Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes Fulltext Access 35 Pages 2018
Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allemão - A conservationist proposal for the species Fulltext Access 35 Pages 2018
Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS Fulltext Access 35 Pages 2018
Lycium europaeum Linn as a source of polysaccharide with in vitro antioxidant activities and in vivo anti-inflammatory and hepato-nephroprotective potentials Fulltext Access 35 Pages 2018
β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway Fulltext Access 35 Pages 2018
PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention Fulltext Access 35 Pages 2018
Clonidine preconditioning improved cerebral ischemia-induced learning and memory deficits in rats via ERK1/2-CREB/ NF-κB-NR2B pathway Fulltext Access 35 Pages 2018
Abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, has a fast association rate and long residence time at receptor Fulltext Access 35 Pages 2018
Melatonin inhibits rotenone-induced SH-SY5Y cell death via the downregulation of Dynamin-Related Protein 1 expression Fulltext Access 35 Pages 2018
Ethnopharmacological properties of Artemisia asiatica: A comprehensive review Fulltext Access 35 Pages 2018
Blockage of endoplasmic reticulum stress attenuates nilotinib-induced cardiotoxicity by inhibition of the Akt-GSK3β-Nox4 signaling Fulltext Access 35 Pages 2018
DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease Fulltext Access 35 Pages 2018
3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats Fulltext Access 35 Pages 2018
Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway Fulltext Access 35 Pages 2018
Identification and functional characterization of zebrafish K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels Fulltext Access 35 Pages 2018
sst2-receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing Fulltext Access 35 Pages 2018
Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension Fulltext Access 35 Pages 2018
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling Fulltext Access 35 Pages 2018
Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect Fulltext Access 35 Pages 2018
Early child adversity and psychopathology in adulthood: HPA axis and cognitive dysregulations as potential mechanisms Fulltext Access 35 Pages 2018
Autophagy-mediated neuroprotection induced by octreotide in an ex vivo model of early diabetic retinopathy Fulltext Access 35 Pages 2018
Antibacterial activity and pharmacokinetic profile of a promising antibacterial agent: 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin Fulltext Access 35 Pages 2018
Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target Fulltext Access 35 Pages 2018
The effects of polysaccharides from Auricularia auricula (Huaier) in adjuvant anti-gastrointestinal cancer therapy: A systematic review and network meta-analysis Fulltext Access 35 Pages 2018
Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil Fulltext Access 35 Pages 2018
Acute and sub-acute oral toxicity studies of the aqueous extract from radix, radix with cortex and cortex of Psammosilene tunicoides in mice and rats Fulltext Access 35 Pages 2018
Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha Fulltext Access 35 Pages 2018
Vitamin D treatment abrogates the inflammatory response in paraquat-induced lung fibrosis Fulltext Access 35 Pages 2018
Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke Fulltext Access 35 Pages 2018
Protective effects of diketopiperazines from Moslae Herba against influenza A virus-induced pulmonary inflammation via inhibition of viral replication and platelets aggregation Fulltext Access 35 Pages 2018
A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model Fulltext Access 35 Pages 2018
Pharmacological effect of prohibited combination pair Panax ginseng and Veratrum nigrum on colorectal metastasis in vitro and in vivo Fulltext Access 35 Pages 2018
Bioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxication Fulltext Access 35 Pages 2018
Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage Fulltext Access 35 Pages 2018
Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet Fulltext Access 35 Pages 2018
Ethyl-acetate fraction of Trichilia catigua protects against oxidative stress and neuroinflammation after cerebral ischemia/reperfusion Fulltext Access 35 Pages 2018
Anti-angiogenic activity of para-coumaric acid methyl ester on HUVECs in vitro and zebrafish in vivo Fulltext Access 35 Pages 2018
LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells Fulltext Access 35 Pages 2018
Seabuckthorn berry polysaccharide extracts protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2/HO-1-SOD-2 signaling pathway Fulltext Access 35 Pages 2018
Effects of Xin-Ji-Er-Kang on heart failure induced by myocardial infarction: Role of inflammation, oxidative stress and endothelial dysfunction Fulltext Access 35 Pages 2018
Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice Fulltext Access 35 Pages 2018
The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells Fulltext Access 35 Pages 2018
Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells Fulltext Access 35 Pages 2018
Improvement of glucocorticoid-impaired thymus function by dihydromyricetin via up-regulation of PPARγ-associated fatty acid metabolism Fulltext Access 35 Pages 2018
Role of the serotonergic pathway in uterotonic activity of Ananas comosus (L.) Merr. - An in vitro and in vivo study Fulltext Access 35 Pages 2018
Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses Fulltext Access 35 Pages 2018
Barbiturates enhance itch-associated scratching in atopic dermatitis mice: A possible clue to understanding nocturnal pruritus in atopic dermatitis Fulltext Access 35 Pages 2018
Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice Fulltext Access 35 Pages 2018
Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblast Fulltext Access 35 Pages 2018
Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models Fulltext Access 35 Pages 2018
Stimulation of accumbal GABAB receptors inhibits delta1- and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats Fulltext Access 35 Pages 2018
Reduced cortical serotonin 5-HT2A receptor binding and glutamate activity in high compulsive drinker rats Fulltext Access 35 Pages 2018
Euphorbia factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation in mice through the suppression of NF-κB activation Fulltext Access 35 Pages 2018
Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells Fulltext Access 35 Pages 2018
Antitumor effects of seleno-β-lactoglobulin (Se-β-Lg) against human gastric cancer MGC-803 cells Fulltext Access 35 Pages 2018
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes Fulltext Access 35 Pages 2018
Rutin restricts hydrogen peroxide-induced alterations by up-regulating the redox-system: An in vitro, in vivo and in silico study Fulltext Access 35 Pages 2018
A fungal metabolite zearalenone as a CFTR inhibitor and potential therapy of secretory diarrheas Fulltext Access 35 Pages 2018
Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline Fulltext Access 35 Pages 2018
Angiotensin II facilitates neointimal formation by increasing vascular smooth muscle cell migration: Involvement of APE/Ref-1-mediated overexpression of sphingosine-1-phosphate receptor 1 Fulltext Access 35 Pages 2018
Syringic acid prevents skin carcinogenesis via regulation of NoX and EGFR signaling Fulltext Access 35 Pages 2018
Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer Fulltext Access 35 Pages 2018
Fullerene (C60) particle size implications in neurotoxicity following infusion into the hippocampi of Wistar rats Fulltext Access 35 Pages 2018
Retinoic acid receptor β, a potential therapeutic target in the inhibition of adenovirus replication Fulltext Access 35 Pages 2018
Antioxidant N-acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats Fulltext Access 35 Pages 2018
A tetravalent vaccine comprising hexon-chimeric adenoviruses elicits balanced protective immunity against human adenovirus types 3, 7, 14 and 55 Fulltext Access 35 Pages 2018
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP) Fulltext Access 35 Pages 2018
Toxic activity and protein identification from the parotoid gland secretion of the common toad Bufo bufo Fulltext Access 36 Pages 2018
Neural correlates of working memory in first episode and recurrent depression: An fMRI study Fulltext Access 36 Pages 2018
The genus Ficus (Moraceae) used in diet: Its plant diversity, distribution, traditional uses and ethnopharmacological importance Fulltext Access 36 Pages 2018
Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis Fulltext Access 36 Pages 2018
Cinnamaldehyde protects VSMCs against ox-LDL-induced proliferation and migration through S arrest and inhibition of p38, JNK/MAPKs and NF-κB Fulltext Access 36 Pages 2018
The genetic adjuvant IL-12 enhances the protective efficacy of a DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular injection in mice Fulltext Access 36 Pages 2018
Ethanolic extract of the aerial parts of Passiflora cincinnata Mast. (Passifloraceae) reduces nociceptive and inflammatory events in mice Fulltext Access 36 Pages 2018
Apremilast prevent doxorubicin-induced apoptosis and inflammation in heart through inhibition of oxidative stress mediated activation of NF-κB signaling pathways Fulltext Access 36 Pages 2018
Murine genetic variance in muscarinic cholinergic receptor antagonism of acquisition and expression of sucrose-conditioned flavor preferences in three inbred mouse strains Fulltext Access 36 Pages 2018
Calcium uptake and cytochrome c release from normal and ischemic brain mitochondria Fulltext Access 36 Pages 2018
Application of the gene editing tool, CRISPR-Cas9, for treating neurodegenerative diseases Fulltext Access 36 Pages 2018
4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways Fulltext Access 36 Pages 2018
In situ monitoring of the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET Fulltext Access 36 Pages 2018
Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody Fulltext Access 36 Pages 2018
Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation Fulltext Access 36 Pages 2018
CNS distribution, signalling properties and central effects of G-protein coupled receptor 4 Fulltext Access 36 Pages 2018
Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment Fulltext Access 36 Pages 2018
Chronic morphine selectively sensitizes the effect of D1 receptor agonist on presynaptic glutamate release in basolateral amygdala neurons that project to prelimbic cortex Fulltext Access 36 Pages 2018
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock Fulltext Access 36 Pages 2018
Nigella sativa fixed oil as alternative treatment in management of pain in arthritis rheumatoid Fulltext Access 36 Pages 2018
The effects of wild bitter gourd fruit extracts on ICAM-1 expression in pulmonary epithelial cells of C57BL/6J mice and microRNA-221/222 knockout mice: Involvement of the miR-221/-222/PI3K/AKT/NF-κB pathway Fulltext Access 36 Pages 2018
Insect cell-produced recombinant protein subunit vaccines protect against Zika virus infection Fulltext Access 36 Pages 2018
Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses Fulltext Access 36 Pages 2018
Protostemonine attenuates alternatively activated macrophage and DRA-induced asthmatic inflammation Fulltext Access 36 Pages 2018
A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo Fulltext Access 36 Pages 2018
Vaspin protects rats against myocardial ischemia/reperfusion injury (MIRI) through the TLR4/NF-κB signaling pathway Fulltext Access 36 Pages 2018
Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3 Fulltext Access 36 Pages 2018
Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats Fulltext Access 36 Pages 2018
An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7 Fulltext Access 36 Pages 2018
Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT Fulltext Access 36 Pages 2018