Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor Fulltext Access 12 Pages 2006
A double-blind, randomized trial to evaluate the pharmacokinetics and tolerability of 30 or 40 mg/d oral olanzapine relative to 20 mg/d oral olanzapine in stable psychiatric subjects 5 Fulltext Access 12 Pages 2006
Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels * Fulltext Access 12 Pages 2006
Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: The VESIcare open-label trial (VOLT) Fulltext Access 12 Pages 2006
Early mortality in taiwanese lamivudine-treated patients with chronic hepatitis B-related decompensation: evaluation of the model for end-stage liver disease and index scoring systems as prognostic predictors Fulltext Access 12 Pages 2006
A twelve-week, multicenter, randomized, double-blind, parallel-group, noninferiority trial of the antihypertensive efficacy and tolerability of imidapril and candesartan in adult patients with mild to moderate essential hypertension: The Iberian Multicent Fulltext Access 12 Pages 2006
A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years * Fulltext Access 12 Pages 2006
Onset of action of fexofenadine hydrochloride 60 mg/ pseudoephedrine hydrochloride 120 mg in subjects aged ⩾ 12 years with moderate to severe seasonal allergic Rhinitis: A pooled analysis of two single-dose, randomized, double-blind, placebo-controlled al Fulltext Access 12 Pages 2006
Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: A 29-day, multicenter, open-Label, dose-escalation study Fulltext Access 12 Pages 2006
Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients Fulltext Access 12 Pages 2006
Effects of low-dose norethindrone acetate plus ethinyl estradiol (0.5 mg/2.5 μg) in women with postmenopausal symptoms: Updated analysis of three randomized, controlled trials Fulltext Access 12 Pages 2006
Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets Fulltext Access 12 Pages 2006
Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia–reperfusion Fulltext Access 12 Pages 2006
Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4 Fulltext Access 12 Pages 2006
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury Fulltext Access 12 Pages 2006
Selective lysis of erythrocytes infected with the trophozoite stage of Plasmodium falciparum by polyene macrolide antibiotics Fulltext Access 12 Pages 2006
The forgotten Gram-negative bacilli: What genetic determinants are telling us about the spread of antibiotic resistance Fulltext Access 12 Pages 2006
Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer Fulltext Access 12 Pages 2006
Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells Fulltext Access 12 Pages 2006
In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells Fulltext Access 12 Pages 2006
PPARγ agonist induced cardiac enlargement is associated with reduced fatty acid and increased glucose utilization in myocardium of Wistar rats Fulltext Access 12 Pages 2006
Nerve growth factor: The central hub in the development of allergic asthma? Fulltext Access 12 Pages 2006
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases Fulltext Access 12 Pages 2006
Noradrenaline-induced increases in calcium and tension in skeletal muscle conductance and resistance arteries from rats with post-infarction heart failure Fulltext Access 12 Pages 2006
Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine Fulltext Access 12 Pages 2006
Regulatory properties of adenylate cyclases type 5 and 6: A progress report Fulltext Access 12 Pages 2006
The phyto-chemical (−)-epigallocatechin gallate suppresses gene expression of epidermal growth factor receptor in rat hepatic stellate cells in vitro by reducing the activity of Egr-1 Fulltext Access 12 Pages 2006
Transcriptional changes facilitate mitotic catastrophe in tumour cells that contain functional p53 Fulltext Access 12 Pages 2006
Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics Fulltext Access 12 Pages 2006
Inhibition of nuclear factor κB is associated with neuroprotective effects of glycyrrhizic acid on glutamate-induced excitotoxicity in primary neurons Fulltext Access 12 Pages 2006
Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents Fulltext Access 12 Pages 2006
Lymphatic regeneration across an incisional wound: Inhibition by dexamethasone and aspirin, and acceleration by a micronized purified flavonoid fraction Fulltext Access 12 Pages 2006
Involvement of adenosinergic receptor system in an animal model of tardive dyskinesia and associated behavioural, biochemical and neurochemical changes Fulltext Access 12 Pages 2006
Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi Fulltext Access 12 Pages 2006
Drugs and falls in community-dwelling older people: a national veterans study Fulltext Access 12 Pages 2006
Proposed dose equivalence for rapid switch between dopamine receptor agonists in Parkinson's disease: A review of the literature Fulltext Access 12 Pages 2006
Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1 Fulltext Access 12 Pages 2006
Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity Fulltext Access 12 Pages 2006
Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells Fulltext Access 12 Pages 2006
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses Fulltext Access 12 Pages 2006
Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen Fulltext Access 12 Pages 2006
DNA immunization with 2C FMDV non-structural protein reveals the presence of an immunodominant CD8+, CTL epitope for Balb/c mice Fulltext Access 12 Pages 2006
CO from enhanced HO activity or from CORM-2 inhibits both O2− and NO production and downregulates HO-1 expression in LPS-stimulated macrophages Fulltext Access 12 Pages 2006
Three-dimensional culture models for human viral diseases and antiviral drug development Fulltext Access 12 Pages 2006
Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Fulltext Access 12 Pages 2006
Modulation of cadmium induced alterations in murine thymocytes by piperine: Oxidative stress, apoptosis, phenotyping and blastogenesis Fulltext Access 12 Pages 2006
Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes Fulltext Access 12 Pages 2006
Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity Fulltext Access 12 Pages 2006
Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells Fulltext Access 12 Pages 2006
Effective attenuation of acute lung injury in vivo and the formyl peptide-induced neutrophil activation in vitro by CYL-26z through the phosphoinositide 3-kinase γ pathway Fulltext Access 12 Pages 2006
Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure–activity relationship Fulltext Access 12 Pages 2006
Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions Fulltext Access 12 Pages 2006
Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death Fulltext Access 12 Pages 2006
The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity Fulltext Access 12 Pages 2006
TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin Fulltext Access 13 Pages 2006
Pharmacological characterization of recombinant N-type calcium channel (Cav2.2) mediated calcium mobilization using FLIPR Fulltext Access 13 Pages 2006
Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism Fulltext Access 13 Pages 2006
Recognition forces in ligand–protein complexes: Blending information from different sources Fulltext Access 13 Pages 2006
15-Deoxy-Δ12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors Fulltext Access 13 Pages 2006
Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells Fulltext Access 13 Pages 2006
Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma Fulltext Access 13 Pages 2006
Impact of depression on utilization patterns of oral hypoglycemic agents in patients newly diagnosed with type 2 diabetes mellitus: A retrospective cohort analysis * Fulltext Access 13 Pages 2006
Effects of cilomilast, a selective phosphodiesterase 4 inhibitor, on esophageal motility and ph, and orocecal and colonic transit: Two single-center, randomized, double-blind, placebo-controlled, two-part crossover studies in healthy volunteers Fulltext Access 13 Pages 2006
The decision-making process of us food and drug administration advisory committees on switches from prescription to over-the-counter status: A comparative case study Fulltext Access 13 Pages 2006
Intervention strategies for neonatal hypoxic-ischemic cerebral injury * Fulltext Access 13 Pages 2006
Use of sibutramine in obese mexican adolescents: A 6-month, randomized, double-blind, placebo-controlled, parallel-group trial Fulltext Access 13 Pages 2006
Pharmacologic characteristics and adrenal suppression with newer inhaled corticosteroids: A comparison of ciclesonide and fluticasone propionate Fulltext Access 13 Pages 2006
Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases Fulltext Access 13 Pages 2006
A 2-week, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase III trial comparing the efficacy of oxymorphone extended release and placebo in adults with pain associated with osteoarthritis of the hip or knee Fulltext Access 13 Pages 2006
Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal Fulltext Access 13 Pages 2006
N-(4-Trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion Fulltext Access 13 Pages 2006
Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly Controlled Type 2 Diabetes Fulltext Access 13 Pages 2006
Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: A Canadian perspective Fulltext Access 13 Pages 2006
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study ‡ Fulltext Access 13 Pages 2006
A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination Fulltext Access 13 Pages 2006
Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase Fulltext Access 13 Pages 2006
Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists Fulltext Access 13 Pages 2006
A comparison of measured trough levels and abbreviated AUC estimation by limited sampling strategies for monitoring mycophenolic acid exposure in stable heart transplant patients receiving cyclosporin A—Containing and cyclosporin A—Free immunosuppressive Fulltext Access 13 Pages 2006
Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives Fulltext Access 13 Pages 2006
Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells Fulltext Access 13 Pages 2006
Treatment of lower urinary tract symptoms in benign prostatic hyperplasia and its impact on sexual function Fulltext Access 13 Pages 2006
Efficacy and tolerability of fluticasone propionate/salmeterol administered twice daily via hydrofluoroalkane 134a metered-dose inhaler in adolescent and adult patients with persistent asthma: a randomized, double-blind, placebo-controlled, 12-week study Fulltext Access 13 Pages 2006
Multicenter, open-label, prospective evaluation of the conversion from previous opioid analgesics to extended-release hydromorphone hydrochloride administered every 24 hours to patients with persistent moderate to severe pain Fulltext Access 13 Pages 2006
Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: Results of two randomized, double-blind, placebo-controlled, single-dose studies Fulltext Access 13 Pages 2006