Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico Fulltext Access 39 Pages 2018
Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats Fulltext Access 39 Pages 2018
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Fulltext Access 39 Pages 2018
A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects Fulltext Access 39 Pages 2018
PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy Fulltext Access 39 Pages 2018
In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Î2-isoxazoline molecular skeleton Fulltext Access 39 Pages 2018
Distinctive binding properties of the negative allosteric modulator, [3H]SB269,652, at recombinant dopamine D3 receptors Fulltext Access 39 Pages 2018
SIRT5 and post-translational protein modifications: A potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism Fulltext Access 39 Pages 2018
Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1 Fulltext Access 39 Pages 2018
The modifying effect of kidney function on the association of cadmium exposure with blood pressure and cardiovascular mortality: NHANES 1999-2010 Fulltext Access 39 Pages 2018
99mTc-vinorelbine tartrate loaded spherulites: Lung disposition study in Sprague-Dawley rats by gamma scintigraphy Fulltext Access 39 Pages 2018
Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review Fulltext Access 39 Pages 2018
ErbB signaling antagonist ameliorates behavioral deficit induced by phencyclidine (PCP) in mice, without affecting metabolic syndrome markers Fulltext Access 39 Pages 2018
Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles Fulltext Access 39 Pages 2018
Aidi injection plus platinum-based chemotherapy for stage IIIB/IV non-small cell lung cancer: A meta-analysis of 42 RCTs following the PRISMA guidelines Fulltext Access 39 Pages 2018
Bu-Shen-Tong-Luo decoction prevents bone loss via inhibition of bone resorption and enhancement of angiogenesis in ovariectomy-induced osteoporosis of rats Fulltext Access 39 Pages 2018
Validation of ethnopharmacology of ayurvedic sarasvata ghrita and comparative evaluation of its neuroprotective effect with modern alcoholic and lipid based extracts in β-amyloid induced memory impairment Fulltext Access 39 Pages 2018
A supplementary functional connectivity microstate attached to the default mode network in depression revealed by resting-state magnetoencephalography Fulltext Access 39 Pages 2018
Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma Fulltext Access 39 Pages 2018
Potential cancer chemopreventive and anticancer constituents from the fruits of Ficus hispida L.f. (Moraceae) Fulltext Access 39 Pages 2018
Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models Fulltext Access 39 Pages 2018
Comprehensive behavioral analyses of anoctamin1/TMEM16A-conditional knockout mice Fulltext Access 39 Pages 2018
Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway Fulltext Access 39 Pages 2018
Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction Fulltext Access 39 Pages 2018
A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer Fulltext Access 39 Pages 2018
Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats Fulltext Access 39 Pages 2018
Pharmacological modulation of the CO2/HCO3â/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase Fulltext Access 39 Pages 2018
Methylated flavonoids as anti-seizure agents: Naringenin 4â²,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models Fulltext Access 39 Pages 2018
Evaluation of the influence of green extraction solvents on the cytotoxic activities of Crinum (Amaryllidaeae) alkaloid extracts using in-vitro-in-silico approach Fulltext Access 39 Pages 2018
Estimating the Physicochemical Properties of Polysubstituted Aromatic Compounds Using UPPER Fulltext Access 39 Pages 2018
Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases Fulltext Access 39 Pages 2018
Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder Fulltext Access 39 Pages 2018
Biochemical effects of commercial feedstuffs on the fry of climbing perch (Anabas testudineus) and its impact on Swiss albino mice as an animal model Fulltext Access 39 Pages 2018
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion Fulltext Access 39 Pages 2018
P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability Fulltext Access 39 Pages 2018
The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats Fulltext Access 39 Pages 2018
Suppression of Akt-mediated HDAC3 expression and CDK2 T39 phosphorylation by a bichalcone analog contributes to S phase retardation of cancer cells Fulltext Access 39 Pages 2018
Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor Fulltext Access 40 Pages 2018
Changes in behavioural parameters, oxidative stress and neurotrophins in the brain of adult offspring induced to an animal model of schizophrenia: The effects of FA deficient or FA supplemented diet during the neurodevelopmental phase Fulltext Access 40 Pages 2018
l-Arginine treatment improves angiogenic response and reduces matrix metalloproteinase activity in chronic heart failure patients with coronary artery disease Fulltext Access 40 Pages 2018
Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits Fulltext Access 40 Pages 2018
Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3 Fulltext Access 40 Pages 2018
Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice Fulltext Access 40 Pages 2018
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment Fulltext Access 40 Pages 2018
Regulation of obesity-associated metabolic disturbance by the antipsychotic drug olanzapine: Role of the autophagy-lysosome pathway Fulltext Access 40 Pages 2018
RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton Fulltext Access 40 Pages 2018
Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats Fulltext Access 40 Pages 2018
Paroxetine and rivastigmine mitigates adjuvant-induced rheumatoid arthritis in rats: Impact on oxidative stress, apoptosis and RANKL/OPG signals Fulltext Access 40 Pages 2018
The role of orphan G protein-coupled receptors in the modulation of pain: A review Fulltext Access 40 Pages 2018
Cannabidiol inhibits priming-induced reinstatement of methamphetamine in REM sleep deprived rats Fulltext Access 40 Pages 2018
α1A-Adrenoceptors, but not α1B- or α1D-adrenoceptors, contribute to enhanced contractile response to phenylephrine in cooling conditions in the rat tail artery Fulltext Access 40 Pages 2018
The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor Fulltext Access 40 Pages 2018
Zebrafish (Danio rerio) model as an early stage screening tool to study the biodistribution and toxicity profile of doxorubicin-loaded mixed micelles Fulltext Access 40 Pages 2018
3,4-Methylenedioxymethamphetamine, mephedrone, and β-phenylethylamine release dopamine from the cytoplasm by means of transporters and keep the concentration high and constant by blocking reuptake Fulltext Access 40 Pages 2018
UDP-sugars activate P2Y14 receptors to mediate vasoconstriction of the porcine coronary artery Fulltext Access 40 Pages 2018
Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells Fulltext Access 40 Pages 2018
Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells Fulltext Access 40 Pages 2018
Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus Fulltext Access 40 Pages 2018
Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice Fulltext Access 40 Pages 2018
Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis Fulltext Access 40 Pages 2018
Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva) Fulltext Access 40 Pages 2018
FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models Fulltext Access 40 Pages 2018
Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro Fulltext Access 40 Pages 2018
Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination Fulltext Access 40 Pages 2018
Baicalin modulates the Treg/Teff balance to alleviate uveitis by activating the aryl hydrocarbon receptor Fulltext Access 40 Pages 2018
Susceptibility of paramyxoviruses and filoviruses to inhibition by 2â²-monofluoro- and 2â²-difluoro-4â²-azidocytidine analogs Fulltext Access 40 Pages 2018
Favipiravir as a potential countermeasure against neglected and emerging RNA viruses Fulltext Access 40 Pages 2018
Evaluation of antiviral effects of novel NS5A inhibitors in hepatitis C virus cell culture system with full-genome infectious clones Fulltext Access 40 Pages 2018
Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee (Coffea robusta L.) bean extract Fulltext Access 40 Pages 2018
Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice Fulltext Access 40 Pages 2018
Application of TQSM polypharmacokinetics and its similarity approach to ascertain Q-marker by analyses of transitivity in vivo of five candidates in Buyanghuanwu injection Fulltext Access 40 Pages 2018
Bioactive compound 1,8-Cineole selectively induces G2/M arrest in A431 cells through the upregulation of the p53 signaling pathway and molecular docking studies Fulltext Access 40 Pages 2018
Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin Fulltext Access 40 Pages 2018
Ethnobotanical and ethnomedicinal studies in Baluchi tribes: A case study in Mt. Taftan, southeastern Iran Fulltext Access 40 Pages 2018
Mitochondrial control of store-operated Ca2+ channels in cancer: Pharmacological implications Fulltext Access 40 Pages 2018
The beclomethasone anti-inflammatory effect occurs in cell/mediator-dependent manner and is additively enhanced by formoterol: NFkB, p38, PKA analysis Fulltext Access 40 Pages 2018
Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways Fulltext Access 40 Pages 2018
Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-κB signaling Fulltext Access 40 Pages 2018
Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation Fulltext Access 40 Pages 2018
Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise Fulltext Access 40 Pages 2018
Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia Fulltext Access 40 Pages 2018
Antidiabetic effect of Achillea millefollium through multitarget interactions: α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities Fulltext Access 40 Pages 2018
Facilitating effects of Buyang Huanwu decoction on axonal regeneration after peripheral nerve transection Fulltext Access 40 Pages 2018
The anti-inflammatory peptide Ac-SDKP: Synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases Fulltext Access 40 Pages 2018
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors Fulltext Access 40 Pages 2018
Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation Fulltext Access 40 Pages 2018
Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir.: Chemical characterization, anti-nociceptive and anti-inflammatory activities of methanol extract of leaves Fulltext Access 40 Pages 2018
Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission Fulltext Access 40 Pages 2018
A novel selective MAO-B inhibitor with neuroprotective and anti-Parkinsonian properties Fulltext Access 40 Pages 2018
Downregulation of estrogen-related receptor alpha inhibits human cutaneous squamous cell carcinoma cell proliferation and migration by regulating EMT via fibronectin and STAT3 signaling pathways Fulltext Access 40 Pages 2018
Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel Fulltext Access 40 Pages 2018
2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils Fulltext Access 40 Pages 2018
Salidroside improves brain ischemic injury by activating PI3K/Akt pathway and reduces complications induced by delayed tPA treatment Fulltext Access 40 Pages 2018