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Pharmacology Research Articles

Tyrosine kinase-mediated activation of NAD(P)H oxidase enhances proliferative capacity of diabetic vascular smooth muscle cells
Fulltext Access 11 Pages 2005
Endomorphin 1[ψ] and endomorphin 2[ψ], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception
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Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities
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Protective effects of intracellular reactive oxygen species generated by 6-formylpterin on tumor necrosis factor-α-induced apoptotic cell injury in cultured rat hepatocytes
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PPAR-γ: A nuclear receptor with affinity for cannabinoids
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Lipid rafts: A nexus for endocannabinoid signaling?
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Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia
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Potential hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice
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α-Adrenergic and muscarinic cholinergic receptors are not involved in the modulation of the parasympathetic baroreflex by the medial prefrontal cortex in rats
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Multiple calmodulin mRNAs are selectively transported to functionally different neuronal and glial compartments in the rat hippocampus. An electron microscopic in situ hybridization study
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Adrenergic response patterns in vas deferens isolated from rats under diurnal rhythms
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A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete areas of rat brain
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Functional and pharmacological mechanisms of nucleoside transport across the basolateral membrane of rabbit tracheal epithelial cells
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Drug discovery from medicinal plants
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Neutrophils activation can be diminished by apolipoprotein A-I
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Marked increase in the histamine content of neointima after stent implantation of pig coronary artery and growth-promoting effects of histamine in cultured smooth muscle cells
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Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100®
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Heme oxygenase as a therapeutic target in immunological pregnancy complications
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Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-α
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Modulation of acute inflammation by targeting glycosaminoglycan-cytokine interactions
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Chemically modified tetracyclines induce apoptosis in cultured mast cells
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Proteinase activity and stability of natural bromelain preparations
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Suppression of CD4+ T cell activation by a novel inhibitor of Src family kinases
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Biochemical effects of KH 1060 and anti-TNF monoclonal antibody on human peripheral blood mononuclear cells
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Melanin: dietary mucosal immune modulator from Echinacea and other botanical supplements
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Comparative effect of seeds of Rhynchosia volubilis and soybean on MG-63 human osteoblastic cell proliferation and estrogenicity
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Effect of p-chloroamphetamine on calcium movement and viability in renal tubular cells
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A fungal tRNA of Aspergillus niger induces IFN-β synthesis in HEp-2 cells
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Cloning and establishment of a line of rats for high levels of voluntary wheel running
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Melanin counter act puromycin-induced inhibition of collagen and DNA biosynthesis in human skin fibroblasts
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Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes
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Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/reoxygenation injury
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Enamel matrix derivative is a potent inhibitor of breast cancer cell attachment to bone
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Identification of 4-methylspinaceamine - a Pictet - Spengler condensation reaction product of histamine with acetaldehyde - in human urine
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Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice
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Modulation of α4 integrin mRNA levels is coupled to deficits in vasomotor function in rat arterioles by allylamine
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Increase of Bax/ Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line
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Early altered renal sodium handling determined by lithium clearance in spontaneously hypertensive rats (SHR): Role of renal nerves
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Dermatan disulfate (Intimatan) prevents complement-mediated myocardial injury in the human-plasma-perfused rabbit heart
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Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis
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Relaxation of canine corporal smooth muscle relaxation by ginsenoside saponin Rg3 is independent from eNOS activation
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Inhibition of hypoxia-induced proliferation and collagen synthesis by vasonatrin peptide in cultured rat pulmonary artery smooth muscle cells
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Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice
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Anti-obese action of raspberry ketone
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Oxidative stress in heroin administered mice and natural antioxidants protection
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Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes
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Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes
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Comparison of short-term toxicity between Nano-Se and selenite in mice
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Lanthanide-based luminescent assays for ligand-receptor interactions
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Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: Affinity for neuronal nicotinic acetylcholine receptors
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NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin
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Oral administration of paclitaxel affects the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats
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Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans
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CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats
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Gene - environment interactions determine the individual variability in cocaine self-administration
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The modulation of Ca2+ and K+ channels but not changes in cAMP signaling contribute to the inhibition of glutamate release by cannabinoid receptors in cerebrocortical nerve terminals
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Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
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Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores
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Time-dependent effects of repeated cocaine administration on dopamine transmission in the medial prefrontal cortex
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Anxiolytic activity of progesterone in progesterone receptor knockout mice
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Acetylcholine receptor effects on accumbal shell dopamine-mediated turning behaviour in rats
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Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats
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Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis
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The relationship of guideline-concordant depression treatment and patient adherence to oral diabetes medications
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A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses
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Differential regulation of serotonin (5HT)2A receptor mRNA and protein levels after single and repeated stress in rat brain: role in learned helplessness behavior
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Developmentally regulated expression of VGLUT3 during early post-natal life
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Selective cortical VGLUT1 increase as a marker for antidepressant activity
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Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1
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Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval
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A serine proteinase inhibitor isolated from Tamarindus indica seeds and its effects on the release of human neutrophil elastase
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Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach
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Mechanisms of oleic acid deterioration in insulin secretion: Role in the pathogenesis of type 2 diabetes
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Evaluation of the cytotoxicity, cytostaticity and genotoxicity of Argentatins A and B from Parthenium argentatum (Gray)
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Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells
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A fetal sheep liver extract containing immunostimulatory substances including LPS acts as leukocyte activator in cells of LPS responder and non responder mice
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COX expression and PGE2 and PGD2 production in experimental acute and chronic gastric lesions
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Liposomal methylprednisolone differentially regulates the expression of TNF and IL-10 in human alveolar macrophages
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
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Opposing effect of IFNγ and IFNα on expression of NKG2 receptors: Negative regulation of IFNγ on NK cells
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Effects of mycophenolic acid on endothelial cells
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The screening and isolation of an effective anti-endotoxin monomer from Radix Paeoniae Rubra using affinity biosensor technology
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Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice
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Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and matrix metalloproteinase activity
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Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: Inverse agonism exhibited by the receptor antagonists
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Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657
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Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism
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Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine model
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RETRACTED: Expression of matrix metalloproteinase-26 (MMP-26) mRNA in mouse uterus during the estrous cycle and early pregnancy
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Neurobiology of craving, conditioned reward and relapse
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β-lactams against methicillin-resistant Staphylococcus aureus
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The long-term cost-effectiveness of clopidogrel plus aspirin in patients undergoing percutaneous coronary intervention in Sweden
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Tigecycline: An investigational glycylcycline antimicrobialwith activity against resistant gram-positive organisms
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The bone quality framework: Determinants of bone strength and their interrelationships, and implications for osteoporosis management
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Beta-interferon and interleukin-2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: an exploratory trial
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Physiological, pharmacological and clinical features of the multidrug resistance protein 2
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Prokaryotic and eukaryotic unicellular chronomics
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Why continued surveillance? Intermittent blood pressure and heart rate abnormality under treatment
Fulltext Access 11 Pages 2005
Prevention of HIV-1 infection by platinum triazines
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Human cytomegalovirus-inhibitory flavonoids: Studies on antiviral activity and mechanism of action
Fulltext Access 11 Pages 2005
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