Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells

► Dimerumic acid (DMA) exerts Nrf2 activation in RINm5F pancreatic cells. ► DMA attenuated oxidative stress caused by methylglyoxal. ► DMA elevated insulin production and secretion from RINm5F cells. ► DMA exerts anti-diabetes by pancreas prevention.