Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte

► Discover novel and high active FAS inhibitors isolated from pomegranate. ► The inhibitors obviously inhibited the lipid accumulation of 3T3-L1 pre-adipocytes. ► The inhibitory activity is rather than protein precipitation by tannin.