کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10215599 | 1678892 | 2019 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance
ترجمه فارسی عنوان
تحریک جریان متناوب با فرکانس پایین موجب کاهش نوسانات باند گاما می شود و عملکرد ادراکی را مختل می کند
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Low frequency oscillations such as alpha (8-12Â Hz) are hypothesized to rhythmically gate sensory processing, reflected by 40-100Â Hz gamma band activity, via the mechanism of pulsed inhibition. We applied transcranial alternating current stimulation (TACS) at individual alpha frequency (IAF) and flanking frequencies (IAF-4 Hz, IAF+4Â Hz) to the occipital cortex of healthy human volunteers during concurrent magnetoencephalography (MEG), while participants performed a visual detection task inducing strong gamma-band responses. Occipital (but not retinal) TACS phasically suppressed stimulus-induced gamma oscillations in the visual cortex and impaired target detection, with stronger phase-to-amplitude coupling predicting behavioral impairments. Retinal control TACS ruled out retino-thalamo-cortical entrainment resulting from (subthreshold) retinal stimulation. All TACS frequencies tested were effective, suggesting that visual gamma-band responses can be modulated by a range of low frequency oscillations. We propose that TACS-induced membrane potential modulations mimic the rhythmic change in cortical excitability by which spontaneous low frequency oscillations may eventually exert their impact when gating sensory processing via pulsed inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 184, 1 January 2019, Pages 440-449
Journal: NeuroImage - Volume 184, 1 January 2019, Pages 440-449
نویسندگان
Jim D. Herring, Sophie Esterer, Tom R. Marshall, Ole Jensen, Til O. Bergmann,