کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10451525 | 918466 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The efficacy of intravenous acetaminophen (1000Â mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to the International Headache Society Classification. Sixty patients were included in three headache outpatient centers (Neurology Departments of the Universities of Regensburg, Münster and München). In the acute migraine attack patients were treated intravenously with either 1000Â mg paracetamol (acetaminophen) or placebo. The primary end point was pain-free after 2Â h. Secondary efficacy criteria were pain-free after 24Â h or pain relief after 2Â hours and after 24Â hours. With regard to the efficacy criteria, 37% of patients reported pain relief or painfree after two hours, 12 patients after treatment with acetaminophen and 10 patients after treatment with placebo. Out of these, 3 patients in the acetaminophen and 4 patients in the placebo group were painfree. After 24Â hours 86% of the patients reported pain relief: 24 treated with acetaminophen and 27 treated with placebo. The results indicate, that 1000Â mg intravenous acetaminophen is not superior to placebo in treating severe acute migraine attacks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pain - Volume 117, Issue 3, October 2005, Pages 396-400
Journal: Pain - Volume 117, Issue 3, October 2005, Pages 396-400
نویسندگان
Elke Leinisch, Stefan Evers, Nina Kaempfe, Christoffer Kraemer, Petra Sostak, Tim Jürgens, Andreas Straube, Arne May,