کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10374994 | 880025 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On the incorporation of the non-steroidal anti-inflammatory naproxen into cationic O/W microemulsions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
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چکیده انگلیسی
Microemulsions (ME) containing hexadecyltrimethylammonium bromide (HTAB)/ethanol as surfactant, isopropylmyristate (IM) or butylstearate (BS) as oil phase and aqueous buffer were studied. Pseudo-ternary phase diagrams of the investigated systems were obtained at constant surfactant/cosurfactant molar ratio (1:5) by titration in order to characterize the proportions between the components to obtain clear systems. Oil in water microemulsions were prepared in a wide range of phase volume (Ï). UV-vis absorption spectra of naproxen at pH 5.5 showed that the solubility of Np increases significantly in the presence of O/W ME in high phase volumes. For both, IM and BS microemulsions, the dynamic light scattering experiments showed that the size of the oil droplets remains constant in low values of Ï, increasing abruptly in high Ï values. Phase solubility study revealed that for both IM and BS microemulsions, the drug incorporation followed a straight-line profile in all range of Ï. The data could be analyzed through the phase-separation model and the association constants (K) calculated varied from 27 to 90Â Mâ1, depending on the pH and on the microemulsion oil phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 43, Issue 2, 25 June 2005, Pages 108-114
Journal: Colloids and Surfaces B: Biointerfaces - Volume 43, Issue 2, 25 June 2005, Pages 108-114
نویسندگان
M.A. Correa, M.V. Scarpa, M.C. Franzini, A.G. Oliveira,