کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10158830 | 1666546 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study on effects of steroid on clinical course, short-term and long-term outcomes in neonates with meconium aspiration syndrome
ترجمه فارسی عنوان
بررسی اثرات استروئید بر روی دوره بالینی، نتایج کوتاه مدت و بلند مدت نوزادان مبتلا به سندرم آسپیراسیون مکونیم
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کلمات کلیدی
سندرم آسپیراسیون مکونیم، استروئیدها، نوزادان، نتیجه کوتاه مدت، نتیجه درازمدت،
موضوعات مرتبط
علوم پزشکی و سلامت
پرستاری و مشاغل بهداشتی
مامایی
چکیده انگلیسی
The definite role of steroids in meconium aspiration syndrome (MAS), their safety and short-term as well as long-term outcomes are yet to be evaluated in large clinical trials; although some recent studies have yielded encouraging results. A randomized controlled trial was conducted over three years involving 275 neonates, where one group (nâ¯=â¯137) received intravenous (IV) methylprednisolone and nebulized budesonide along with the conventional management (IV normal saline and nebulized 3% saline), and the other group (nâ¯=â¯138) received conventional management only. These infants were followed up at 1, 3, and 6 months after discharge. We noticed a remarkable and statistically significant improvement in the clinical course including reduction in the Downes' score, oxygen dependency, the need of mechanical ventilation, and respiratory distress as well as a reduction in long-term complications including bronchopulmonary dysplasia, cerebral palsy etc.; in neonates receiving IV and nebulized steroid. We also did not observe any increased rate of sepsis, hypoglycemia, necrotizing enterocolitis in this group.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neonatal Nursing - Volume 24, Issue 5, October 2018, Pages 257-260
Journal: Journal of Neonatal Nursing - Volume 24, Issue 5, October 2018, Pages 257-260
نویسندگان
Kriti Sundar Rana, Mithun Chandra Konar, Kamirul Islam, Kanai Lal Barik, Kaustav Nayek, Asok Kumar Datta,