Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells Fulltext Access 9 Pages 2005
Chronic Î9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering Protein Kinase A activity in mouse brain and spinal cord Fulltext Access 9 Pages 2005
Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents Fulltext Access 9 Pages 2005
Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition Fulltext Access 9 Pages 2005
Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness Fulltext Access 9 Pages 2005
Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor Fulltext Access 9 Pages 2005
Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPARγ Fulltext Access 9 Pages 2005
Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes Fulltext Access 9 Pages 2005
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages Fulltext Access 9 Pages 2005
Mechanism of action of a novel “combi-triazene” engineered to possess a polar functional group on the alkylating moiety: Evidence for enhancement of potency Fulltext Access 9 Pages 2005
The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent Fulltext Access 9 Pages 2005
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model Fulltext Access 9 Pages 2005
Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism Fulltext Access 9 Pages 2005
Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells Fulltext Access 9 Pages 2005
Primaquine synergises the activity of chloroquine against chloroquine-resistant P. falciparum Fulltext Access 9 Pages 2005
Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53 Fulltext Access 9 Pages 2005
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells Fulltext Access 9 Pages 2005
Effect of an oversulfated exopolysaccharide on angiogenesis induced by fibroblast growth factor-2 or vascular endothelial growth factor in vitro Fulltext Access 9 Pages 2005
Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5 Fulltext Access 9 Pages 2005
Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A Fulltext Access 9 Pages 2005
Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages Fulltext Access 9 Pages 2005
Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure-activity relationship and molecular-modeling studies Fulltext Access 9 Pages 2005
Protective effect of FK506 against apoptosis of SH-SY5Y cells correlates with regulation of the serum inducible kinase gene Fulltext Access 9 Pages 2005
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2 Fulltext Access 9 Pages 2005
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NFκB ligand (RANKL) or tumor necrosis factor-α (TNF-α) Fulltext Access 9 Pages 2005
Synthesis and biological activities of bisnaphthalimido polyamines derivatives: cytotoxicity, DNA binding, DNA damage and drug localization in breast cancer MCF 7 cells Fulltext Access 9 Pages 2005
Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid Fulltext Access 9 Pages 2005
Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides Fulltext Access 9 Pages 2005
l-Arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide Fulltext Access 9 Pages 2005
Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis Fulltext Access 9 Pages 2005
Spin adduct formation from lipophilic EMPO-derived spin traps with various oxygen- and carbon-centered radicals Fulltext Access 9 Pages 2005
Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells Fulltext Access 9 Pages 2005
Impaired activation of caspases and prevention of mitochondrial dysfunction in the metastatic colon carcinoma CC531s-m2 cell line Fulltext Access 9 Pages 2005
Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines Fulltext Access 9 Pages 2005
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress Fulltext Access 9 Pages 2005
Curcumin-induced histone hypoacetylation: The role of reactive oxygen species Fulltext Access 9 Pages 2005
Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design Fulltext Access 9 Pages 2005
Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells Fulltext Access 9 Pages 2005
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives Fulltext Access 9 Pages 2005
Morin inhibits 12-O-tetradecanoylphorbol-13-acetate-induced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression Fulltext Access 9 Pages 2005
Inositol 1,4,5-triphosphate-mediated shuttling between intracellular stores and the cytosol contributes to the sustained elevation in cytosolic calcium in FMLP-activated human neutrophils Fulltext Access 9 Pages 2005
A sensitive new method for clinically monitoring cytarabine concentrations at the DNA level in leukemic cells Fulltext Access 9 Pages 2005
Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: Role of the farnesoid X receptor Fulltext Access 9 Pages 2005
Differential CB1 and CB2 cannabinoid receptor-inotropic response of rat isolated atria: Endogenous signal transduction pathways Fulltext Access 9 Pages 2005
Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels Fulltext Access 9 Pages 2005
Validation of a colorimetric assay for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE) from plant extracts Fulltext Access 9 Pages 2005
Signal transduction underlying carbachol-induced PGE2 generation and cox-1 mRNA expression of rat brain Fulltext Access 9 Pages 2005
Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism Fulltext Access 9 Pages 2005
Diclofenac, a nonsteroidal anti-inflammatory drug, activates the transient outward K+ current in rat cerebellar granule cells Fulltext Access 9 Pages 2005
Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain Fulltext Access 9 Pages 2005
Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice Fulltext Access 9 Pages 2005
Pharmacological reactivity to cocaine in adult rats undernourished at perinatal age: behavioral and neurochemical correlates Fulltext Access 9 Pages 2005
Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats Fulltext Access 9 Pages 2005
Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity Fulltext Access 9 Pages 2005
Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: Implications for treating Parkinson's disease? Fulltext Access 9 Pages 2005
Pharmacological and histological characterisation of nicotine-kindled seizures in mice Fulltext Access 9 Pages 2005
GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus Fulltext Access 9 Pages 2005
A 1-year follow-up after a pilot study with Doloteffin® for low back pain Fulltext Access 9 Pages 2005
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment Fulltext Access 9 Pages 2005
Autoradiographic characterisation of [35S]GTPγS binding stimulation mediated by 5-HT1B receptor in postmortem human brain Fulltext Access 9 Pages 2005
Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures Fulltext Access 9 Pages 2005
Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Fulltext Access 9 Pages 2005
Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice Fulltext Access 9 Pages 2005
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats Fulltext Access 9 Pages 2005
Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity Fulltext Access 9 Pages 2005
Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures Fulltext Access 9 Pages 2005
Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development Fulltext Access 9 Pages 2005
Transport of transforming growth factor-β2 across the blood-brain barrier Fulltext Access 9 Pages 2005
CpG-DNA protects against a lethal orthopoxvirus infection in a murine model Fulltext Access 9 Pages 2005
Serum thymic factor, FTS, attenuates cisplatin nephrotoxicity by suppressing cisplatin-induced ERK activation Fulltext Access 9 Pages 2005
Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells Fulltext Access 9 Pages 2005
The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands Fulltext Access 9 Pages 2005
Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors Fulltext Access 9 Pages 2005
Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat Fulltext Access 9 Pages 2005
Hypoxia impedes the formation of chromium DNA-adducts in a cell-free system Fulltext Access 9 Pages 2005
Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation Fulltext Access 9 Pages 2005
IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence Fulltext Access 9 Pages 2005
The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs Fulltext Access 9 Pages 2005
Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Fulltext Access 9 Pages 2005
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis Fulltext Access 9 Pages 2005
Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity Fulltext Access 9 Pages 2005
Neonatal toluene exposure alters N-methyl-d-aspartate receptor subunit expression in the hippocampus and cerebellum in juvenile rats Fulltext Access 9 Pages 2005
Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir Fulltext Access 9 Pages 2005
Antiviral efficacy of VP14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol Fulltext Access 9 Pages 2005
Antiviral activity and mode of action of caffeoylquinic acids from Schefflera heptaphylla (L.) Frodin Fulltext Access 9 Pages 2005
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an “in vitro” replicative system Fulltext Access 9 Pages 2005
Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-κB pathway Fulltext Access 9 Pages 2005
Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro Fulltext Access 9 Pages 2005
Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice Fulltext Access 9 Pages 2005
Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements Fulltext Access 9 Pages 2005