Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence

► CeA mediates alcohol-related behaviors and chronic alcohol-induced plasticity. ► Pro-stress and anti-stress peptides alter GABAergic transmission in CeA. ► Chronic alcohol alters the effects of peptides on GABAergic transmission in CeA. ► Peptides that affect GABA in CeA also affect anxiety and excessive alcohol drinking.