Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4 Fulltext Access 32 Pages 2018
Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis Fulltext Access 32 Pages 2018
BMP-2 induces angiogenesis by provoking integrin α6 expression in human endothelial progenitor cells Fulltext Access 32 Pages 2018
Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice Fulltext Access 32 Pages 2018
Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro Fulltext Access 32 Pages 2018
Salidroside alleviates ischemic brain injury in mice with ischemic stroke through regulating BDNK mediated PI3K/Akt pathway Fulltext Access 32 Pages 2018
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment Fulltext Access 32 Pages 2018
Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection Fulltext Access 32 Pages 2018
Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response Fulltext Access 32 Pages 2018
Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets Fulltext Access 32 Pages 2018
The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo Fulltext Access 32 Pages 2018
Eupatilin suppresses the allergic inflammatory response in vitro and in vivo Fulltext Access 32 Pages 2018
A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death Fulltext Access 32 Pages 2018
Identification of quality markers of Yuanhu Zhitong tablets based on integrative pharmacology and data mining Fulltext Access 32 Pages 2018
Identify super quality markers from prototype-based pharmacokinetic markers of Tangzhiqing tablet (TZQ) based on in vitro dissolution/ permeation and in vivo absorption correlations Fulltext Access 32 Pages 2018
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome Fulltext Access 33 Pages 2018
Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats Fulltext Access 33 Pages 2018
Neuroprotective effect of olfactory ensheathing cells co-transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease Fulltext Access 33 Pages 2018
Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity Fulltext Access 33 Pages 2018
Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer Fulltext Access 33 Pages 2018
Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells Fulltext Access 33 Pages 2018
Fibulin-1 interacts with Sex Hormone Binding Globulin and is linked to less aggressive estrogen-dependent breast cancers Fulltext Access 33 Pages 2018
TRPV1 mediates capsaicin-stimulated metabolic activity but not cell death or inhibition of interleukin-1β release in human THP-1 monocytes Fulltext Access 33 Pages 2018
Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway Fulltext Access 33 Pages 2018
Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations Fulltext Access 33 Pages 2018
Functional role of lncRNA LOC101927497 in N-methyl-Nâ²-nitro-N-nitrosoguanidine-induced malignantly transformed human gastric epithelial cells Fulltext Access 33 Pages 2018
The memory ameliorating effects of DHP1402, an herbal mixture, on cholinergic blockade-induced cognitive dysfunction in mice Fulltext Access 33 Pages 2018
Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments Fulltext Access 33 Pages 2018
Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy Fulltext Access 33 Pages 2018
Willughbeia cochinchinensis prevents scopolamine-induced deficits in memory, spatial learning, and object recognition in rodents Fulltext Access 33 Pages 2018
Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model Fulltext Access 33 Pages 2018
Pharmacological activities of the organic extracts and fatty acid composition of the petroleum ether extract from Haplophyllum tuberculatum leaves Fulltext Access 33 Pages 2018
Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis Fulltext Access 33 Pages 2018
The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis Fulltext Access 33 Pages 2018
Ameliorative potential of Lavandula stoechas in metabolic syndrome via multitarget interactions Fulltext Access 33 Pages 2018
Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs Fulltext Access 33 Pages 2018
Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster Fulltext Access 33 Pages 2018
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats Fulltext Access 33 Pages 2018
Attenuation of murine acute lung injury by PF-573,228, an inhibitor of focal adhesion kinase Fulltext Access 33 Pages 2018
Potential role of the ecto-5â²-nucleotidase in morphine-induced uridine release and neurobehavioral changes Fulltext Access 33 Pages 2018
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway Fulltext Access 33 Pages 2018
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis Fulltext Access 33 Pages 2018
Efficacy and tolerability of AFPep, a cyclic peptide with anti-breast cancer properties Fulltext Access 33 Pages 2018
Conditioned gaping produced by high dose Î9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system Fulltext Access 33 Pages 2018
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells Fulltext Access 33 Pages 2018
Fluoxetine or Sox2 reactivate proliferation-defective stem and progenitor cells of the adult and aged dentate gyrus Fulltext Access 33 Pages 2018
COX-2/EP2-EP4/β-catenin signaling regulates patulin-induced intestinal cell proliferation and inflammation Fulltext Access 33 Pages 2018
Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin Fulltext Access 33 Pages 2018
Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng Fulltext Access 33 Pages 2018
Topical application of stem bark ethanol extract of Sonapatha, Oroxylum indicum (L.) Kurz accelerates healing of deep dermal excision wound in Swiss albino mice Fulltext Access 33 Pages 2018
Postnatal overnutrition alters the orexigenic effects of melanin-concentrating hormone (MCH) and reduces MCHR1 hypothalamic expression on spontaneous feeding and fasting Fulltext Access 33 Pages 2018
Population pharmacokinetics of nintedanib in patients with idiopathic pulmonary fibrosis Fulltext Access 33 Pages 2018
NUCB2/nesfatin-1: Expression and functions in the regulation of emotion and stress Fulltext Access 33 Pages 2018
Active forms of Akt and ERK are dominant in the cerebral cortex of newborn pigs that are unaffected by asphyxia Fulltext Access 33 Pages 2018
Decreased contractility and altered responses to inotropic agents in myocytes from tachypacing-induced heart failure canines Fulltext Access 33 Pages 2018
Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection Fulltext Access 33 Pages 2018
Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats Fulltext Access 33 Pages 2018
Antiproliferative effect and ultrastructural alterations induced by 5-O-methylembelin on Trypanosoma cruzi Fulltext Access 33 Pages 2018
Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells Fulltext Access 33 Pages 2018
Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit Fulltext Access 33 Pages 2018
Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production Fulltext Access 33 Pages 2018
Lespedeza cuneata protects the endothelial dysfunction via eNOS phosphorylation of PI3K/Akt signaling pathway in HUVECs Fulltext Access 33 Pages 2018
Effects of Marantodes pumilum (Kacip Fatimah) on vaginal pH and expression of vacoular ATPase and carbonic anhydrase in the vagina of sex-steroid deficient female rats Fulltext Access 33 Pages 2018
Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist Fulltext Access 33 Pages 2018
Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat Fulltext Access 33 Pages 2018
Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer Fulltext Access 33 Pages 2018
Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties Fulltext Access 33 Pages 2018
How Sensitive Are Transdermal Transport Predictions by Microscopic Stratum Corneum Models to Geometric and Transport Parameter Input? Fulltext Access 33 Pages 2018
PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers Fulltext Access 33 Pages 2018
Self-Assembly of α-Cyclodextrin and β-Cyclodextrin: Identification and Development of Analytical Techniques Fulltext Access 33 Pages 2018
Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction Fulltext Access 33 Pages 2018
The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases Fulltext Access 33 Pages 2018
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells Fulltext Access 33 Pages 2018
Partial reversal of the effort-related motivational effects of tetrabenazine with the MAO-B inhibitor deprenyl (selegiline): Implications for treating motivational dysfunctions Fulltext Access 33 Pages 2018
Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen Fulltext Access 33 Pages 2018
Protective effects of stigmasterol against ketamineâinduced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice Fulltext Access 33 Pages 2018
Influences of acephate and mixtures with other commonly used pesticides on honey bee (Apis mellifera) survival and detoxification enzyme activities Fulltext Access 33 Pages 2018
Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans Fulltext Access 33 Pages 2018
Role of K+ channels in regulating spontaneous activity in the muscularis mucosae of guinea pig bladder Fulltext Access 33 Pages 2018
Xanthoceraside attenuates amyloid β peptide1-42-induced memory impairments by reducing neuroinflammatory responses in mice Fulltext Access 33 Pages 2018
miRNA-185 serves as a prognostic factor and suppresses migration and invasion through Wnt1 in colon cancer Fulltext Access 33 Pages 2018
Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model Fulltext Access 33 Pages 2018
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Fulltext Access 33 Pages 2018
Anti-allergic and anti-inflammatory effects of the Bcl-2 inhibitor ABT-737 on experimental allergic rhinitis models Fulltext Access 33 Pages 2018
Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified? Fulltext Access 33 Pages 2018
Fentanyl and naloxone effects on glutamate and GABA release rates from anterior hypothalamus in freely moving rats Fulltext Access 33 Pages 2018
Use of α2-Adrenergic Agonists to Improve Surgical Field Visibility in Endoscopy Sinus Surgery: A Systematic Review of Randomised Controlled Trials Fulltext Access 33 Pages 2018
Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor Fulltext Access 33 Pages 2018
Development of a replicon cell line-based high throughput antiviral assay for screening inhibitors of Zika virus Fulltext Access 33 Pages 2018
Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus Fulltext Access 33 Pages 2018
Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop Fulltext Access 33 Pages 2018
In vitro susceptibility to ST-246 and Cidofovir corroborates the phylogenetic separation of Brazilian Vaccinia virus into two clades Fulltext Access 33 Pages 2018
Anti-respiratory syncytial virus (RSV) G monoclonal antibodies reduce lung inflammation and viral lung titers when delivered therapeutically in a BALB/c mouse model Fulltext Access 33 Pages 2018
Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation Fulltext Access 33 Pages 2018
Multiple antiviral approaches of (-)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in vitro Fulltext Access 33 Pages 2018