کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10224977 | 1701146 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subclassification of hepatocellular adenomas: practical considerations in the implementation of the Bordeaux criteria
ترجمه فارسی عنوان
طبقه بندی آدنوم های خونی: ملاحظات عملی در اجرای معیارهای بوردو
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کلمات کلیدی
نئوپلاسم های کبدی، آدنوم سلول کبدی، آدنوم خونسردی ایمونوهیستوشیمی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی قانونی
چکیده انگلیسی
Hepatocellular adenomas are benign liver lesions with a risk of rupture and malignant transformation. Various molecular subgroups have been identified which appear to have characteristic morphological and immunohistochemical features. We examined the morphology and immunohistochemical profile of a series of 121 HCA from 97 patients to identify the HCA subtypes present and determine the number at risk for malignant transformation according to the World Health Organization (WHO) criteria for hepatocellular adenomas. There were 34 HNF1α inactivated HCA (28%), 61 inflammatory HCA (50%), 15 β-catenin activated HCA (12%) and 11 unclassified adenomas (9%). This proportion of cases was similar to that seen in other series utilising molecular classification. The morphological features of the adenomas were suggestive but not definite indicators of the subtypes present. Morphological features that showed overlap between the subtypes included steatosis within the lesion, a ductular reaction and focal atypia, so that immunohistochemical typing was required for accurate classification. In conclusion, immunohistochemistry is a clinically useful surrogate for identifying underlying molecular changes in the HCA subtypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 50, Issue 6, October 2018, Pages 593-599
Journal: Pathology - Volume 50, Issue 6, October 2018, Pages 593-599
نویسندگان
Gregory C. Miller, Catherine M. Campbell, Bavahuna Manoharan, Richard Bryant, David Cavallucci, Nicholas O'Rourke, Andrew D. Clouston,