The role of miR-328 in high glucose-induced endothelial-to-mesenchymal transition in human umbilical vein endothelial cells Fulltext Access 29 Pages 2018
Identification of low molecular weight antimicrobial peptides from Iraqi camel milk fermented with Lactobacillus plantarum Fulltext Access 29 Pages 2018
Direct antiviral agents (DAAs) - A new age in the treatment of hepatitis C virus infection Fulltext Access 29 Pages 2018
Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine Fulltext Access 29 Pages 2018
Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial Fulltext Access 29 Pages 2018
Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells Fulltext Access 29 Pages 2018
Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress Fulltext Access 29 Pages 2018
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke Fulltext Access 29 Pages 2018
The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex Fulltext Access 29 Pages 2018
High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism Fulltext Access 29 Pages 2018
4-Fluorobenzaldehyde limonene-based thiosemicarbazone induces apoptosis in PC-3 human prostate cancer cells Fulltext Access 29 Pages 2018
mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine Fulltext Access 29 Pages 2018
Regulation of blood pressure is influenced by gender: A study in obese Zucker rats Fulltext Access 29 Pages 2018
Cardioprotective effect of Asphodelus tenuifolius Cav. on blood pressure and metabolic alterations in glucose-induced metabolic syndrome rats-An ethnopharmacological approach Fulltext Access 29 Pages 2018
Gancao-Gansui combination impacts gut microbiota diversity and related metabolic functions Fulltext Access 29 Pages 2018
Lipid-lowering and antiatherogenic effects of Vitex megapotamica (Spreng.) Moldenke in a mice experimental model Fulltext Access 29 Pages 2018
Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells Fulltext Access 29 Pages 2018
The pharmacological properties of Ophiocordyceps xuefengensis revealed by transcriptome analysis Fulltext Access 29 Pages 2018
Hepatoprotective effect of Forsythiae Fructus water extract against carbon tetrachloride-induced liver fibrosis in mice Fulltext Access 29 Pages 2018
Comparative pharmacokinetics of six coumarins in normal and breast cancer bone-metastatic mice after oral administration of Wenshen Zhuanggu Formula Fulltext Access 29 Pages 2018
Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways Fulltext Access 29 Pages 2018
Dilodendron bipinnatum Radlk. ameliorates airway inflammation through multiple targets in a murine model of ovalbumin-induced allergic airway disease Fulltext Access 29 Pages 2018
Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress Fulltext Access 29 Pages 2018
Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries Fulltext Access 29 Pages 2018
Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases Fulltext Access 29 Pages 2018
A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses Fulltext Access 29 Pages 2018
Green synthesis of labeled CeO2 nanoparticles with 99mTc and its biodistribution evaluation in mice Fulltext Access 29 Pages 2018
GAS5 promotes airway smooth muscle cell proliferation in asthma via controlling miR-10a/BDNF signaling pathway Fulltext Access 29 Pages 2018
Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21 Fulltext Access 29 Pages 2018
TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation Fulltext Access 29 Pages 2018
IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways Fulltext Access 29 Pages 2018
Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference Fulltext Access 29 Pages 2018
Sitagliptin attenuates intestinal ischemia/reperfusion injury via cAMP/PKA, PI3K/Akt pathway in a glucagon-like peptide 1 receptor-dependent manner Fulltext Access 29 Pages 2018
Beneficial effects of phycobiliproteins from Spirulina maxima in a preeclampsia model Fulltext Access 29 Pages 2018
Spondias tuberosa inner bark extract exert antidiabetic effects in streptozotocin-induced diabetic rats Fulltext Access 29 Pages 2018
Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L Fulltext Access 29 Pages 2018
Modulation of cellular bioenergetics by CO-releasing molecules and NO-donors inhibits the interaction of cancer cells with human lung microvascular endothelial cells Fulltext Access 29 Pages 2018
Inhibitory effects of extracellular superoxide dismutase on ultraviolet B-induced melanogenesis in murine skin and melanocytes Fulltext Access 29 Pages 2018
Structured pharmacist-led intervention programme to improve medication adherence in COPD patients: A randomized controlled study Fulltext Access 29 Pages 2018
The TEACH trial: Tailored education to assist label comprehension and health literacy Fulltext Access 29 Pages 2018
Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling Fulltext Access 29 Pages 2018
A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats Fulltext Access 29 Pages 2018
Thiopurine-induced toxicity is associated with dysfunction variant of the human molybdenum cofactor sulfurase gene (xanthinuria type II) Fulltext Access 29 Pages 2018
Abnormal long- and short-range functional connectivity in adolescent-onset schizophrenia patients: A resting-state fMRI study Fulltext Access 29 Pages 2018
Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways Fulltext Access 29 Pages 2018
Prior stress promotes the generalization of contextual fear memories: Involvement of the gabaergic signaling within the basolateral amygdala complex Fulltext Access 29 Pages 2018
Lost in translation: What's in an EC50? Innovative PK/PD reasoning in the drug development context Fulltext Access 29 Pages 2018
Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice Fulltext Access 29 Pages 2018
Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners Fulltext Access 29 Pages 2018
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro Fulltext Access 29 Pages 2018
Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice Fulltext Access 29 Pages 2018
Small molecules bind human mTOR protein and inhibit mTORC1 specifically Fulltext Access 29 Pages 2018
A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity Fulltext Access 29 Pages 2018
Synergism between the tyrosine kinase inhibitor sunitinib and Anti-TNF antibody protects against lethal dengue infection Fulltext Access 29 Pages 2018
The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers Fulltext Access 29 Pages 2018
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives Fulltext Access 29 Pages 2018
Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation Fulltext Access 29 Pages 2018
An integrated strategy for rapid discovery and identification of quality markers in Guanxin Kangtai preparation using UHPLC-TOF/MS and multivariate statistical analysis Fulltext Access 29 Pages 2018
Paeonol regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling Fulltext Access 29 Pages 2018
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes Fulltext Access 29 Pages 2018
Morroniside prevents H2O2 or Aβ1-42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation Fulltext Access 29 Pages 2018
Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node Fulltext Access 29 Pages 2018
Effect of co-administration of two different phosphodiesterase inhibitors and a β3-adrenoceptor agonist in an experimental model of detrusor overactivity Fulltext Access 29 Pages 2018
Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms Fulltext Access 29 Pages 2018
Unusual modes of action of the repellent DEET in insects highlight some human side effects Fulltext Access 29 Pages 2018
Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia Fulltext Access 29 Pages 2018
CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia Fulltext Access 29 Pages 2018
Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart Fulltext Access 29 Pages 2018
Targeting of EGFR increase anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform Fulltext Access 29 Pages 2018
Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response Fulltext Access 30 Pages 2018
The Preparation and Physicochemical Characterization of Aluminum Hydroxide/TLR7a, a Novel Vaccine Adjuvant Comprising a Small Molecule Adsorbed to Aluminum Hydroxide Fulltext Access 30 Pages 2018
Prolonged therapy with antidepressants increases hippocampal level of kynurenic acid and expression of Kat1 and Kat2 genes Fulltext Access 30 Pages 2018
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride Fulltext Access 30 Pages 2018
Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway Fulltext Access 30 Pages 2018
Basic fibroblast growth factor increased glucocorticoid receptors in cortical neurons through MAP kinase pathway Fulltext Access 30 Pages 2018
C-terminal degradation of PYY peptides in plasma abolishes effects on satiety and beta-cell function Fulltext Access 30 Pages 2018
Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan Fulltext Access 30 Pages 2018
Male rats with same-sex preference show higher immobility in the forced swim test, but similar effects of fluoxetine and desipramine than males that prefer females Fulltext Access 30 Pages 2018
Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells Fulltext Access 30 Pages 2018
Impact of immune suppressive agents on the BK-Polyomavirus non coding control region Fulltext Access 30 Pages 2018
Hemin blunts the depressant effect of chronic nicotine on reflex tachycardia via activation of central NOS/PI3K pathway in female rats Fulltext Access 30 Pages 2018
Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1 Fulltext Access 30 Pages 2018
In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis Fulltext Access 30 Pages 2018
Nuciferine and paeoniflorin can be quality markers of Tangzhiqing tablet, a Chinese traditional patent medicine, based on the qualitative, quantitative and dose-exposure-response analysis Fulltext Access 30 Pages 2018
Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells Fulltext Access 30 Pages 2018
Immunomodulatory, hemolytic and cytotoxic activity potentials of triterpenoid saponins from eight Cephalaria species Fulltext Access 30 Pages 2018
Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses Fulltext Access 30 Pages 2018
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis Fulltext Access 30 Pages 2018
SR-A1 suppresses colon inflammation and tumorigenesis through negative regulation of NF-κB signaling Fulltext Access 30 Pages 2018
Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn(PipNONO)Cl Fulltext Access 30 Pages 2018
Activation of soluble guanylyl cyclase with inhibition of multidrug resistance protein inhibitor-4 (MRP4) as a new antiplatelet therapy Fulltext Access 30 Pages 2018
Antihypertensive potential of linalool and linalool complexed with β-cyclodextrin: Effects of subchronic treatment on blood pressure and vascular reactivity Fulltext Access 30 Pages 2018
The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells Fulltext Access 30 Pages 2018
Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast HTR-8/SVneo cell line Fulltext Access 30 Pages 2018
Quaternary ammonium salt of U50,488H elicits protective effects against hypoxic pulmonary hypertension Fulltext Access 30 Pages 2018
Physcion 8-O-β-glucopyranoside exhibits anti-leukemic activity through targeting sphingolipid rheostat Fulltext Access 30 Pages 2018