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Pharmacology Research Articles

Effect of morin-5′-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to the mercury induced oxidative stress in albino rats
Fulltext Access 7 Pages 2017
Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in nasopharyngeal carcinoma cells by regulating the levels of NADPH and ribose-5-phosphate
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Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer
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Knockdown of HIPK2 attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1
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Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2
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CCL20/CCR6 promotes cell proliferation and metastasis in laryngeal cancer by activating p38 pathway
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miR-98 inhibits hepatocellular carcinoma cell proliferation via targeting EZH2 and suppressing Wnt/β-catenin signaling pathway
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Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer
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Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer
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Overexpression of the long non-coding RNA SPRY4-IT1 promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma
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The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300 m
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Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells
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Inhibition of long non-coding RNA IGF2AS protects apoptosis and neuronal loss in anesthetic-damaged mouse neural stem cell derived neurons
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Enhanced effect of VEGF165 on L-type calcium currents in guinea-pig cardiac ventricular myocytes
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Hp91 immunoadjuvant: An HMGB1-derived peptide for development of therapeutic HPV vaccines
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miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibites cell migration via targeting ZEB1
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Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells
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Evaluation of antibacterial, antioxidant and nootropic activities of Tiliacora racemosa Colebr. leaves: In vitro and in vivo approach
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Effects of a standardized extract of Rheum turkestanicum Janischew root on diabetic changes in the kidney, liver and heart of streptozotocin-induced diabetic rats
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Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats
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Adjuvant effect of Asparagus racemosus Willd. derived saponins in antibody production, allergic response and pro-inflammatory cytokine modulation
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Role of Scoparia dulcis linn on noise-induced nitric oxide synthase (NOS) expression and neurotransmitter assessment on motor function in Wistar albino rats
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MiR-129 regulates cisplatin-resistance in human gastric cancer cells by targeting P-gp
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Salidroside alleviates cigarette smoke-induced COPD in mice
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Place de l'activité physique dans la prise en charge des pathologies neurologiquesThe place of physical activity in the management of neurological pathologies
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Evaluating the potential cancer chemopreventive efficacy of two different solvent extracts of Seriphidium herba-alba in vitro
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Quantitation of camellianin A in HepG2 cells using a high performance liquid chromatography-electrospray ionization tandem mass spectrometric method
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In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice
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Enzymatic biosynthesis of novel neobavaisoflavone glucosides via Bacillus UDP-glycosyltransferase
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UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice
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Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity
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Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury
Fulltext Access 7 Pages 2017
A quantitative analytical method for valienone and its application in the evaluation of valienone production by a breakthrough microbial process
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Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway
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Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects
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TanshinoneIIA enhances the chemosensitivity of breast cancer cells to doxorubicin through down-regulating the expression of MDR-related ABC transporters
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Antioxidant potential of Xylopia aethiopica fruit acetone fraction in a type 2 diabetes model of rats
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Decrease of miR-622 expression promoted the proliferation, migration and invasion of cholangiocarcinoma cells by targeting regulation of c-Myc
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Rôle du pharmacien auprès des patients opiodépendants
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Simultaneous determination of Dimenhydrinate, Cinnarizine and Cinnarizine impurity by TLC and HPLC chromatographic methods
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Quercetin, ascorbic acid, caffeine and ellagic acid are more efficient than rosiglitazone, metformin and glimepiride in interfering with pathways leading to the development of neurological complications associated with diabetes: A comparative in-vitro stu
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Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson's disease in rats
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Chromatographic methods for the simultaneous determination of binary mixture of Saxagliptin HCl and Metformin HCl
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Patients âgés douloureux : démarche clinique infirmière et approches psychocorporelles
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Stimulation par ondes dynamiques profondes auprès des patients douloureux chroniques : présentation et évaluation
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Association between increased EEG signal complexity and cannabis dependence
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Histone deacetylases 3 deletion restrains PM2.5-induced mice lung injury by regulating NF-κB and TGF-β/Smad2/3 signaling pathways
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Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy
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Original articleNOX2-ROS-HIF-1α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation
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Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems
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A field study of hemolymph yolk protein levels in a bivalve (Unio tumidus) and future considerations for bivalve yolk protein as endocrine biomarker
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Original articleA new form of amphotericin B - the complex with copper (II) ions - downregulates sTNFR1 shedding and changes the activity of genes involved in TNF-induced pathways: AmB-Cu2+ downregulates sTNFR1 shedding and changes the activity of g
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N-Heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action
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Pharmacological evaluation of 9,10-dihydrochromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives as potent anti-inflammatory agent
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Original articleIntra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats
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Original articleEsculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway
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Original articleGenetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor
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Original articleThe significance of microRNAs in the course of rDD
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Original articleAcute behavioral effects of co-administration of mephedrone and MDMA in mice
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The effect of PRR ligands on the membrane potential of intestinal epithelial cells
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Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells
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Original articleContribution of dopaminergic and noradrenergic systems in the antinociceptive effect of α-(phenylalanyl) acetophenone
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The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata
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Original articleContribution of the nitric oxide donor molsidomine and the antiparkinsonian drug l-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats
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Developmental expression and regulation of flavin-containing monooxygenase by the unfolded protein response in Japanese medaka (Oryzias latipes)
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Influence of dietary cadmium exposure on fitness traits and its accumulation (with an overview on trace elements) in Lymantria dispar larvae
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Permethrin pesticide induces NURR1 up-regulation in dopaminergic cell line: Is the pro-oxidant effect involved in toxicant-neuronal damage?
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Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids
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Hemolymph and gill carbonic anhydrase are more sensitive to aquatic contamination than mantle carbonic anhydrase in the mangrove oyster Crassostrea rhizophorae
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Characterization of MXR activity in the sea anemone Bunodosoma cangicum exposed to copper
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Questions posées à Madame Véronique Barfety-Servignat, à propos de l'hypocondrie en clinique de la douleur, ou comment brouiller les pistes ?
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La neurostimulation cérébrale non invasive dans les douleurs neuropathiques
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Paliperidone palmitate: factors predicting continuation with treatment at 2 years
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Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects
Fulltext Access 7 Pages 2017
The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism
Fulltext Access 7 Pages 2017
Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase
Fulltext Access 7 Pages 2017
2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents
Fulltext Access 7 Pages 2017
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo
Fulltext Access 7 Pages 2017
ORIGINAL ARTICLEA novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides
Fulltext Access 7 Pages 2017
Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii
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Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3
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Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii
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Establishment and characterization of arsenic trioxide resistant KB/ATO cells
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CCL2/CCR2 signaling pathway in glioblastoma multiforme
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Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?
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Effect of artemisinin on neuropathic pain mediated by P2X4 receptor in dorsal root ganglia
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Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity
Fulltext Access 7 Pages 2017
Protection of PC12 cells from cocaine-induced cell death by inhibiting mitochondrial permeability transition
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Association between high sensitivity CRP and suicidal ideation in the Korean general population
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Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway
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Research articleNicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats
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Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models
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Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects
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Research articleEffects of chronic forced-swim stress on behavioral properties in rats with neonatal repeated MK-801 treatment
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The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice
Fulltext Access 7 Pages 2017
Taurine restores the exploratory behavior following alcohol withdrawal and decreases BDNF mRNA expression in the frontal cortex of chronic alcohol-treated rats
Fulltext Access 7 Pages 2017
Original articleAnti-atherosclerotic effects of pravastatin in brachiocephalic artery in comparison with en face aorta and aortic roots in ApoE/LDLR−/− mice
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Short communicationSearch for new potential anticonvulsants with anxiolytic and antidepressant properties among derivatives of 4,4-diphenylpyrrolidin-2-one
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Original articleToyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells
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Original articleEffect of PGD2 on middle meningeal artery and mRNA expression profile of L-PGD2 synthase and DP receptors in trigeminovascular system and other pain processing structures in rat brain
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