Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2

► Label-free LC-MSMS comparison of vitreous proteins. ► 70 differentially regulated proteins detected in equine recurrent uveitis. ► 28 significantly enriched biological pathways. ► Wnt signalling changes in ERU. ► SFRP2 and Dkk3 link Wnt signalling changes to RMG cells