Identification of two biologically crucial hydroxyl groups of (−)-epigallocatechin gallate in osteoclast culture Fulltext Access 10 Pages 2007
Regulatory mechanisms underlying GKR2 levels in U937 cells: Evidence for GRK3 involvement Fulltext Access 10 Pages 2007
Agonist-stimulated reactive oxygen species formation regulates β2-adrenergic receptor signal transduction Fulltext Access 10 Pages 2007
Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells Fulltext Access 10 Pages 2007
Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways Fulltext Access 10 Pages 2007
Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase Fulltext Access 10 Pages 2007
Discovery of Trp-Nle-Tyr-Met as a novel agonist for human formyl peptide receptor-like 1 Fulltext Access 10 Pages 2007
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor Fulltext Access 10 Pages 2007
Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability Fulltext Access 10 Pages 2007
Involvement of reactive oxygen species on the apoptotic mechanism induced by IFN-α2b in rat preneoplastic liver Fulltext Access 10 Pages 2007
Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP) Fulltext Access 10 Pages 2007
Gene expression and regulation of drug transporters in the intestine and kidney Fulltext Access 10 Pages 2007
Chain length dependence of the interactions of bisquaternary ligands with the Torpedo nicotinic acetylcholine receptor Fulltext Access 10 Pages 2007
Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cδ-dependent manner Fulltext Access 10 Pages 2007
Acylation with diangeloyl groups at C21–22 positions in triterpenoid saponins is essential for cytotoxcity towards tumor cells Fulltext Access 10 Pages 2007
Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines Fulltext Access 10 Pages 2007
Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest Fulltext Access 10 Pages 2007
Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells Fulltext Access 10 Pages 2007
Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4â²-hydroxymethyl-α-pyrrolidinobutyrophenone Fulltext Access 10 Pages 2007
The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation Fulltext Access 10 Pages 2007
Effects of Salviae Mitiorrhizae and Cortex Moutan extract on the rat heart after myocardial infarction: A proteomic study Fulltext Access 10 Pages 2007
Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells Fulltext Access 10 Pages 2007
Accumulation of γ-globin mRNA and induction of irreversible erythroid differentiation after treatment of CML cell line K562 with new doxorubicin derivatives Fulltext Access 10 Pages 2007
Effects of (R,S)/(S,R)-4,5-bis(2-chloro-4-hydroxyphenyl)-2-imidazolines and (R,S)/(S,R)-2,3-bis(2-chloro-4-hydroxyphenyl)piperazines on estrogen receptor alpha level and transcriptional activity in MCF-7 cells Fulltext Access 10 Pages 2007
Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and α-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol Fulltext Access 10 Pages 2007
Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists Fulltext Access 10 Pages 2007
In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for μ-opioid receptors, on mouse colonic motility Fulltext Access 10 Pages 2007
Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries Fulltext Access 10 Pages 2007
Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma Fulltext Access 10 Pages 2007
Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([{trans-PtCl(NH3)2}2μ-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+) influenced by copper homeostasis Fulltext Access 10 Pages 2007
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent Fulltext Access 10 Pages 2007
Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases Fulltext Access 10 Pages 2007
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation Fulltext Access 10 Pages 2007
Intrathecal substance P (1–7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade Fulltext Access 10 Pages 2007
Prodelphinidin B-4 3′-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-κB pathway Fulltext Access 10 Pages 2007
Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors Fulltext Access 10 Pages 2007
Functional consequences of methionine oxidation of hERG potassium channels Fulltext Access 10 Pages 2007
Histamine augments β2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors Fulltext Access 10 Pages 2007
Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate Fulltext Access 10 Pages 2007
Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells Fulltext Access 10 Pages 2007
The changes of intracellular H2O2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells Fulltext Access 10 Pages 2007
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines Fulltext Access 11 Pages 2007
NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis Fulltext Access 11 Pages 2007
Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia Fulltext Access 11 Pages 2007
Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation Fulltext Access 11 Pages 2007
Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels Fulltext Access 11 Pages 2007
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes Fulltext Access 11 Pages 2007
Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells Fulltext Access 11 Pages 2007
AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells Fulltext Access 11 Pages 2007
2′,4′,6′-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-α-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways Fulltext Access 11 Pages 2007
Trypanocidal nitroimidazole derivatives: Relationships among chemical structure and genotoxic activity Fulltext Access 11 Pages 2007
Sulfated cyclodextrins inhibit the entry of Plasmodium into red blood cells: Implications for malarial therapy Fulltext Access 11 Pages 2007
Effects of chronic opioid exposure on guinea pig mu opioid receptor in Chinese hamster ovary cells: Comparison with human and rat receptor Fulltext Access 11 Pages 2007
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates Fulltext Access 11 Pages 2007
Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway Fulltext Access 11 Pages 2007
Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists Fulltext Access 11 Pages 2007
The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition Fulltext Access 11 Pages 2007
The activation by estrogen receptor agonists of the BKCa-channel in human cardiac fibroblasts Fulltext Access 11 Pages 2007
Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress Fulltext Access 11 Pages 2007
Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases Fulltext Access 11 Pages 2007
Deglycosylated bleomycin induces apoptosis in lymphoma cell via c-jun NH2-terminal kinase but not reactive oxygen species Fulltext Access 11 Pages 2007
Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation Fulltext Access 11 Pages 2007
Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway Fulltext Access 11 Pages 2007
Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells Fulltext Access 11 Pages 2007
Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity Fulltext Access 11 Pages 2007
Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q) Fulltext Access 11 Pages 2007
Identification of novel bradykinin-potentiating peptides (BPPs) in the venom gland of a rattlesnake allowed the evaluation of the structure–function relationship of BPPs Fulltext Access 11 Pages 2007
Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells Fulltext Access 11 Pages 2007
Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes Fulltext Access 11 Pages 2007
Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity Fulltext Access 11 Pages 2007
Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway Fulltext Access 11 Pages 2007
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults Fulltext Access 11 Pages 2007
Involvement of alcohol and aldehyde dehydrogenase activities on hepatic retinoid metabolism and its possible participation in the progression of rat liver regeneration Fulltext Access 11 Pages 2007
Neutral and positively charged thiols synergize the effect of the immunomodulator AS101 as a growth inhibitor of Jurkat cells, by increasing its uptake Fulltext Access 11 Pages 2007
Inhibition of the intestinal absorption of bile acids using cationic derivatives: Mechanism and repercussions Fulltext Access 11 Pages 2007
Mechanism of acridine-based telomerase inhibition and telomere shortening Fulltext Access 11 Pages 2007
Diclofenac hydroxylation in monkeys: Efficiency, regioselectivity, and response to inhibitors Fulltext Access 11 Pages 2007
Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-κB-dependent pathway in human lung cancer cells Fulltext Access 11 Pages 2007
Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells Fulltext Access 11 Pages 2007
Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice Fulltext Access 11 Pages 2007
Methylglyoxal suppresses TNF-α-induced NF-κB activation by inhibiting NF-κB DNA-binding Fulltext Access 11 Pages 2007
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation Fulltext Access 11 Pages 2007
Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3β expression, while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation Fulltext Access 11 Pages 2007
13-Oxo-ODE is an endogenous ligand for PPARγ in human colonic epithelial cells Fulltext Access 11 Pages 2007
Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells Fulltext Access 11 Pages 2007
Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells Fulltext Access 11 Pages 2007
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D2 Fulltext Access 11 Pages 2007
The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells Fulltext Access 11 Pages 2007
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult Fulltext Access 11 Pages 2007
Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus Fulltext Access 11 Pages 2007
The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events Fulltext Access 11 Pages 2007
PGD2 metabolism in plasma: Kinetics and relationship with bioactivity on DP1 and CRTH2 receptors Fulltext Access 11 Pages 2007
HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-α + TSA Fulltext Access 11 Pages 2007
Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment Fulltext Access 11 Pages 2007
G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, in human epidermoid carcinoma A431 cells Fulltext Access 11 Pages 2007