Characterization of A-425619 at native TRPV1 receptors: A comparison between dorsal root ganglia and trigeminal ganglia Fulltext Access 8 Pages 2008
Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission Fulltext Access 8 Pages 2008
Melatonin attenuates tyrosine hydroxylase loss and hypolocomotion in MPTP-lesioned rats Fulltext Access 8 Pages 2008
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice Fulltext Access 8 Pages 2008
Genistein inhibits aldose reductase activity and high glucose-induced TGF-β2 expression in human lens epithelial cells Fulltext Access 8 Pages 2008
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation Fulltext Access 8 Pages 2008
A protective role of unfolded protein response in mouse ischemic acute kidney injury Fulltext Access 8 Pages 2008
Persistence of tolerance to the anaesthetic effect of allopregnanolone in male rats Fulltext Access 8 Pages 2008
Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells Fulltext Access 8 Pages 2008
Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion Fulltext Access 8 Pages 2008
Metoprolol increases the expression of β3-adrenoceptors in the diabetic heart: Effects on nitric oxide signaling and forkhead transcription factor-3 Fulltext Access 8 Pages 2008
Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally Fulltext Access 8 Pages 2008
The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat Fulltext Access 8 Pages 2008
Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: Role of serotonin Fulltext Access 8 Pages 2008
DDTD, an isoflavone derivative, induces cell apoptosis through the reactive oxygen species/apoptosis signal-regulating kinase 1 pathway in human osteosarcoma cells Fulltext Access 8 Pages 2008
Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats Fulltext Access 8 Pages 2008
A pharmacological comparison of the cloned frog and human mu opioid receptors reveals differences in opioid affinity and function Fulltext Access 8 Pages 2008
Protocatechuic acid from Alpinia oxyphylla promotes migration of human adipose tissue-derived stromal cells in vitro Fulltext Access 8 Pages 2008
SONU20176289, a compound combining partial dopamine D2 receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression Fulltext Access 8 Pages 2008
Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations Fulltext Access 8 Pages 2008
Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-κB signaling pathways Fulltext Access 8 Pages 2008
Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678 Fulltext Access 8 Pages 2008
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts Fulltext Access 8 Pages 2008
S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis Fulltext Access 8 Pages 2008
Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells Fulltext Access 8 Pages 2008
Alpha anomer of 5-aza-2â²-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells Fulltext Access 8 Pages 2008
Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the dimerization of inducible nitric oxide synthase Fulltext Access 8 Pages 2008
Proteasomal inhibition stabilizes topoisomerase IIα protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide) Fulltext Access 8 Pages 2008
Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells Fulltext Access 8 Pages 2008
Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: A role of hyperphosphorylation of PKCε Fulltext Access 8 Pages 2008
Adenosine rescues glioma cells from cytokine-induced death by interfering with the signaling network involved in nitric oxide production Fulltext Access 8 Pages 2008
Induction of dopamine biosynthesis by l-DOPA in PC12 cells: Implications of l-DOPA influx and cyclic AMP Fulltext Access 8 Pages 2008
Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestine Fulltext Access 8 Pages 2008
Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1 Fulltext Access 8 Pages 2008
Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation Fulltext Access 8 Pages 2008
Cloning and characterization of the monkey histamine H3 receptor isoforms Fulltext Access 8 Pages 2008
Lithium-induced suppression of transcription repressor NRSF/REST: Effects on the dysfunction of neuronal differentiation by ethanol Fulltext Access 8 Pages 2008
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes Fulltext Access 8 Pages 2008
YM-341619 suppresses the differentiation of spleen T cells into Th2 cells in vitro, eosinophilia, and airway hyperresponsiveness in rat allergic models Fulltext Access 8 Pages 2008
Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum Fulltext Access 8 Pages 2008
Protective effects of pyrrolidine dithiocarbamate against airway inflammation in the ovalbumin-induced mouse model Fulltext Access 8 Pages 2008
Enhancement of active shuttle avoidance response by the NO-cGMP-PKG activator YC-1 Fulltext Access 8 Pages 2008
Behavioural and neurotoxic long-lasting effects of MDMA plus cocaine in adolescent mice Fulltext Access 8 Pages 2008
Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT1A receptor populations: A study in SERT knockout rats Fulltext Access 8 Pages 2008
Brain neuronal/inducible nitric oxide synthases and cyclooxygenase-1 are involved in the bombesin-induced activation of central adrenomedullary outflow in rats Fulltext Access 8 Pages 2008
Bioisosteric phentolamine analogs as selective human α2- versus α1-adrenoceptor ligands Fulltext Access 8 Pages 2008
Cell adhesion modulates 5-HT1D and P2Y receptor signal trafficking differentially in LTK-8 cells Fulltext Access 8 Pages 2008
In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat Fulltext Access 8 Pages 2008
Enantioselective effect of 12(S)-hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 MAPK pathways and cyclin D1 activation Fulltext Access 8 Pages 2008
Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver Fulltext Access 8 Pages 2008
The pharmacology and molecular mechanisms underlying temperature regulation and torpor Fulltext Access 8 Pages 2008
Thermodynamics of A2B adenosine receptor binding discriminates agonistic from antagonistic behaviour Fulltext Access 8 Pages 2008
Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel Fulltext Access 8 Pages 2008
KATP channel openers: Tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides Fulltext Access 8 Pages 2008
Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells Fulltext Access 8 Pages 2008
Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7 Fulltext Access 8 Pages 2008
Accumulation of the antimalarial microtubule inhibitors trifluralin and vinblastine by Plasmodium falciparum Fulltext Access 8 Pages 2008
New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets Fulltext Access 8 Pages 2008
Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats Fulltext Access 8 Pages 2008
The reversibility of neurofilaments decline induced by 2,5-hexanedione in rat nerve tissues Fulltext Access 8 Pages 2008
Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer Fulltext Access 8 Pages 2008
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERα ligands and ERRα ligands Fulltext Access 8 Pages 2008
Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines Fulltext Access 8 Pages 2008
The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines Fulltext Access 8 Pages 2008
Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans Fulltext Access 8 Pages 2008
Structure–activity relationship of (−) mammea A/BB derivatives against Leishmania amazonensis Fulltext Access 8 Pages 2008
Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells Fulltext Access 8 Pages 2008
An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells Fulltext Access 8 Pages 2008
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase Fulltext Access 8 Pages 2008
A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons Fulltext Access 8 Pages 2008
Fructose Induced Leptin Dysfunction and Improvement by Quercetin and Rutin in Rats Fulltext Access 8 Pages 2008
Oxidative stress and erythrocyte acetylcholinesterase (AChE) in hypertensive and ischemic patients of both acute and chronic stages Fulltext Access 8 Pages 2008
Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: Role of suppressor of cytokine signaling Fulltext Access 8 Pages 2008
Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid Fulltext Access 8 Pages 2008
Nuclear medicine procedures in the diagnosis and therapy of medullary thyroid carcinoma Fulltext Access 8 Pages 2008
Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis Fulltext Access 8 Pages 2008
Paeoniflorin suppress NF-κB activation through modulation of IκBα and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells Fulltext Access 8 Pages 2008
Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors Fulltext Access 8 Pages 2008
Structure-activity relationship, selectivity and mode of inhibition of terminal deoxyribonucleotidyltransferaseby streptolydigin analogs Fulltext Access 8 Pages 2008
Effect of cadmium ingestion on cadmium and zinc profile in male and female rat liver cytosol Fulltext Access 8 Pages 2008
Up-regulation of nicotinic acetylcholine receptors following chronic exposure of rats to mainstream cigarette smoke or α4β2 receptors to nicotine Fulltext Access 8 Pages 2008
Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus Fulltext Access 8 Pages 2008
A facile method to screen inhibitors of protein–protein interactions including MDM2–p53 displayed on T7 phage Fulltext Access 8 Pages 2008
Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A) Fulltext Access 8 Pages 2008
Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL Fulltext Access 8 Pages 2008
STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets Fulltext Access 8 Pages 2008
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: Effects on the thioredoxin system Fulltext Access 8 Pages 2008
Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 (hENT1) enhances gemcitabine response in human pancreatic cancer Fulltext Access 8 Pages 2008
Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2 Fulltext Access 8 Pages 2008