کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10276275 | 463423 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molybdenocene-DNA interaction studies using electrochemical analysis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The binding interactions of molybdenocene dichloride (Cp2MoCl2) and [Cp2Mo(L)n]Cl2 (n = 1, L = 6-mercaptopurine, 6-mercaptopurineribose, 2-amine-6-mercaptopurine and 2-amine-6-mercaptopurineribose and n = 2, L = d-penicillamine) complexes with calf-thymus DNA have been investigated by cyclic voltammetry. Cp2MoCl2 belongs to a group of metallocene antitumor agents and [Cp2Mo(L)n]Cl2 complexes are structural modifications of molybdenocene dichloride that have also been shown to possess antitumor properties. From the mechanistic point, there is interest in discovering whether molybdenocene dichloride binds DNA or not. To investigate this issue in more detail, we carried out molybdenocene-DNA titrations monitored by cyclic voltammetry. The changes in oxidation potentials (Epa) allowed us to determine the degree of Mo-DNA interaction. (Cp2MoCl2) and [Cp2Mo(L)n]Cl2 (n = 1, L = 2-amine-6-mercaptopurine and 2-amine-6-mercaptopurineribose and n = 2, L = d-penicillamine) complexes showed weak DNA bindings (3.2-10.1%) while the complexes containing the ligands 6-mercaptopurine and 6-mercaptopurineribose showed negligible interactions. ICP-AES was used to corroborate the CV results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 576, Issue 2, 1 March 2005, Pages 315-322
Journal: Journal of Electroanalytical Chemistry - Volume 576, Issue 2, 1 March 2005, Pages 315-322
نویسندگان
MarıÌa I. RodrıÌguez, Tulio Chávez-Gil, Yasiris Colón, Naomi DıÌaz, Enrique Meléndez,