Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin Fulltext Access 8 Pages 2008
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method Fulltext Access 8 Pages 2008
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method Fulltext Access 8 Pages 2008
Carnitine in metabolic disease: Potential for pharmacological intervention Fulltext Access 8 Pages 2008
Health effects related to nanoparticle exposures: Environmental, health and safety considerations for assessing hazards and risks Fulltext Access 8 Pages 2008
Nimesulide as a promising neuroprotectant in brain ischemia: New experimental evidences Fulltext Access 8 Pages 2008
Sildenafil augments the beneficial hemodynamic and histopathological effects of amlodipine in nitric oxide-deficient hypertensive rats: Role of nitric oxide–cyclic GMP pathway Fulltext Access 8 Pages 2008
Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation Fulltext Access 8 Pages 2008
Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver Fulltext Access 8 Pages 2008
Expression of amyloid beta peptide in human platelets: Pivotal role of the phospholipase Cγ2-protein kinase C pathway in platelet activation Fulltext Access 8 Pages 2008
Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney Fulltext Access 8 Pages 2008
Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair Fulltext Access 8 Pages 2008
Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis Fulltext Access 8 Pages 2008
Molecular characterization and expression pattern of taurine transporter in zebrafish during embryogenesis Fulltext Access 8 Pages 2008
The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice Fulltext Access 8 Pages 2008
Adipose tissue gene expression profiles in ob/ob mice treated with leptin Fulltext Access 8 Pages 2008
Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease Fulltext Access 8 Pages 2008
Mechanisms of the vasorelaxant effect of 1, 5-dihydroxy-2, 3-dimethoxy-xanthone, an active metabolite of 1-hydroxy-2, 3, 5-trimethoxy-xanthone isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery Fulltext Access 8 Pages 2008
Prevention of chemotherapy-induced alopecia by the anti-death FNK protein Fulltext Access 8 Pages 2008
Pirfenidone inhibits the expression of HSP47 in TGF-β1-stimulated human lung fibroblasts Fulltext Access 8 Pages 2008
Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation Fulltext Access 8 Pages 2008
Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation Fulltext Access 8 Pages 2008
Investigating the role of the hypothalamic supraoptic nucleus in nociception in the rat Fulltext Access 8 Pages 2008
Internalization of mesoporous silica nanoparticles induces transient but not sufficient osteogenic signals in human mesenchymal stem cells Fulltext Access 8 Pages 2008
Suppression of a DNA base excision repair gene, hOGG1, increases bleomycin sensitivity of human lung cancer cell line Fulltext Access 8 Pages 2008
Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity Fulltext Access 8 Pages 2008
In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice Fulltext Access 8 Pages 2008
Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts - A comparative study Fulltext Access 8 Pages 2008
In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni Fulltext Access 8 Pages 2008
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells Fulltext Access 8 Pages 2008
Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury Fulltext Access 8 Pages 2008
PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico Fulltext Access 8 Pages 2008
Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline Fulltext Access 8 Pages 2008
The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats Fulltext Access 8 Pages 2008
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron Fulltext Access 8 Pages 2008
A structure–activity analysis of the variation in oxime efficacy against nerve agents Fulltext Access 8 Pages 2008
Immunotoxicity of aflatoxin B1: Impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression Fulltext Access 8 Pages 2008
Effect of antipsychotic drugs on brain morphometry.: A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapine Fulltext Access 8 Pages 2008
Changes in plasma glycine, l-serine, and d-serine levels in patients with schizophrenia as their clinical symptoms improve: Results from the Juntendo University Schizophrenia Projects (JUSP) Fulltext Access 8 Pages 2008
Reduced efficacy of fluoxetine following MDMA (“Ecstasy”)-induced serotonin loss in rats Fulltext Access 8 Pages 2008
Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains Fulltext Access 8 Pages 2008
Diacylglycerol acyltransferases: Potential roles as pharmacological targets Fulltext Access 8 Pages 2008
The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes Fulltext Access 8 Pages 2008
The intravenous glucose tolerance test in cannulated Wistar rats: A robust method for the in vivo assessment of glucose-stimulated insulin secretion Fulltext Access 8 Pages 2008
Evaluation of Equine Laminar Vein Function: Harvesting, dissection and the use of functional methods to distinguish between veins and arteries Fulltext Access 8 Pages 2008
Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring? Fulltext Access 8 Pages 2008
Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection Fulltext Access 8 Pages 2008
Effects of Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney, gill and spleen of the common carp, Cyprinus carpio L. Fulltext Access 8 Pages 2008
Macrophage immunomodulatory activity of polysaccharides isolated from Glycyrrhiza uralensis fish Fulltext Access 8 Pages 2008
Enhanced susceptibility to Trichuris muris infection of B10Br mice treated with the probiotic Lactobacillus casei Fulltext Access 8 Pages 2008
Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters Fulltext Access 8 Pages 2008
Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning Fulltext Access 8 Pages 2008
Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide Fulltext Access 8 Pages 2008
In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandica Fulltext Access 8 Pages 2008
Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling Fulltext Access 8 Pages 2008
Stimulatory effect of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L., on G-CSF secretion from intestinal epithelial cells Fulltext Access 8 Pages 2008
A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: Implication for a potential anti-inflammatory effect Fulltext Access 8 Pages 2008
AIP1, a carbohydrate fraction from Artemisia iwayomogi, modulates the functional differentiation of bone marrow-derived dendritic cells Fulltext Access 8 Pages 2008
Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: Possible relevance to depression and hyperactive-immune disorders Fulltext Access 8 Pages 2008
Comparison in the effects of IL-2, IL-12, IL-15 and IFNα on gene regulation of granzymes of human NK cell line NK-92 Fulltext Access 8 Pages 2008
Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells Fulltext Access 8 Pages 2008
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats Fulltext Access 8 Pages 2008
Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways Fulltext Access 8 Pages 2008
Establishing the phenotype in novel acute and chronic murine models of allergic asthma Fulltext Access 8 Pages 2008
Inhibition of activated responses in dendritic cells exposed to lipopolysaccharide and lipoteichoic acid by diarylheptanoid oregonin Fulltext Access 8 Pages 2008
Immunomodulatory activity of novel adjuvant formulations based on Montanide ISA oil-based adjuvants and peptidoglycan monomer Fulltext Access 8 Pages 2008
The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species Fulltext Access 8 Pages 2008
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: Effects of early versus delayed treatment Fulltext Access 8 Pages 2008
Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats Fulltext Access 8 Pages 2008
Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo Fulltext Access 8 Pages 2008
Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues Fulltext Access 8 Pages 2008
Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity Fulltext Access 8 Pages 2008
YS 49, 1-(α-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1 Fulltext Access 8 Pages 2008
Triiodothyronine stimulates CMO1 gene expression in human intestinal Caco-2 BBe cells Fulltext Access 8 Pages 2008
Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians Fulltext Access 8 Pages 2008
Endothelin-1 enhances proliferation of lung cancer cells by increasing intracellular free Ca2+ Fulltext Access 8 Pages 2008
A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity Fulltext Access 8 Pages 2008
Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic β-cell line NES2Y Fulltext Access 8 Pages 2008
Synergistic effects of multiple natural products in pancreatic cancer cells Fulltext Access 8 Pages 2008
Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis Fulltext Access 8 Pages 2008
Na-Tosyl-Phe chloromethyl ketone prevents granule movement and mast cell synergistic degranulation elicited by costimulation of antigen and adenosine Fulltext Access 8 Pages 2008
Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery Fulltext Access 8 Pages 2008
Possible autocrine enkephalin regulation of catecholamine release in human pheochromocytoma cells Fulltext Access 8 Pages 2008
DMNQ-S17 inhibits constitutive NF-kappaB activation leading to induction of apoptosis through the activation of caspase-3 in human myeloid leukemia U937 cells Fulltext Access 8 Pages 2008
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice Fulltext Access 8 Pages 2008
Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydroxy-quinone Fulltext Access 8 Pages 2008
Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: Beyond QT prolongation Fulltext Access 8 Pages 2008
Comparison of different pharmacodynamic models for PK–PD modeling of verapamil in renovascular hypertension Fulltext Access 8 Pages 2008
Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia Fulltext Access 8 Pages 2008
How many ECG leads are required for in vivo studies in safety pharmacology? Fulltext Access 8 Pages 2008