Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism Fulltext Access 7 Pages 2017
Murine genetic variance in muscarinic cholinergic receptor antagonism of sucrose and saccharin solution intakes in three inbred mouse strains Fulltext Access 7 Pages 2017
Divergent cAMP signaling differentially regulates serotonin-induced spinal motor plasticity Fulltext Access 7 Pages 2017
Ca2+-permeable AMPA receptor: A new perspective on amyloid-beta mediated pathophysiology of Alzheimer's disease Fulltext Access 7 Pages 2017
Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists Fulltext Access 7 Pages 2017
The structure and function of glutamate receptors: Mg2+ block to X-ray diffraction Fulltext Access 7 Pages 2017
The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats Fulltext Access 7 Pages 2017
Progress and promise of antisense oligonucleotide therapeutics for central nervous system diseases Fulltext Access 7 Pages 2017
Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice Fulltext Access 7 Pages 2017
Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses Fulltext Access 7 Pages 2017
Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation Fulltext Access 7 Pages 2017
ReviewPost-screenAre placebo and drug-specific effects additive? Questioning basic assumptions of double-blinded randomized clinical trials and presenting novel study designs Fulltext Access 7 Pages 2017
Mechanical Properties and Tableting Behavior of Amorphous Solid Dispersions Fulltext Access 7 Pages 2017
Mimicking the Impact of Infant Tongue Peristalsis on Behavior of Solid Oral Dosage Forms Administered During Breastfeeding Fulltext Access 7 Pages 2017
Application of Artificial Neural Networks in the Design and Optimization of a Nanoparticulate Fingolimod Delivery System Based on Biodegradable Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Fulltext Access 7 Pages 2017
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of ABT-493: A First-In-Human Study Fulltext Access 7 Pages 2017
Mechanisms for Improved Hygroscopicity of L-Arginine Valproate Revealed by X-Ray Single Crystal Structure Analysis Fulltext Access 7 Pages 2017
Application of Dual Protease Column for HDX-MS Analysis of Monoclonal Antibodies Fulltext Access 7 Pages 2017
Liposomogenic UV Absorbers are Water-Resistant on Pig Skin-A Model Study With Relevance for Sunscreens Fulltext Access 7 Pages 2017
Mixed Micelle System Produced by Interaction Between Transglycosylated Stevia and an Ionic Surfactant Improves Dissolution Profile of Mefenamic Acid Fulltext Access 7 Pages 2017
An assessment of sex differences in Î9-tetrahydrocannabinol (THC) taste and place conditioning Fulltext Access 7 Pages 2017
The Pressure-Temperature Phase Diagram of Metacetamol and Its Comparison to the Phase Diagram of Paracetamol Fulltext Access 7 Pages 2017
Safety and Biosimilarity of ior®LeukoCIM Compared to Neupogen® Based on Toxicity, Pharmacodynamic, and Pharmacokinetic Studies in the Sprague-Dawley Rat Fulltext Access 7 Pages 2017
The Delivery of Small Interfering RNA to Hepatic Stellate Cells Using a Lipid Nanoparticle Composed of a Vitamin A-Scaffold Lipid-Like Material Fulltext Access 7 Pages 2017
Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets Fulltext Access 7 Pages 2017
The Keap1-Nrf2 protein-protein interaction: A suitable target for small molecules Fulltext Access 7 Pages 2017
Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration Fulltext Access 7 Pages 2017
ReviewGene-to-screenFeature selection in clinical proteomics: with great power comes great reproducibility Fulltext Access 7 Pages 2017
ReviewPost screenMimicking the ocular environment for the study of inflammatory posterior eye disorders Fulltext Access 7 Pages 2017
ReviewGene-to-screenIdentification and validation of novel drug targets in Mycobacterium tuberculosis Fulltext Access 7 Pages 2017
ReviewPost screenDesigned covalent allosteric modulators: an emerging paradigm in drug discovery Fulltext Access 7 Pages 2017
ReviewPost screenStrategy for large-scale isolation of enantiomers in drug discovery Fulltext Access 7 Pages 2017
ReviewInformaticsThe many roles of molecular complexity in drug discovery Fulltext Access 7 Pages 2017
PerspectiveFeatureAm I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity Fulltext Access 7 Pages 2017
ReviewPost screenEfficacy of non-vitamin-K antagonist oral anticoagulants for intracardiac thrombi resolution in nonvalvular atrial fibrillation Fulltext Access 7 Pages 2017
ReviewGene to screenImproving the economics of NASH/NAFLD treatment through the use of systems biology Fulltext Access 7 Pages 2017
Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression Fulltext Access 7 Pages 2017
PerspectiveFeatureTargeted delivery for regenerative medicines: an untapped opportunity for drug conjugates Fulltext Access 7 Pages 2017
Effects of I2-imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I1-IR and μ-opioid receptor proteins and modulation of associated signalling pathways Fulltext Access 8 Pages 2017
ReviewPost screenPotential therapeutic effects of odorants through their ectopic receptors in pigmented cells Fulltext Access 8 Pages 2017
Discovery of PET radiopharmaceuticals at the academia-industry interface Fulltext Access 8 Pages 2017
ReviewPost screenThe multiple therapeutic applications of miRNAs for bone regenerative medicine Fulltext Access 8 Pages 2017
Discovery and development of SV2A PET tracers: Potential for imaging synaptic density and clinical applications Fulltext Access 8 Pages 2017
ReviewInformaticsThe application of principal component analysis to drug discovery and biomedical data Fulltext Access 8 Pages 2017
ReviewKeynoteEmerging RNA editing biomarkers will foster drug development Fulltext Access 8 Pages 2017
Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1 Fulltext Access 8 Pages 2017
Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1 Fulltext Access 8 Pages 2017
Disruption of transforming growth factor-β superfamily signaling: A shared mechanism underlying hereditary cerebral small vessel disease Fulltext Access 8 Pages 2017
Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke Fulltext Access 8 Pages 2017
In vivo phenotypic screening: clinical proof of concept for a drug repositioning approach Fulltext Access 8 Pages 2017
ReviewKeynoteThe challenges of modulating the 'rest and digest' system: acetylcholine receptors as drug targets Fulltext Access 8 Pages 2017
Bioprinted three dimensional human tissues for toxicology and disease modeling Fulltext Access 8 Pages 2017
ReviewPost screenUnderstanding the checkpoint blockade in lung cancer immunotherapy Fulltext Access 8 Pages 2017
ReviewPost screenProgranulin as a biomarker and potential therapeutic agent Fulltext Access 8 Pages 2017
ReviewInformaticsDeveloping PreDICT - a fully integrated data platform for preclinical in vivo data: learning from experience Fulltext Access 8 Pages 2017
ReviewPost screenNanomedicine-mediated drug targeting of cancer stem cells Fulltext Access 8 Pages 2017
Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4â²,5â²:4,5]thieno(2,3-b)quinoline Fulltext Access 8 Pages 2017
Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity Fulltext Access 8 Pages 2017
Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake Fulltext Access 8 Pages 2017
ORIGINAL ARTICLECloning and expression of three thaumatin-like protein genes from Polyporus umbellatus Fulltext Access 8 Pages 2017
Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice Fulltext Access 8 Pages 2017
Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS Fulltext Access 8 Pages 2017
Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii Fulltext Access 8 Pages 2017
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO) Fulltext Access 8 Pages 2017
ReviewPost screenLipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges Fulltext Access 8 Pages 2017
ReviewPost screenHost-directed therapies offer novel opportunities for the fight against tuberculosis Fulltext Access 8 Pages 2017
ReviewInformaticsImplementing QM in docking calculations: is it a waste of computational time? Fulltext Access 8 Pages 2017
T cell--associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model Fulltext Access 8 Pages 2017
ReviewKeynoteBig data analysis of global advances in pharmaceutics and drug delivery 1980-2014 Fulltext Access 8 Pages 2017
ReviewPost screenUPLC-MS for metabolomics: a giant step forward in support of pharmaceutical research Fulltext Access 8 Pages 2017
In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models Fulltext Access 8 Pages 2017
Syringaresinol-4-O-β-d-glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes Fulltext Access 8 Pages 2017
Approaches to establish Q-markers for the quality standards of traditional Chinese medicines Fulltext Access 8 Pages 2017
ReviewPost screenProtein delivery to the back of the eye: barriers, carriers and stability of anti-VEGF proteins Fulltext Access 8 Pages 2017
Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone Fulltext Access 8 Pages 2017
ReviewPost-screenAntituberculosis drugs: reducing efflux = increasing activity Fulltext Access 8 Pages 2017
ReviewPost screenStructural studies of Mycobacterium tuberculosis DprE1 interacting with its inhibitors Fulltext Access 8 Pages 2017
ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway Fulltext Access 8 Pages 2017
Uncovering novel repositioning opportunities using the Open Targets platform Fulltext Access 8 Pages 2017