV-carrier mice immunized with a recombinant hepatitis B surface- and core-based therapeutic vaccine Fulltext Access 41 Pages 2018
α-(phenylselanyl) acetophenone abolishes acute restraint stress induced-comorbid pain, depression and anxiety-related behaviors in mice Fulltext Access 41 Pages 2018
Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers Fulltext Access 41 Pages 2018
Positive allosteric modulation of M1 and M4 muscarinic receptors as potential therapeutic treatments for schizophrenia Fulltext Access 41 Pages 2018
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening Fulltext Access 41 Pages 2018
Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening Fulltext Access 41 Pages 2018
Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques Fulltext Access 41 Pages 2018
Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Fulltext Access 41 Pages 2018
Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time Fulltext Access 41 Pages 2018
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism Fulltext Access 41 Pages 2018
Low doses of prenatal ethanol exposure and maternal separation alter HPA axis function and ethanol consumption in adult male rats Fulltext Access 42 Pages 2018
Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats Fulltext Access 42 Pages 2018
Targeting the Dvl-1/β-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion Fulltext Access 42 Pages 2018
Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein Fulltext Access 42 Pages 2018
Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats Fulltext Access 42 Pages 2018
Kv3 K+ currents contribute to spike-timing in dorsal cochlear nucleus principal cells Fulltext Access 42 Pages 2018
Autoantibody-mediated diseases of the CNS: Structure, dysfunction and therapy Fulltext Access 42 Pages 2018
Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation Fulltext Access 42 Pages 2018
Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7 Fulltext Access 42 Pages 2018
JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid Fulltext Access 42 Pages 2018
Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment Fulltext Access 42 Pages 2018
A hypothalamo-midbrain-medullary pathway involved in the inhibition of the respiratory chemoreflex response induced by potassium cyanide in rodents Fulltext Access 42 Pages 2018
Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury Fulltext Access 42 Pages 2018
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A Fulltext Access 42 Pages 2018
Lixisenatide ameliorates cerebral ischemia-reperfusion injury via GLP-1 receptor dependent/independent pathways Fulltext Access 42 Pages 2018
Ras inhibitor S-trans, trans-farnesylthiosalicylic acid enhances spatial memory and hippocampal long-term potentiation via up-regulation of NMDA receptor Fulltext Access 42 Pages 2018
Using chemical bond-based method to predict site of metabolism for five biotransformations mediated by CYP 3A4, 2D6, and 2C9 Fulltext Access 42 Pages 2018