Quercetin accelerates TNF-α-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways Fulltext Access 8 Pages 2008
Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice Fulltext Access 8 Pages 2008
Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate Fulltext Access 8 Pages 2008
A mouse model of depression induced by repeated corticosterone injections Fulltext Access 8 Pages 2008
Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay Fulltext Access 8 Pages 2008
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia Fulltext Access 8 Pages 2008
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries Fulltext Access 8 Pages 2008
Enhanced expression of contractile endothelin ETB receptors in rat coronary artery after organ culture Fulltext Access 8 Pages 2008
Meperidine, remifentanil and tramadol but not sufentanil interact with α2-adrenoceptors in α2A-, α2B- and α2C-adrenoceptor knock out mice brain Fulltext Access 8 Pages 2008
Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats Fulltext Access 8 Pages 2008
Central CRH system in depression and anxiety — Evidence from clinical studies with CRH1 receptor antagonists Fulltext Access 8 Pages 2008
Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo Fulltext Access 8 Pages 2008
The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems Fulltext Access 8 Pages 2008
Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia Fulltext Access 8 Pages 2008
Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine Fulltext Access 8 Pages 2008
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia Fulltext Access 8 Pages 2008
Protective effects of ACE inhibitors on vascular endothelial dysfunction induced by exogenous advanced oxidation protein products in rats Fulltext Access 8 Pages 2008
Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells Fulltext Access 8 Pages 2008
Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats Fulltext Access 8 Pages 2008
Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability Fulltext Access 8 Pages 2008
Hesperidin a flavanoglycone protects against γ-irradiation induced hepatocellular damage and oxidative stress in Sprague–Dawley rats Fulltext Access 8 Pages 2008
Relaxations to β-adrenoceptor subtype selective agonists in wild-type and NOS-3-KO mouse mesenteric arteries Fulltext Access 8 Pages 2008
Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-β1/Smad 7 expression in the spontaneously hypertensive rats Fulltext Access 8 Pages 2008
Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats Fulltext Access 8 Pages 2008
The role of gonadal hormones on opioid receptor protein density in arthritic rats Fulltext Access 8 Pages 2008
Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production Fulltext Access 8 Pages 2008
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors Fulltext Access 8 Pages 2008
Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells Fulltext Access 8 Pages 2008
Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: Role of cyclooxygenase metabolites Fulltext Access 8 Pages 2008
Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice Fulltext Access 8 Pages 2008
Chronic valproate normalizes behavior in mice overexpressing calcineurin Fulltext Access 8 Pages 2008
Differential effects of isoflurane on A-type and delayed rectifier K channels in rat substantia nigra Fulltext Access 8 Pages 2008
Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats Fulltext Access 8 Pages 2008
Identification of potent agonists acting at an endogenous atypical β3-adrenoceptor state that modulate lipolysis in rodent fat cells Fulltext Access 8 Pages 2008
Hepatocyte growth factor increases uptake of estradiol 17β-d-glucuronide and Oatp1 protein level in rat hepatocytes Fulltext Access 8 Pages 2008
Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys Fulltext Access 8 Pages 2008
Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages Fulltext Access 8 Pages 2008
YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity Fulltext Access 8 Pages 2008
Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice Fulltext Access 8 Pages 2008
Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways Fulltext Access 8 Pages 2008
In vivo glycyrrhizin accelerates liver regeneration and rapidly lowers serum transaminase activities in 70% partially hepatectomized rats Fulltext Access 8 Pages 2008
Conjugated linoleic acid and cardiac health: Oxidative stress and energetic metabolism in standard and sucrose-rich diets Fulltext Access 8 Pages 2008
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: Comparison to morphine Fulltext Access 8 Pages 2008
Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain Fulltext Access 8 Pages 2008
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy Fulltext Access 8 Pages 2008
Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells Fulltext Access 8 Pages 2008
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model Fulltext Access 8 Pages 2008
Characterization of the unique regulatory mechanisms of phorbol ester-induced polymorphonuclear leukocyte spreading in an acidified environment Fulltext Access 8 Pages 2008
Effects of angiotensin II and its metabolites in the rat coronary vascular bed: Is angiotensin III the preferred ligand of the angiotensin AT2 receptor? Fulltext Access 8 Pages 2008
Baicalein protects chicken embryonic cardiomyocyte against hypoxia–reoxygenation injury via μ- and δ- but not κ-opioid receptor signaling Fulltext Access 8 Pages 2008
Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: A comparative study of coupling to Gαs Fulltext Access 8 Pages 2008
Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences Fulltext Access 8 Pages 2008
The Wnt/frizzled pathway in cardiovascular development and disease: Friend or foe? Fulltext Access 8 Pages 2008
Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: Involvement of the peripheral autonomic nervous system Fulltext Access 8 Pages 2008
Spironolactone exhibits direct renoprotective effects and inhibits renal renin–angiotensin–aldosterone system in diabetic rats Fulltext Access 8 Pages 2008
Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice Fulltext Access 8 Pages 2008
Additive subthreshold dose effects of cannabinoid CB1 receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests Fulltext Access 8 Pages 2008
Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats Fulltext Access 8 Pages 2008
Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain Fulltext Access 8 Pages 2008
Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate Fulltext Access 8 Pages 2008
β-adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells Fulltext Access 8 Pages 2008
Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: Inhibition of microglial neurotoxicity Fulltext Access 8 Pages 2008
Inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase thapsigargin stimulates production of nitric oxide and secretion of interferon-gamma Fulltext Access 8 Pages 2008
Epileptogenesis causes an N-methyl-d-aspartate receptor/Ca2+-dependent decrease in Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent epileptiform discharges Fulltext Access 8 Pages 2008
Transcriptional down-regulation of human α2A-adrenoceptors by IFNγ and TNFα in intestinal cells Fulltext Access 8 Pages 2008
Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-β peptides Fulltext Access 8 Pages 2008
Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin Fulltext Access 8 Pages 2008
Lycopene inhibits TNF-α-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion Fulltext Access 8 Pages 2008
(+)-Morphine attenuates the (â)-morphine-produced conditioned place preference and the µ-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat Fulltext Access 8 Pages 2008
Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats Fulltext Access 8 Pages 2008
Interferon-α enhances artemisinin-induced differentiation of HL-60 leukemia cells via a PKCα/ERK pathway Fulltext Access 8 Pages 2008
Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells Fulltext Access 8 Pages 2008
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists Fulltext Access 8 Pages 2008
Resveratrol attenuates thromboxane A2 receptor agonist-induced platelet activation by reducing phospholipase C activity Fulltext Access 8 Pages 2008
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease Fulltext Access 8 Pages 2008
Comparison of the opioid receptor antagonist properties of naltrexone and 6β-naltrexol in morphine-naïve and morphine-dependent mice Fulltext Access 8 Pages 2008
d-LSD-induced c-Fos expression occurs in a population of oligodendrocytes in rat prefrontal cortex Fulltext Access 8 Pages 2008
Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline Fulltext Access 8 Pages 2008
Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms Fulltext Access 8 Pages 2008
Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice Fulltext Access 8 Pages 2008
Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-κB and reduces myocardial infarct size in rats Fulltext Access 8 Pages 2008
Therapeutic effect of magnesium lithospermate B on neointimal formation after balloon-induced vascular injury Fulltext Access 8 Pages 2008
Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210 Fulltext Access 8 Pages 2008
Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice Fulltext Access 8 Pages 2008
Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of citalopram in conditioned fear stress in the rat Fulltext Access 8 Pages 2008
Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain Fulltext Access 8 Pages 2008
Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3β in adrenal chromaffin cells: Effects of LiCl and SB216763 Fulltext Access 8 Pages 2008
YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells Fulltext Access 8 Pages 2008
Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells Fulltext Access 8 Pages 2008
Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor Fulltext Access 8 Pages 2008
Metalloporphyrins as a therapeutic drug class against peroxynitrite in cardiovascular diseases involving ischemic reperfusion injury Fulltext Access 8 Pages 2008