Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery Fulltext Access 37 Pages 2018
Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine Fulltext Access 37 Pages 2018
Differential distribution and function of GABABRs in somato-dendritic and axonal compartments of principal cells and interneurons in cortical circuits Fulltext Access 37 Pages 2018
Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor Fulltext Access 37 Pages 2018
Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment Fulltext Access 37 Pages 2018
Anti-β2GPI/β2GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation Fulltext Access 37 Pages 2018
Chronic treatment with the new anticonvulsant drug lacosamide impairs learning and memory processes in rats: A possible role of BDNF/TrkB ligand receptor system Fulltext Access 37 Pages 2018
Medicinal foods and beverages among Maasai agro-pastoralists in northern Tanzania Fulltext Access 38 Pages 2018
A rich source of potential bioactive compounds with anticancer activities by Catharanthus roseus cambium meristematic stem cell cultures Fulltext Access 38 Pages 2018
The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells Fulltext Access 38 Pages 2018
The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions Fulltext Access 38 Pages 2018
Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2 Fulltext Access 38 Pages 2018
Gastroprotective effects of Hwanglyeonhaedok-tang against Helicobacter pylori-induced gastric cell injury Fulltext Access 38 Pages 2018
Resorcinolic lipid 3-heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one is a strategy for melanoma treatment Fulltext Access 38 Pages 2018
Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5 Fulltext Access 38 Pages 2018
Fasudil ameliorates the ischemia/reperfusion oxidative injury in rat hearts through suppression of myosin regulatory light chain/NADPH oxidase 2 pathway Fulltext Access 38 Pages 2018
BCL9 promotes epithelial mesenchymal transition and invasion in cisplatin resistant NSCLC cells via β-catenin pathway Fulltext Access 38 Pages 2018
Diverse signalling of the platelet P2Y1 receptor leads to a dichotomy in platelet function Fulltext Access 38 Pages 2018
Effects of AS2541019, a novel selective PI3Kδ inhibitor, on antibody production and hamster to rat xenotransplantation Fulltext Access 38 Pages 2018
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain Fulltext Access 38 Pages 2018
Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity Fulltext Access 38 Pages 2018
Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3γ Fulltext Access 38 Pages 2018
Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses Fulltext Access 38 Pages 2018
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo Fulltext Access 38 Pages 2018
Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation Fulltext Access 38 Pages 2018
Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction Fulltext Access 38 Pages 2018
E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice Fulltext Access 38 Pages 2018
Nasal immunization with RSV F and G protein fragments conjugated to an M cell-targeting ligand induces an enhanced immune response and protection against RSV infection Fulltext Access 38 Pages 2018
Upregulation of peripheral CXC and CC chemokine receptor expression on CD4+ T cells is associated with immune dysregulation in children with autism Fulltext Access 38 Pages 2018
The role of the endocannabinoid system in the antihyperalgesic effect of Cedrus atlantica essential oil inhalation in a mouse model of postoperative pain Fulltext Access 38 Pages 2018
PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection Fulltext Access 38 Pages 2018
Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1 Fulltext Access 38 Pages 2018
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage Fulltext Access 38 Pages 2018
An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes' extracts traditionally used in Rwanda for asthma treatment Fulltext Access 38 Pages 2018
The consequence of NAC on sodium arsenite-induced uterine oxidative stress Fulltext Access 38 Pages 2018
IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats Fulltext Access 38 Pages 2018
Cardiac safety evaluation in zebrafish and in silico ADME prediction of cephalosporins with an aminothiazoyl ring at the C-7 position Fulltext Access 38 Pages 2018
Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells Fulltext Access 38 Pages 2018
Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs Fulltext Access 38 Pages 2018
A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis Fulltext Access 38 Pages 2018
APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment Fulltext Access 38 Pages 2018
Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy Fulltext Access 38 Pages 2018
Imatinib prevents lung cancer metastasis by inhibiting M2-like polarization of macrophages Fulltext Access 38 Pages 2018
Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain Fulltext Access 38 Pages 2018
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT2R and Akt-dependent mechanism Fulltext Access 38 Pages 2018
Chemopreventive effects of FITOPROT against 5-fluorouracil-induced toxicity in HaCaT cells Fulltext Access 38 Pages 2018
Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin Fulltext Access 38 Pages 2018
Icariin doped bioactive glasses seeded with rat adipose-derived stem cells to promote bone repair via enhanced osteogenic and angiogenic activities Fulltext Access 38 Pages 2018
Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity Fulltext Access 38 Pages 2018
Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway Fulltext Access 38 Pages 2018
Quantitative expression and localization of GABAB receptor protein subunits in hippocampi from patients with refractory temporal lobe epilepsy Fulltext Access 38 Pages 2018
TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes Fulltext Access 38 Pages 2018
Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells Fulltext Access 38 Pages 2018
Quality specifications for articles of botanical origin from the United States Pharmacopeia Fulltext Access 38 Pages 2018
Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke Fulltext Access 38 Pages 2018
Short and long term modulation of tissue minerals concentrations following oral administration of black cumin (Nigella sativa L.) seed oil to laboratory rats Fulltext Access 38 Pages 2018
Could essential oils enhance biopolymers performance for wound healing? A systematic review Fulltext Access 38 Pages 2018
Biological activity and chemical profile of Lavatera thuringiaca L. extracts obtained by different extraction approaches Fulltext Access 38 Pages 2018
Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats Fulltext Access 38 Pages 2018
6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling Fulltext Access 38 Pages 2018
MPL and CpG combination adjuvants promote homologous and heterosubtypic cross protection of inactivated split influenza virus vaccine Fulltext Access 38 Pages 2018
Chinese herbal extract Su-duxing had potent inhibitory effects on both wild-type and entecavir-resistant hepatitis B virus (HBV) in vitro and effectively suppressed HBV replication in mouse model Fulltext Access 38 Pages 2018
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation Fulltext Access 38 Pages 2018
BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo Fulltext Access 38 Pages 2018
Novel secondary mutations C56S and G149A confer resistance to HIV-1 integrase strand transfer inhibitors Fulltext Access 38 Pages 2018
Identification of a peptide derived from the heptad repeat 2 region of the porcine epidemic diarrhea virus (PEDV) spike glycoprotein that is capable of suppressing PEDV entry and inducing neutralizing antibodies Fulltext Access 38 Pages 2018
An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs Fulltext Access 38 Pages 2018
A Biopredictive In Vitro Comparison of Oral Locally Acting Mesalazine Formulations by a Novel Dissolution Model for Assessing Intraluminal Drug Release in Individual Subjects Fulltext Access 38 Pages 2018
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes Fulltext Access 38 Pages 2018
Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn Fulltext Access 38 Pages 2018
Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro Fulltext Access 38 Pages 2018
Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice Fulltext Access 38 Pages 2018
Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice Fulltext Access 39 Pages 2018
Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants Fulltext Access 39 Pages 2018
Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues Fulltext Access 39 Pages 2018
Sesquiterpene lactones from Ambrosia arborescens Mill. inhibit pro-inflammatory cytokine expression and modulate NF-κB signaling in human skin cells Fulltext Access 39 Pages 2018
Activation of axon initial segmental GABAA receptors inhibits action potential generation in neocortical GABAergic interneurons Fulltext Access 39 Pages 2018
Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain Fulltext Access 39 Pages 2018
Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress Fulltext Access 39 Pages 2018
Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice Fulltext Access 39 Pages 2018
Basolateral amygdala noradrenergic activity is required for enhancement of object recognition memory by histone deacetylase inhibition in the anterior insular cortex Fulltext Access 39 Pages 2018
The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain Fulltext Access 39 Pages 2018
Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches Fulltext Access 39 Pages 2018
SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease Fulltext Access 39 Pages 2018
Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats Fulltext Access 39 Pages 2018
β-N-oxalyl-L-α,β-diaminopropionic acid induces wound healing by stabilizing HIF-1α and modulating associated protein expression Fulltext Access 39 Pages 2018
Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells Fulltext Access 39 Pages 2018
Self-efficacy for deprescribing: A survey for health care professionals using evidence-based deprescribing guidelines Fulltext Access 39 Pages 2018
TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligands Fulltext Access 39 Pages 2018
Susceptibility of Brazilian influenza A(H1N1)pdm09 viruses to neuraminidase inhibitors in the 2014-2016 seasons: Identification of strains bearing mutations associated with reduced inhibition profile Fulltext Access 39 Pages 2018
A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization Fulltext Access 39 Pages 2018
A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101 Fulltext Access 39 Pages 2018
Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice Fulltext Access 39 Pages 2018
Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility Fulltext Access 39 Pages 2018
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak Fulltext Access 39 Pages 2018
How often should we expect to be wrong? Statistical power, P values, and the expected prevalence of false discoveries Fulltext Access 39 Pages 2018
Metronomic vinorelbine is directly active on Non Small Cell Lung Cancer cells and sensitizes the EGFRL858R/T790M cells to reversible EGFR tyrosine kinase inhibitors Fulltext Access 39 Pages 2018