BQ123 selectively improved tumor perfusion and enhanced nanomedicine delivery for glioblastomas treatment Fulltext Access 33 Pages 2018
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Fulltext Access 33 Pages 2018
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics Fulltext Access 33 Pages 2018
Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53 Fulltext Access 33 Pages 2018
Paljung-San, a traditional herbal medicine, attenuates benign prostatic hyperplasia in vitro and in vivo Fulltext Access 34 Pages 2018
uPA/uPAR signaling in rheumatoid arthritis: Shedding light on its mechanism of action Fulltext Access 34 Pages 2018
MicroRNA-485-5p suppresses growth and metastasis in non-small cell lung cancer cells by targeting IGF2BP2 Fulltext Access 34 Pages 2018
N-(3-oxododecanoyl)-l-homoserine lactone modulates mitochondrial function and suppresses proliferation in intestinal goblet cells Fulltext Access 34 Pages 2018
miRNA-150-5p associate with antihypertensive effect of epigallocatechin-3-gallate revealed by aorta miRNome analysis of spontaneously hypertensive rat Fulltext Access 34 Pages 2018
Neurobehavioral and biochemical modulation following administration of MgO and ZnO nanoparticles in the presence and absence of acute stress Fulltext Access 34 Pages 2018
Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway Fulltext Access 34 Pages 2018
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats Fulltext Access 34 Pages 2018
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide Fulltext Access 34 Pages 2018
Role of p-MKK7 in myricetin-induced protection against intestinal ischemia/reperfusion injury Fulltext Access 34 Pages 2018
Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection Fulltext Access 34 Pages 2018
Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells Fulltext Access 34 Pages 2018
Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish Fulltext Access 34 Pages 2018
Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibiting TNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells Fulltext Access 34 Pages 2018
Effects of anthraquinones from Cassia occidentalis L. on ovalbumin-induced airways inflammation in a mouse model of allergic asthma Fulltext Access 34 Pages 2018
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7 Fulltext Access 34 Pages 2018
Quality control of goji (fruits of Lycium barbarum L. and L. chinense Mill.): A value chain analysis perspective Fulltext Access 34 Pages 2018
Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr Fulltext Access 34 Pages 2018
Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction Fulltext Access 34 Pages 2018
Blockade of NMDA receptors blocks the acquisition of cocaine conditioned approach in rats Fulltext Access 34 Pages 2018
β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice Fulltext Access 34 Pages 2018
Atomoxetine prevents working memory loss in hyperactive rats, mediating plastic changes in prefrontal cortex pyramidal neurons Fulltext Access 34 Pages 2018
Ginger (Zingiber officinale): An alternative for the prevention of postoperative nausea and vomiting. A meta-analysis Fulltext Access 34 Pages 2018
Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum Fulltext Access 34 Pages 2018
3D tissue engineering, an emerging technique for pharmaceutical research Fulltext Access 34 Pages 2018
Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells Fulltext Access 34 Pages 2018
Novel nor-monoterpenoid indole alkaloids inhibiting glioma stem cells from fruits of Alstonia scholaris Fulltext Access 34 Pages 2018
Immunization with Na+/K+ ATPase DR peptide prevents bone loss in an ovariectomized rat osteoporosis model Fulltext Access 34 Pages 2018
Attenuation of high glucose induced apoptotic and inflammatory signaling pathways in RIN-m5F pancreatic β cell lines by Hibiscus rosa sinensis L. petals and its phytoconstituents Fulltext Access 34 Pages 2018
Oxytocin release via activation of TRPM2 and CD38 in the hypothalamus during hyperthermia in mice: Implication for autism spectrum disorder Fulltext Access 34 Pages 2018
Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157 Fulltext Access 34 Pages 2018
Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway Fulltext Access 34 Pages 2018
Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways Fulltext Access 34 Pages 2018
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats Fulltext Access 34 Pages 2018
Neural indices of emotional reactivity and regulation predict course of PTSD symptoms in combat-exposed veterans Fulltext Access 34 Pages 2018
Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder Fulltext Access 34 Pages 2018
Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD Fulltext Access 34 Pages 2018
Reflection on the selection of doses of arenobufagin in vivo anticancer study Fulltext Access 34 Pages 2018
Interactions between microRNAs and long non-coding RNAs in cardiac development and repair Fulltext Access 34 Pages 2018
The fruits of Gleditsia sinensis Lam. inhibits adipogenesis through modulation of mitotic clonal expansion and STAT3 activation in 3T3-L1 cells Fulltext Access 34 Pages 2018
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell Fulltext Access 34 Pages 2018
Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease Fulltext Access 34 Pages 2018
GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways Fulltext Access 34 Pages 2018
Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice Fulltext Access 34 Pages 2018
Sofosbuvir inhibits hepatitis A virus replication in vitro assessed by a cell-based fluorescent reporter system Fulltext Access 34 Pages 2018
Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein Fulltext Access 34 Pages 2018
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway Fulltext Access 34 Pages 2018
Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells Fulltext Access 34 Pages 2018
Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation Fulltext Access 34 Pages 2018
Luteolin-4â²-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models Fulltext Access 34 Pages 2018
Acute effects of vortioxetine and duloxetine on resting-state functional connectivity in the awake rat Fulltext Access 34 Pages 2018
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses Fulltext Access 34 Pages 2018
Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement Fulltext Access 34 Pages 2018
Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex Fulltext Access 34 Pages 2018
Regulation of P2X7 receptor function of neural progenitor cells in the hippocampal subgranular zone by neuronal activity in the dentate gyrus Fulltext Access 34 Pages 2018
Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility Fulltext Access 34 Pages 2018
Japan-Specific Key Regulatory Aspects for Development of New Biopharmaceutical Drug Products Fulltext Access 34 Pages 2018
Hydrogen sulfide attenuates homocysteine-induced neurotoxicity by preventing mitochondrial dysfunctions and oxidative damage: In vitro and in vivo studies Fulltext Access 34 Pages 2018
In vitro antiglycating effect and in vivo neuroprotective activity of Trigonelline in d-galactose induced cognitive impairment Fulltext Access 34 Pages 2018
Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β1-induced HSCs activation pathway Fulltext Access 34 Pages 2018
Selective downregulation of vesicular glutamate transporter2 in ventral posterolateral nucleus of thalamus attenuates neuropathic mechanical allodynia in mice Fulltext Access 34 Pages 2018
PAC-1 and its derivative WF-210 Inhibit Angiogenesis by inhibiting VEGF/VEGFR pathway Fulltext Access 34 Pages 2018
Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine Fulltext Access 34 Pages 2018
Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway Fulltext Access 34 Pages 2018
Chronic ethanol consumption increases vascular oxidative stress and the mortality induced by sub-lethal sepsis: Potential role of iNOS Fulltext Access 34 Pages 2018
The Role of Mitochondria in Methamphetamine-induced inhibitory effects on osteogenesis of Mesenchymal Stem Cells Fulltext Access 34 Pages 2018
GABA dramatically improves glucose tolerance in streptozotocin-induced diabetic rats fed with high-fat diet Fulltext Access 34 Pages 2018
Protective effects of α-mangostin against acetaminophen-induced acute liver injury in mice Fulltext Access 34 Pages 2018
A novel PPARα/γ agonist, propane-2-sulfonic acid octadec-9-enyl-amide, ameliorates insulin resistance and gluconeogenesis in vivo and vitro Fulltext Access 34 Pages 2018
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway Fulltext Access 34 Pages 2018
Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice Fulltext Access 34 Pages 2018
Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models Fulltext Access 34 Pages 2018
The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms Fulltext Access 34 Pages 2018
Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator Fulltext Access 34 Pages 2018
GSH depletion, mitochondrial membrane breakdown, caspase-3/7 activation and DNA fragmentation in U87MG glioblastoma cells: New insight into the mechanism of cytotoxicity induced by fluoroquinolones Fulltext Access 34 Pages 2018
Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis Fulltext Access 34 Pages 2018
Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in Dystonia musculorum mice Fulltext Access 35 Pages 2018
Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR. Influence of beta-adrenergic blockade Fulltext Access 35 Pages 2018
Gestational 3,3â²,4,4â²,5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction Fulltext Access 35 Pages 2018
Gambogic acid ameliorates diabetes-induced proliferative retinopathy through inhibition of the HIF-1α/VEGF expression via targeting PI3K/AKT pathway Fulltext Access 35 Pages 2018
Protective effect of S-nitrosoglutathione administration against hyperglycemia induced disruption of blood brain barrier is mediated by modulation of tight junction proteins and cell adhesion molecules Fulltext Access 35 Pages 2018
C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities Fulltext Access 35 Pages 2018
Oxycodone self-administration during pregnancy disrupts the maternal-infant dyad and decreases midbrain OPRM1 expression during early postnatal development in rats Fulltext Access 35 Pages 2018
Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition Fulltext Access 35 Pages 2018
Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins Fulltext Access 35 Pages 2018
Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story Fulltext Access 35 Pages 2018
PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases Fulltext Access 35 Pages 2018
Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway Fulltext Access 35 Pages 2018
Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage Fulltext Access 35 Pages 2018
Nandrolone alter left ventricular contractility and promotes remodelling involving calcium-handling proteins and renin-angiotensin system in male SHR Fulltext Access 35 Pages 2018
The regulation of ginsenoside Rg1 upon aging of bone marrow stromal cell contribute to delaying senescence of bone marrow mononuclear cells (BMNCs) Fulltext Access 35 Pages 2018
Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats Fulltext Access 35 Pages 2018
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154 Fulltext Access 35 Pages 2018