Functional neuroimaging studies in addiction: Multisensory drug stimuli and neural cue reactivity

► Review of 44 whole-brain functional neuroimaging addiction cue reactivity studies. ► Comparison of neural cue reactivity for multisensory and unisensory drug cues. ► Preference for multisensory cues in the motor cortex, PCC and insula. ► More consistent correlations with clinical covariates in these regions. ► Treatment and research can benefit from employing multisensory drug cues.