Cell apoptosis induced by a synthetic carbazole compound LCY-2-CHO is mediated through activation of caspase and mitochondrial pathways Fulltext Access 11 Pages 2005
BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death Fulltext Access 11 Pages 2005
Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration Fulltext Access 11 Pages 2005
Sodium nitroprusside-induced osteoblast apoptosis is mediated by long chain ceramide and is decreased by raloxifene Fulltext Access 11 Pages 2005
Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression Fulltext Access 11 Pages 2005
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation Fulltext Access 11 Pages 2005
Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas Fulltext Access 11 Pages 2005
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro Fulltext Access 11 Pages 2005
Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma Fulltext Access 11 Pages 2005
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium Fulltext Access 11 Pages 2005
Aspirin Compared with Acetaminophen in the Treatment of Feverand OtherSymptoms of Upper Respiratory Tract Infection in Adults: A Multicenter, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Parallel-Group, Single-Dose, 6-Hour Dose-Ranging Stud Fulltext Access 11 Pages 2005
A synthesized cationic tetradecapeptide from hornet venom kills bacteria and neutralizes lipopolysaccharide in vivo and in vitro Fulltext Access 11 Pages 2005
Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells Fulltext Access 11 Pages 2005
Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway Fulltext Access 11 Pages 2005
Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes Fulltext Access 11 Pages 2005
Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain Fulltext Access 11 Pages 2005
6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages Fulltext Access 11 Pages 2005
Role of cytosolic phospholipase A2 in the enhancement of α2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: Comparison with vasopressin-enhanced responses Fulltext Access 11 Pages 2005
Induction of apoptotic cell death by 2â²-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells Fulltext Access 11 Pages 2005
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency Fulltext Access 11 Pages 2005
6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities Fulltext Access 11 Pages 2005
Efficacy and tolerability of the switch from a branded to a generic garfarin sodium product: an observer-blinded, randomized, crossover study Fulltext Access 11 Pages 2005
Retrospective study of the costs of care during the first year of therapy with etanercept or infliximab among patients aged â¥65 years with rheumatoid arthritis Fulltext Access 11 Pages 2005
Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: The VAST study Fulltext Access 11 Pages 2005
Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis Fulltext Access 11 Pages 2005
Treating diabetes to accepted standards of care: A 10-year projection of the estimated economic and health impact in patients with type 1 and type 2 diabetes mellitus in the United States Fulltext Access 11 Pages 2005
A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit Fulltext Access 11 Pages 2005
Cetuximab: An epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer Fulltext Access 11 Pages 2005
A cost-effectiveness analysis of fluvastatin in patients with diabetes after successful percutaneous coronary intervention Fulltext Access 11 Pages 2005
Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: A 30-day, randomized, double-masked, artificial tear substitute-controlled trial Fulltext Access 11 Pages 2005
Advantages of new cardiovascular risk-assessment strategies in high-risk patients with hypertension Fulltext Access 11 Pages 2005
Economic evaluation of a randomized trial comparinghelicobacter pylori test-and-treat and prompt endoscopy strategies for managing dyspepsia in a primary-care setting Fulltext Access 11 Pages 2005
Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: A single-center, multiple-dose, open-label study Fulltext Access 11 Pages 2005
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury Fulltext Access 11 Pages 2005
Use of Monte Carlo simulation to assess the pharmacodynamics of β-lactams against pseudomonas aeruginosa infections in children: A report from the OPTAMA program Fulltext Access 11 Pages 2005
Comparison of fixed-dose combinations of telmisartan/hydrochlorothiazide 40/12.5 mg and 80/12.5 mg and a fixed-dose combination of losartan/hydrochlorothiazide 50/12.5 mg in mild to moderate essential hypertension: Pooled analysis of two multicenter, pros Fulltext Access 11 Pages 2005
Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in Rural Chinese patients with essential hypertension Fulltext Access 11 Pages 2005
Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations Fulltext Access 11 Pages 2005
Efficacy and tolerability of controlled-release paroxetine in the treatment of severe depression: Post hoc analysis of pooled data from a subset of subjects in four double-blind clinical trials Fulltext Access 11 Pages 2005
Impact of an adherence clinic on behavioral outcomes and virologic response in treatment of HIV infection: A prospective, randomized, controlled pilot study Fulltext Access 11 Pages 2005
Long-term safety and, tolerability profiles andlipid-modifying efficacy of ezetimibe coadministered with ongoing simvastatin treatment: A multicenter, randomized, double-blind, placebo-controlled, 48-week extension study Fulltext Access 11 Pages 2005
A pharmacoeconomic evaluation of escitalopram versus citalopram in the treatment of severe depression in the United Kingdom Fulltext Access 11 Pages 2005
Analgesic effects of intranasal butorphanol tartrate administered via a unit-dose device in the dental impaction pain model: A randomized, double-blind, placebo-controlled, parallel-group study Fulltext Access 11 Pages 2005
Two replicate randomized, double-blind, placebo-controlled trials of the time to onset of pain relief in the acute treatment of migraine with a fast-disintegrating/rapid-release formulation of sumatriptan tablets Fulltext Access 11 Pages 2005
Simulation of Antibiotic Pharmacodynamic Exposure for the Empiric Treatment of Nosocomial Bloodstream Infections: A Report from the OPTAMA Program Fulltext Access 11 Pages 2005
Double-Coated Poly (Butylcynanoacrylate) Nanoparticulate Delivery Systems for Brain Targeting of Dalargin Via Oral Administration Fulltext Access 11 Pages 2005
Thermal and Fractal Analysis of Diclofenac/Gelucire 50/13 Microparticles Obtained by Ultrasound-Assisted Atomization Fulltext Access 11 Pages 2005
Drug Molecules as Probes for Studying the Compatibility Between Gels and Mucous Tissue with Dielectric Spectroscopy Fulltext Access 11 Pages 2005
Physicochemical and Structural Characterization of Quercetin-β-Cyclodextrin Complexes Fulltext Access 11 Pages 2005
A Novel Standard Sample Powder Preparation Method for Quantitative Analysis of Polymorphs Fulltext Access 11 Pages 2005
Physicochemical Characterization of Ricobendazole: I. Solubility, Lipophilicity, and Ionization Characteristics Fulltext Access 11 Pages 2005
Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state Fulltext Access 11 Pages 2005
Magnetic resonance profiling of human skin in vivo using GARField magnets Fulltext Access 11 Pages 2005
Effect of formulation factors on electroosmotic glucose transport through human skin in vivo Fulltext Access 11 Pages 2005
Development of a novel high-concentration galantamine formulation suitable for intranasal delivery Fulltext Access 11 Pages 2005
Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability Fulltext Access 11 Pages 2005
Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies Fulltext Access 11 Pages 2005
IPM/DOSS/water Microemulsions as Reactors for Silver Sulfadiazine Nanocrystal Synthesis Fulltext Access 11 Pages 2005
Low Molecular Weight Dextrans Stabilize Nonviral Vectors During Lyophilization at Low Osmolalities: Concentrating Suspensions by Rehydration to Reduced Volumes Fulltext Access 11 Pages 2005
The Study of In Vitro-In Vivo Correlation: Pharmacokinetics and Pharmacodynamics of Albuterol Dry Powder Inhalers Fulltext Access 11 Pages 2005
In-Line Monitoring of Hydrate Formation during Wet Granulation Using Raman Spectroscopy Fulltext Access 11 Pages 2005
Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders Fulltext Access 11 Pages 2005
Rheological and Dielectric Characterization of Monoolein/Water Mesophases in the Presence of a Peptide Drug Fulltext Access 11 Pages 2005
Electrostatic charge characteristics of aerosols produced from metered dose inhalers Fulltext Access 11 Pages 2005
Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: Assessment of nonlinearity of metoprolol, timolol, and propranolol Fulltext Access 11 Pages 2005
Comparison of Pharmacokinetics of Loxoprofen and its Active Metabolites After an Intravenous, Intramuscular, and Oral Administration of Loxoprofen in Rats: Evidence for Extrahepatic Metabolism Fulltext Access 11 Pages 2005
Very stable superoxide radical adducts of 5-ethoxycarbonyl- 3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives Fulltext Access 11 Pages 2005
(+)- And (â)-borneol: efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABAA receptors Fulltext Access 11 Pages 2005
Cloning and pharmacological characterization of the cat urotensin-II receptor (UT) Fulltext Access 11 Pages 2005
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease Fulltext Access 11 Pages 2005
Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells Fulltext Access 11 Pages 2005
Evaluation of the neuronal apoptotic pathways involved in cytoskeletal disruption-induced apoptosis Fulltext Access 11 Pages 2005
Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons Fulltext Access 11 Pages 2005
EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer Fulltext Access 11 Pages 2005
Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension Fulltext Access 11 Pages 2005
Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes Fulltext Access 11 Pages 2005
Role of mechanical and redox stress in activation of mitogen-activated protein kinases in primary cultured rat hepatocytes Fulltext Access 11 Pages 2005
Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: Time course and influence of nicotine dosing regimen Fulltext Access 11 Pages 2005
The role of NMDA receptor upregulation in phencyclidine-induced cortical apoptosis in organotypic culture Fulltext Access 11 Pages 2005
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ibuprofen* Fulltext Access 11 Pages 2005
Inhibitory effect of DA-125, a new anthracyclin analog antitumor agent, on the invasion of human fibrosarcoma cells by down-regulating the matrix metalloproteinases Fulltext Access 11 Pages 2005
Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors Fulltext Access 11 Pages 2005
Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment Fulltext Access 11 Pages 2005
Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues Fulltext Access 11 Pages 2005
Effect of a selective GABAB receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects Fulltext Access 11 Pages 2005
Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain Fulltext Access 11 Pages 2005
Neurosteroid pregnenolone sulfate inhibits stimulus-evoked EPSC via presynaptic inhibition of protein kinase A in rat prelimbic cortical neurons Fulltext Access 11 Pages 2005
NMDA enhances a depolarization-activated inward current in subthalamic neurons Fulltext Access 11 Pages 2005
Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent Fulltext Access 11 Pages 2005
Fluconazole Distribution in Rat Dermis Following Intravenous and Topical Application: A Microdialysis Study Fulltext Access 11 Pages 2005
Tuning the Polymer Release from Hydrophilic Matrix Tablets by Mixing Short and Long Matrix Polymers Fulltext Access 11 Pages 2005