Abnormalities in thalamic neurophysiology in schizophrenia: Could psychosis be a result of potassium channel dysfunction?

► Schizophrenia may involve failure in internal monitoring of self-initiated motor outputs. ► The thalamus may be involved in monitoring of efferent cortical motor outputs. ► The thalamus has been found to be markedly affected in schizophrenia. ► The thalamus displays burst firing mode prior to exploratory behaviors. ► Pharmacological agents that promote burst firing in the thalamus may have antipsychotic effects.