Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells Fulltext Access 8 Pages 2008
3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors Fulltext Access 8 Pages 2008
Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules Fulltext Access 8 Pages 2008
Identification and development of new therapeutics for multiple sclerosis Fulltext Access 8 Pages 2008
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1 Fulltext Access 8 Pages 2008
Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS Fulltext Access 8 Pages 2008
Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis—inhibition of aflatoxin B1 metabolism Fulltext Access 8 Pages 2008
Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning Fulltext Access 8 Pages 2008
Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model Fulltext Access 8 Pages 2008
Efficacy of antidotal treatment against sarin poisoning: The superiority of benactyzine and caramiphen Fulltext Access 8 Pages 2008
Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain Fulltext Access 8 Pages 2008
Preferential organ distribution of methylselenol source Se-methylselenocysteine relative to methylseleninic acid Fulltext Access 8 Pages 2008
Inhibition of human placental aromatase activity by hydroxylated polybrominated diphenyl ethers (OH-PBDEs) Fulltext Access 8 Pages 2008
Mechanism of chloroform-induced renal toxicity: Non-involvement of hepatic cytochrome P450-dependent metabolism Fulltext Access 8 Pages 2008
Blood–brain barrier penetration of novel pyridinealdoxime methiodide (PAM)-type oximes examined by brain microdialysis with LC-MS/MS Fulltext Access 8 Pages 2008
Trans, trans-2,4-decadienal induced cell proliferation via p27 pathway in human bronchial epithelial cells Fulltext Access 8 Pages 2008
Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice Fulltext Access 8 Pages 2008
Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes Fulltext Access 8 Pages 2008
Bio-distribution and metabolic paths of silica coated CdSeS quantum dots Fulltext Access 8 Pages 2008
The rat red blood cell proteome is altered by priming with 2-butoxyethanol Fulltext Access 8 Pages 2008
Location, location, locationâ¦site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling Fulltext Access 8 Pages 2008
Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies Fulltext Access 8 Pages 2008
An escort for GPCRs: implications for regulation of receptor density at the cell surface Fulltext Access 8 Pages 2008
Bioactive components from oils of Siwu Decoction and Xiangfu Siwu Decoction by gas chromatography: mass spectrometry and principle components analysis Fulltext Access 8 Pages 2008
Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-κB is dependent upon glutathione depletion in endothelial cells Fulltext Access 8 Pages 2008
Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice Fulltext Access 8 Pages 2008
Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of KATP channel Fulltext Access 8 Pages 2008
Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts Fulltext Access 8 Pages 2008
Pharmacological endothelin receptor interaction does not occur in veins from ETB receptor deficient rats Fulltext Access 8 Pages 2008
Effect of β-escin sodium on endothelial cells proliferation, migration and apoptosis Fulltext Access 8 Pages 2008
A zinc-resistant human epithelial cell line is impaired in cadmium and manganese import Fulltext Access 8 Pages 2008
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke Fulltext Access 8 Pages 2008
Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation Fulltext Access 8 Pages 2008
Antipsychotic drug action: antagonism, inverse agonism or partial agonism Fulltext Access 8 Pages 2008
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis Fulltext Access 8 Pages 2008
Targeting non-multiplying organisms as a way to develop novel antimicrobials Fulltext Access 8 Pages 2008
Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells Fulltext Access 8 Pages 2008
Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes Fulltext Access 8 Pages 2008
Association of oxidative stress with arsenic methylation in chronic arsenic-exposed children and adults Fulltext Access 8 Pages 2008
Estrogen-induced breast cancer: Alterations in breast morphology and oxidative stress as a function of estrogen exposure Fulltext Access 8 Pages 2008
Effects of endogenous hydrogen peroxide and glutathione on the stability of arsenic metabolites in rat bile Fulltext Access 8 Pages 2008
LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism Fulltext Access 8 Pages 2008
Roles of biomarkers in evaluating interactions among mixtures of lead, cadmium and arsenic Fulltext Access 8 Pages 2008
Interleukin-6 production by peritoneal mesothelial cells and its regulation by inflammatory factors in rats administered carbon tetrachloride intraperitoneally Fulltext Access 8 Pages 2008
Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin Fulltext Access 8 Pages 2008
Evaluation of anti-allergic properties of caffeic acid phenethyl ester in a murine model of systemic anaphylaxis Fulltext Access 8 Pages 2008
Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area Fulltext Access 8 Pages 2008
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and β-adrenergic receptor signaling pathways Fulltext Access 8 Pages 2008
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro Fulltext Access 8 Pages 2008
The effects of inhaled corticosteroids on intrinsic responsiveness and histology of airways from infant monkeys exposed to house dust mite allergen and ozone Fulltext Access 8 Pages 2008
Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid Fulltext Access 8 Pages 2008
Protective effect of saponins from Argania spinosa against free radical-induced oxidative haemolysis Fulltext Access 8 Pages 2008
Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells Fulltext Access 8 Pages 2008
Reversal effect of resveratrol on multidrug resistance in KBv200 cell line Fulltext Access 8 Pages 2008
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats Fulltext Access 8 Pages 2008
Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis Fulltext Access 8 Pages 2008
Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative Fulltext Access 8 Pages 2008
Synthesis of 3-(2-pyridyl)-2-substituted-quinazolin-4(3H)-ones as new analgesic and anti-inflammatory agents Fulltext Access 8 Pages 2008
Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F1 mice Fulltext Access 8 Pages 2008
Antioxidant status of erythrocytes and their response to oxidative challenge in humans with argemone oil poisoning Fulltext Access 8 Pages 2008
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells Fulltext Access 8 Pages 2008
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities Fulltext Access 8 Pages 2008
Chlordecone altered hepatic disposition of [14C]cholesterol and plasma cholesterol distribution but not SR-BI or ABCG8 proteins in livers of C57BL/6 mice Fulltext Access 8 Pages 2008
Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors Fulltext Access 8 Pages 2008
Therapy against organophosphate poisoning: The importance of anticholinergic drugs with antiglutamatergic properties Fulltext Access 8 Pages 2008
Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway Fulltext Access 8 Pages 2008
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease Fulltext Access 8 Pages 2008
Surface active stabilizer Tyloxapol in colloidal dispersions exerts cytostatic effects and apoptotic dismissal of cells Fulltext Access 8 Pages 2008
ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta Fulltext Access 8 Pages 2008
Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels Fulltext Access 8 Pages 2008
Protective effect of (−)-epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: A histopathological study Fulltext Access 8 Pages 2008
Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells Fulltext Access 8 Pages 2008
JWA is required for arsenic trioxide induced apoptosis in HeLa and MCF-7 cells via reactive oxygen species and mitochondria linked signal pathway Fulltext Access 8 Pages 2008
The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure Fulltext Access 8 Pages 2008
Variation in the ovine cortisol response to systemic bacterial endotoxin challenge is predominantly determined by signalling within the hypothalamic–pituitary–adrenal axis Fulltext Access 8 Pages 2008
Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes Fulltext Access 8 Pages 2008
Ibuprofen administration attenuates serum TNF-α levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation Fulltext Access 8 Pages 2008
Reaction mechanism underlying the in vitro transformation of thioarsenicals Fulltext Access 8 Pages 2008
Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1 Fulltext Access 8 Pages 2008
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water Fulltext Access 8 Pages 2008
Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats Fulltext Access 8 Pages 2008
Cellular function of neuropathy target esterase in lysophosphatidylcholine action Fulltext Access 8 Pages 2008