Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders Fulltext Access 8 Pages 2008
Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts Fulltext Access 8 Pages 2008
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines Fulltext Access 8 Pages 2008
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats Fulltext Access 8 Pages 2008
Cardiovascular effects of l-glutamate injected in the medial prefrontal cortex of spontaneously hypertensive rats Fulltext Access 8 Pages 2008
In vitro inhibition of enterobacteria-reactive CD4+CD25− T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027 Fulltext Access 9 Pages 2008
Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury Fulltext Access 9 Pages 2008
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis Fulltext Access 9 Pages 2008
Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells Fulltext Access 9 Pages 2008
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors Fulltext Access 9 Pages 2008
A novel benzotriazole derivative inhibits proliferation of human hepatocarcinoma cells by increasing oxidative stress concomitant mitochondrial damage Fulltext Access 9 Pages 2008
Decreased basal endogenous opioid levels in diabetic rodents: Effects on morphine and delta-9-tetrahydrocannabinoid-induced antinociception Fulltext Access 9 Pages 2008
Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3 Fulltext Access 9 Pages 2008
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain Fulltext Access 9 Pages 2008
Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation Fulltext Access 9 Pages 2008
Use and abuse of QT and TRIaD in cardiac safety research: Importance of study design and conduct Fulltext Access 9 Pages 2008
Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism Fulltext Access 9 Pages 2008
Involvement of dorsal hippocampal nicotinic receptors in the effect of morphine on memory retrieval in passive avoidance task Fulltext Access 9 Pages 2008
In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR 3394 in 6-hydroxydopamine lesioned rats Fulltext Access 9 Pages 2008
Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCζ activation Fulltext Access 9 Pages 2008
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers Fulltext Access 9 Pages 2008
Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells Fulltext Access 9 Pages 2008
Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents Fulltext Access 9 Pages 2008
Expression and characterization of the human α2B-adrenoceptor in a vascular smooth muscle cell line Fulltext Access 9 Pages 2008
Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through Gαq/11 Fulltext Access 9 Pages 2008
Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model Fulltext Access 9 Pages 2008
Relative impact of residues at the intracellular and extracellular ends of the human GABAC ρ1 receptor M2 domain on picrotoxinin activity Fulltext Access 9 Pages 2008
Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats Fulltext Access 9 Pages 2008
Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets Fulltext Access 9 Pages 2008
Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile Fulltext Access 9 Pages 2008
Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium Fulltext Access 9 Pages 2008
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens Fulltext Access 9 Pages 2008
Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants Fulltext Access 9 Pages 2008
Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes) Fulltext Access 9 Pages 2008
Single exposure to erythropoietin modulates Nerve Growth Factor expression in the spinal cord following traumatic injury: Comparison with methylprednisolone Fulltext Access 9 Pages 2008
Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma Fulltext Access 9 Pages 2008
Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats Fulltext Access 9 Pages 2008
The role of multi-drug resistance p-glycoprotein in glucocorticoid function: Studies in animals and relevance in humans Fulltext Access 9 Pages 2008
Role of Ca2+-sensitization in attenuated carbachol-induced contraction of the colon in a rat model of colitis Fulltext Access 9 Pages 2008
p38-MAPK is involved in restoration of the lost protection of preconditioning by nicorandil in vivo Fulltext Access 9 Pages 2008
Contribution of soluble intercellular adhesion molecule-1 to the migration of vascular smooth muscle cells Fulltext Access 9 Pages 2008
Acute administration of l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats Fulltext Access 9 Pages 2008
Role of nociceptin/orphanin FQ and the pseudopeptide [Phe1Ψ(CH2NH)Gly2]-nociceptin(1–13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersa Fulltext Access 9 Pages 2008
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism Fulltext Access 9 Pages 2008
Role of tachykinin NK1 and NK2 receptors in colonic sensitivity and stress-induced defecation in gerbils Fulltext Access 9 Pages 2008
Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells Fulltext Access 9 Pages 2008
Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-κB Fulltext Access 9 Pages 2008
Corticosteroid receptor polymorphisms: Determinants of vulnerability and resilience Fulltext Access 9 Pages 2008
Cytochrome P450 ω-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion Fulltext Access 9 Pages 2008
Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis Fulltext Access 9 Pages 2008
The human angiotensin AT1 receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation Fulltext Access 9 Pages 2008
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Fulltext Access 9 Pages 2008
Dual role of hydrogen sulfide in mechanical inflammatory hypernociception Fulltext Access 9 Pages 2008
γ-Radiation induces apoptosis via sarcoplasmatic reticulum in guinea pig ileum smooth muscle cells Fulltext Access 9 Pages 2008
Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors Fulltext Access 9 Pages 2008
Nitric oxide and glutamate in the dorsal facial area regulate common carotid blood flow in the cat Fulltext Access 9 Pages 2008
Involvement of activating transcription factors JNK, NF-κB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex Fulltext Access 9 Pages 2008
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy Fulltext Access 9 Pages 2008
Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis Fulltext Access 9 Pages 2008
Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine Fulltext Access 9 Pages 2008
STI571 and morpholine derivative of doxorubicin collaborate in inhibition of K562 cell proliferation by inducing differentiation and mitochondrial pathway of apoptosis Fulltext Access 9 Pages 2008
The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human α1A1-adrenoceptors Fulltext Access 9 Pages 2008
Stimulated calcium entry and constitutive RhoA kinase activity cause stretch-induced detrusor contraction Fulltext Access 9 Pages 2008
Amphetamine- and cocaine-induced conditioned place preference and concomitant psychomotor sensitization in mice with genetically inactivated melanin-concentrating hormone MCH1 receptor Fulltext Access 9 Pages 2008
Blockade of cytosolic phospholipase A2 and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A Fulltext Access 9 Pages 2008
Activation of cholecystokinin (CCK1) and serotonin (5-HT3) receptors increases the discharge of pancreatic vagal afferents Fulltext Access 9 Pages 2008
Modulatory role of endogenous androgens on airway smooth muscle tone in isolated guinea-pig and bovine trachea; involvement of β2-adrenoceptors, the polyamine system and external calcium Fulltext Access 9 Pages 2008
Minocycline prevents the development of neuropathic pain, but not acute pain: Possible anti-inflammatory and antioxidant mechanisms Fulltext Access 9 Pages 2008
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase Fulltext Access 9 Pages 2008
S1P receptor signalling and RGS proteins; expression and function in vascular smooth muscle cells and transfected CHO cells Fulltext Access 9 Pages 2008
Immune modulation and graft protection by gene therapy in kidney transplantation Fulltext Access 9 Pages 2008
Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence Fulltext Access 9 Pages 2008
5-HT1A receptor-mediated activation of a G-protein-coupled inwardly rectifying K+ current in rat medial preoptic area neurons Fulltext Access 9 Pages 2008
Tournefolic acid B attenuates amyloid β protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons Fulltext Access 9 Pages 2008
Hyperglycaemia as a determinant of cognitive decline in patients with type 1 diabetes Fulltext Access 9 Pages 2008
Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts Fulltext Access 9 Pages 2008
Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects Fulltext Access 9 Pages 2008
Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats Fulltext Access 9 Pages 2008
Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine Fulltext Access 9 Pages 2008
Tissue transglutaminase: A novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases Fulltext Access 9 Pages 2008
Haemodynamic effects of vasoactive agents following chronic state of high cardiac output in anaesthetized rats Fulltext Access 9 Pages 2008
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys Fulltext Access 9 Pages 2008
Trehalose: A biophysics approach to modulate the inflammatory response during endotoxic shock Fulltext Access 9 Pages 2008
Involvement of soluble guanylate cyclase α1 and α2, and SKCa channels in NANC relaxation of mouse distal colon Fulltext Access 9 Pages 2008
Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats Fulltext Access 9 Pages 2008
Small-conductance Ca2+-activated K+ channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers Fulltext Access 9 Pages 2008
Glutamate preconditioning prevents neuronal death induced by combined oxygen–glucose deprivation in cultured cortical neurons Fulltext Access 9 Pages 2008
20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells Fulltext Access 9 Pages 2008
Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves Fulltext Access 9 Pages 2008
Oral clonidine inhibits visceral pain-related viscerosomatic and cardiovascular responses to colorectal distension in rats Fulltext Access 9 Pages 2008
Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer Fulltext Access 9 Pages 2008
Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism Fulltext Access 9 Pages 2008