Bio-guided fractionation and isolation of active component from Tragopogon graminifolius based on its wound healing property Fulltext Access 31 Pages 2018
Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice Fulltext Access 31 Pages 2018
Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells Fulltext Access 31 Pages 2018
Eisenia bicyclis (brown alga) modulates platelet function and inhibits thrombus formation via impaired P2Y12 receptor signaling pathway Fulltext Access 31 Pages 2018
The “Interval Walking in Colorectal Cancer” (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial Fulltext Access 31 Pages 2018
A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3 Fulltext Access 31 Pages 2018
Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication Fulltext Access 31 Pages 2018
The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling Fulltext Access 31 Pages 2018
A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications Fulltext Access 31 Pages 2018
Decarboxylation of Ang-(1-7) to Ala1-Ang-(1-7) leads to significant changes in pharmacodynamics Fulltext Access 31 Pages 2018
κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation Fulltext Access 31 Pages 2018
Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice Fulltext Access 31 Pages 2018
Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review Fulltext Access 31 Pages 2018
Wenyang Huoxue Jiedu formula inhibits thin-cap fibroatheroma plaque formation via the VEGF/VEGFR signaling pathway Fulltext Access 31 Pages 2018
Survey on medicinal plants traditionally used in Senegal for the treatment of tuberculosis (TB) and assessment of their antimycobacterial activity Fulltext Access 31 Pages 2018
Effect of Eucommia ulmoides Oliv., Gynostemma pentaphyllum (Thunb.) Makino, and Curcuma longa L. on Th1- and Th2-cytokine responses and human leukocyte antigen-DR expression in peripheral blood mononuclear cells of septic patients Fulltext Access 31 Pages 2018
Sessein and isosessein with anti-inflammatory, antibacterial and antioxidant activity isolated from Salvia sessei Benth Fulltext Access 31 Pages 2018
Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis Fulltext Access 31 Pages 2018
Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine Fulltext Access 31 Pages 2018
Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states Fulltext Access 31 Pages 2018
Implementation of fluorescence anisotropy-based assay for the characterization of ligand binding to dopamine D1 receptors Fulltext Access 31 Pages 2018
miR-381 induces sensitivity of breast cancer cells to doxorubicin by inactivation of MAPK signaling via FYN Fulltext Access 31 Pages 2018
Effect of acetaminophen on osteoblastic differentiation and migration of MC3T3-E1 cells Fulltext Access 31 Pages 2018
Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System From Bacillus anthracis Fulltext Access 31 Pages 2018
Dehydroascorbic Acid and pGPMA Dual Modified pH-Sensitive Polymeric Micelles for Target Treatment of Liver Cancer Fulltext Access 31 Pages 2018
Changes in the concentrations of inflammatory and oxidative status biomediators (MIP-1 α, PMN elastase, MDA, and IL-12) in depressed patients with and without posttraumatic stress disorder Fulltext Access 31 Pages 2018
Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster Fulltext Access 31 Pages 2018
GLP-1 signaling and alcohol-mediated behaviors; preclinical and clinical evidence Fulltext Access 31 Pages 2018
Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model Fulltext Access 31 Pages 2018
The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats Fulltext Access 31 Pages 2018
Regulation of the ARE-binding proteins, TTP (tristetraprolin) and HuR (human antigen R), in inflammatory response in astrocytes Fulltext Access 31 Pages 2018
Bioadhesive Chitosan-Coated Cationic Nanoliposomes With Improved Insulin Encapsulation and Prolonged Oral Hypoglycemic Effect in Diabetic Mice Fulltext Access 31 Pages 2018
An Unexpected Degradation Pathway of a 1,2,4-Triazolo[4,3-a]pyridine Derivative: The Formation of 2 Cationic Pseudodimers of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Drug Candidate in a Stressed Capsule Formulation Fulltext Access 31 Pages 2018
Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease Fulltext Access 31 Pages 2018
Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease Fulltext Access 31 Pages 2018
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility Fulltext Access 32 Pages 2018
Family environment interacts with CRHR1 rs17689918 to predict mental health and behavioral outcomes Fulltext Access 32 Pages 2018
Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial Fulltext Access 32 Pages 2018
Interactive effects of morphine and nicotine on memory function depend on the central amygdala cannabinoid CB1 receptor function in rats Fulltext Access 32 Pages 2018
Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine Fulltext Access 32 Pages 2018
The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats Fulltext Access 32 Pages 2018
The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis Fulltext Access 32 Pages 2018
Cysteinyl-leukotriene pathway as a new therapeutic target for the treatment of atherosclerosis related to obstructive sleep apnea syndrome Fulltext Access 32 Pages 2018
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Fulltext Access 32 Pages 2018
Centchroman regulates breast cancer angiogenesis via inhibition of HIF-1α/VEGFR2 signalling axis Fulltext Access 32 Pages 2018
Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity Fulltext Access 32 Pages 2018
Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis via IL-6/JAK2/STAT3 signaling blockade as evidenced through data-based mathematical modeling Fulltext Access 32 Pages 2018
Continuous application of compressive force induces fusion of osteoclast-like RAW264.7 cells via upregulation of RANK and downregulation of LGR4 Fulltext Access 32 Pages 2018
Intracerebroventricular microinjection of the 5-HT1F receptor agonist LY 344864 inhibits methamphetamine conditioned place preference reinstatement in rats Fulltext Access 32 Pages 2018
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy Fulltext Access 32 Pages 2018
P-gp is involved in the intestinal absorption and biliary excretion of afatinib in vitro and in rats Fulltext Access 32 Pages 2018
Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water Fulltext Access 32 Pages 2018
TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens Fulltext Access 32 Pages 2018
Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner Fulltext Access 32 Pages 2018
Met-enkephalin improves metabolic syndrome in high fat diet challenged mice through promotion of adipose tissue browning Fulltext Access 32 Pages 2018
Lipopolysaccharide from Porphyromonas gingivalis promotes autophagy of human gingival fibroblasts through the PI3K/Akt/mTOR signaling pathway Fulltext Access 32 Pages 2018
Conditioned disgust in rats (anticipatory nausea) to a context paired with the effects of the toxin LiCl: Influence of sex and the estrous cycle Fulltext Access 32 Pages 2018
Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study Fulltext Access 32 Pages 2018
The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome Fulltext Access 32 Pages 2018
Phenelzine, a cell adhesion molecule L1 mimetic small organic compound, promotes functional recovery and axonal regrowth in spinal cord-injured zebrafish Fulltext Access 32 Pages 2018
Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells Fulltext Access 32 Pages 2018
Deoxycholylglycine, a conjugated secondary bile acid, reduces vascular tone by attenuating Ca2+ sensitivity via rho kinase pathway Fulltext Access 32 Pages 2018
Toxicokinetics and tolerance of a high energy material 3,4,5-trinitropyrazole (TNP) in mice Fulltext Access 32 Pages 2018
Ability of using different dry powder inhalers during COPD exacerbations Fulltext Access 32 Pages 2018
Effect of sirolimus on liver cirrhosis and hepatic encephalopathy of common bile duct-ligated rats Fulltext Access 32 Pages 2018
Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues Fulltext Access 32 Pages 2018
Lateral septum stimulation disinhibits dopaminergic neurons in the antero-ventral region of the ventral tegmental area: Role of GABA-A alpha 1 receptors Fulltext Access 32 Pages 2018
Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring Fulltext Access 32 Pages 2018
Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling Fulltext Access 32 Pages 2018
Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats Fulltext Access 32 Pages 2018
Study on spectrum-effect correlation for screening the effective components in Fangji Huangqi Tang basing on ultra-high performance liquid chromatography-mass spectrometry Fulltext Access 32 Pages 2018
Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons Fulltext Access 32 Pages 2018
Methylene blue activates the PMCA activity and cross-interacts with amyloid β-peptide, blocking Aβ-mediated PMCA inhibition Fulltext Access 32 Pages 2018
Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays Fulltext Access 32 Pages 2018
Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia Fulltext Access 32 Pages 2018
Remifentanil preconditioning confers cardioprotection via c-Jun NH2-terminal kinases and extracellular signal regulated kinases pathways in ex-vivo failing rat heart Fulltext Access 32 Pages 2018
Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay Fulltext Access 32 Pages 2018
6,7,4â²-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice Fulltext Access 32 Pages 2018
Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model Fulltext Access 32 Pages 2018
Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT Fulltext Access 32 Pages 2018
Anti-IL-23 receptor monoclonal antibody prevents CD4+ T cell-mediated colitis in association with decreased systemic Th1 and Th17 responses Fulltext Access 32 Pages 2018
Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway Fulltext Access 32 Pages 2018
Pharmacological modulation of AMPA receptor phosphorylation by dopamine and muscarinic receptor agents in the rat medial prefrontal cortex Fulltext Access 32 Pages 2018
Assessments of cellular melatonin receptor signaling pathways: β-arrestin recruitment, receptor internalization, and impedance variations Fulltext Access 32 Pages 2018
FT-NIR characterization with chemometric analyses to differentiate goldenseal from common adulterants Fulltext Access 32 Pages 2018
Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway Fulltext Access 32 Pages 2018
Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats Fulltext Access 32 Pages 2018
Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1β, IL-6, TNF-α, NF-kB and upregulating IL-4 and IL-10 Fulltext Access 32 Pages 2018
Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration? Fulltext Access 32 Pages 2018
JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus Fulltext Access 32 Pages 2018
Interactions between crude drug extracts used in Japanese traditional Kampo medicines and organic anion-transporting polypeptide 2B1 Fulltext Access 32 Pages 2018
Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways Fulltext Access 32 Pages 2018
Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion Fulltext Access 32 Pages 2018
CRIP1 promotes cell migration, invasion and epithelial-mesenchymal transition of cervical cancer by activating the Wnt/βâcatenin signaling pathway Fulltext Access 32 Pages 2018